Evaluation of the relationship between microalbuminuria and 25-(OH) vitamin D levels in patients with type 2 diabetes mellitus

Uçak, Sema; Sevim, Ecem; Ersoy, Damla; Sivritepe, Rıdvan; Basat, Okcan; Atay, Sabri

doi:10.1080/13685538.2018.1479385

Cited by 20 publications

(23 citation statements)

References 21 publications

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“…A recent cross-sectional study of 351 Chinese inpatients with T2DM demonstrated that VDD was independently associated with DKD [21]. This was consistent with many previous studies which had linked albuminuria to low vitamin D levels [58][59][60][61][62]. Conversely, several studies reported discordant results [24,63,64].…”

Section: Discussionsupporting

confidence: 83%

Associations between vitamin D status and diabetic complications in Chinese population with type 2 diabetes mellitus: a cross-sectional study

Xiao

Wei

Xiong

et al. 2020

Preprint

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Background Vitamin D status has been linked to diabetes-related complications due to multiple extraskeletal effects. We aimed to investigate the association between vitamin D deficiency (VDD) and diabetic vascular complications, including diabetic retinopathy (DR), diabetic kidney disease (DKD), and diabetic foot ulcers (DFU).Methods A total of 4284 Chinese patients with type 2 diabetic mellitus (T2DM) were enrolled into the cross-sectional study. VDD was defined as serum 25-hydroxyvitamin D < 50 nmol/L. Demographic data, physical measurements, laboratory measurements, comorbidities, and related medications were collected and analyzed by VDD status. Poisson regression with robust variance estimation and binary logistic regression were performed to explore the relationship between VDD and diabetic complications.Results The prevalence of VDD, DR, DKD, DFU accounted to 71.7% (95% confidence intervals [CI]: 70.3%-73.0%), 28.5% (95% CI: 27.2%-29.9%), 28.2% (95% CI: 26.8%-29.5%) and 5.7% (95% CI: 5.1%-6.5%), respectively. The prevalence ratios (95% CI) for DR and DKD by VDD status, adjusted for demographics, physical measurements, laboratory measurements, related complications and comorbidities, and medications, were 1.093 (0.983–1.215) and 1.041 (0.937–1.156), respectively. The odds ratio (95% CI) for DFU by VDD status was 1.656 (1.159–2.367) in the final adjusted model. Meanwhile, the prevalence of VDD was significantly higher in patients with DFU compared with patients without DFU.Conclusions The present study firstly indicated that VDD was significantly associated with a higher prevalence of DFU among Chinese T2DM patients. The association between VDD status and DR or DKD was not significant when adjusting for all potential covariates. Vitamin D screening or supplementation may be beneficial to prevent diabetic complications and improve the prognosis of T2DM patients.

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Section: Discussionsupporting

confidence: 83%

Associations between vitamin D status and diabetic complications in Chinese population with type 2 diabetes mellitus: a cross-sectional study

Xiao

Wei

Xiong

et al. 2020

Preprint

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“…DR and DKD are common microvascular complications of diabetes ( 7 ). Many clinical studies have recognized VDD as the risk factor for DR ( 16 , 25 , 41 ) and DKD ( 17 , 42 ), whereas other epidemiological researches showed opposite results ( 21 , 22 , 43 ). In this study, we revealed that the correlation between VDD status and the prevalence of DR or DKD was not statistically significant after adjusting laboratory measurements, diabetic complications, related comorbidities, and medications besides the adjustment for demographics and physical measurements.…”

Section: Discussionmentioning

confidence: 99%

Association Between Vitamin D Status and Diabetic Complications in Patients With Type 2 Diabetes Mellitus: A Cross-Sectional Study in Hunan China

et al. 2020

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Background: Vitamin D status has been linked to diabetes-related complications due to multiple extraskeletal effects. We aimed to investigate the association between vitamin D deficiency (VDD) and diabetic vascular complications, including diabetic retinopathy (DR), diabetic kidney disease (DKD), and diabetic foot ulcers (DFU). Methods: A total of 4,284 Chinese patients with type 2 diabetic mellitus (T2DM) were enrolled into the cross-sectional study. VDD was defined as serum 25-hydroxyvitamin D <50 nmol/L. Demographic data, physical measurements, laboratory measurements, comorbidities, and related medications were collected and analyzed by VDD status. Poisson regression with robust variance estimation and binary logistic regression were performed to explore the relationship between VDD and diabetic complications.

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“…T2DM is more common in the elderly patients. In recent years, with the increase in the elderly population, the incidence rate of T2DM has shown an upward trend, and this disease has become a public health problem endangering people's health [9] . The pathogenesis of T2DM has not been fully elucidated and there is still a lack of means to cure T2DM, so the major treatment goal is to control blood glucose [10] .…”

Section: Abstract: Type 2 Diabetes Mellitus Insulin Secretion 25-hydroxyvitamin D3 Correlationmentioning

confidence: 99%

Correlation between Serum 25-Hydroxyvitamin D3 and Abnormal Insulin Secretion in Patients with Type 2 Diabetes Mellitus

Hou¹,

Hu²,

Chen³

et al. 2021

ijps

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Chen et al.: 25-Hydroxyvitamin D3 and type 2 diabetes mellitus To investigate the correlation between serum 25-hydroxyvitamin D3 and abnormal insulin secretion in patients with type 2 diabetes mellitus. Eight type 2 diabetes mellitus patients treated from January 2018 to November 2020 (observation group) and another 80 healthy volunteers receiving physical examination in the same period (control group) were included. Fasting venous blood sample was collected to detect serum 25-hydroxyvitamin D3, fasting blood glucose, glycosylated hemoglobin, fasting insulin, insulin resistance index and insulin secretion index. According to insulin secretion index, observation group was divided into normal and abnormal insulin secretion groups and their serum 25-hydroxyvitamin D3, fasting blood glucose, glycosylated hemoglobin, fasting insulin and insulin resistance index were compared. Based on serum 25-hydroxyvitamin D3 level, observation group was divided into serum 25-hydroxyvitamin D3 positive and negative groups and their fasting blood glucose, glycosylated hemoglobin, fasting insulin, insulin resistance index and insulin secretion index were compared. The correlations of serum 25-hydroxyvitamin D3 with fasting blood glucose, glycosylated hemoglobin, fasting insulin, insulin resistance index and insulin secretion index were analyzed. Observation group had lower serum 25-hydroxyvitamin D3 level and insulin secretion index and higher fasting blood glucose, glycosylated hemoglobin, fasting insulin and

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Evaluation of the relationship between microalbuminuria and 25-(OH) vitamin D levels in patients with type 2 diabetes mellitus

Abstract: This study found that the level of microalbuminuria was significantly higher in patients with 25-(OH) vitamin D deficiency compared to patients with 25-(OH) VD insufficiency.

Cited by 20 publications

References 21 publications

Associations between vitamin D status and diabetic complications in Chinese population with type 2 diabetes mellitus: a cross-sectional study

Associations between vitamin D status and diabetic complications in Chinese population with type 2 diabetes mellitus: a cross-sectional study

Association Between Vitamin D Status and Diabetic Complications in Patients With Type 2 Diabetes Mellitus: A Cross-Sectional Study in Hunan China

Correlation between Serum 25-Hydroxyvitamin D3 and Abnormal Insulin Secretion in Patients with Type 2 Diabetes Mellitus

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