Our study showed that psoriatic patients were more insulin resistant than healthy subjects and type II psoriatics were more susceptible than type I psoriatics to develop IGT. We suggest that beta-cell function and insulin sensitivity indices are useful methods for measuring insulin resistance in psoriatics. We propose that OGTT should be applied especially in type II psoriatics because of increased rate of IGT in this group.

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Hirsutism is characterized by excessive growth of terminal hair in a male pattern. Excessive hair growth in the absence of demonstrable androgen excess in ovulatory women is also referred to as idiopathic hirsutism (IH). IH is diagnosed in women who have hirsutism, normal ovulatory function and normal total or free testosterone levels. IH is a common cause of hirsutism. IH is not associated with any sign of virilization. Its cause is not understood completely. It has been proposed that women with IH have significantly increased cutaneous 5α-reductase activity. The presence or absence of such an association is not clear [1].Polycystic ovary syndrome (PCOS), another cause of hirsutism, is an insulin resistance related syndrome. Abstract. Hirsutism is characterized by excessive growth of terminal hair in a male pattern. Idiopathic hirsutism (IH) is a common cause of hirsutism. Since there are few data demonstrating IH is associated with insulin resistance, we tried to assess various insulin sensitivity indices in lean IH and compare with healthy subjects. A cross-sectional study was performed in 71 lean (BMI between 20-25 kg/m 2 ) women (17-39 years old), 31 with IH and 40 healthy individuals. Blood glucose, insulin, homeostasis model assessment of insulin resistance (HOMA-IR), hepatic insulin sensitivity (ISI HOMA ), Quicky index, reciprocal fasting insulin resistance index, fasting Belfiore index, and fasting glucose/insulin ratio (GIR) were estimated using a single fasting sample of glucose and insulin levels. Raynaud indices calculated using the mathematical estimation in a single fasting sample of insulin levels were determined and compared in two groups. Fasting insulin, Raynaud index, HOMA-IR and Fasting insulin resistance index (FIRI) results were higher in IH group than in controls (p<0.01, for all). Fasting Belfiore index, QUICKI index, ISI HOMA and FIRI -1 results were lower in IH group than in controls (p<0.01, for all). Our study showed that lean IH patients were more insulin resistant than healthy subjects. We propose that insulin sensitivity indices are useful methods for measuring insulin resistance in IH.Key words: Idiopathic hirsutism, Insulin resistance, Lean patients, Insulin sensitivity indices insulin resistance. There are few data demonstrating IH is associated with insulin resistance. Since the pathogenesis of IH is still unclear, we tried to assess various insulin sensitivity indices in lean IH and compare with healthy subjects. materials and methodsA cross-sectional study was performed in 71 lean (BMI between 20-25 kg/m 2 ) women (17-39 years old), 31 with IH and 40 healthy individuals. The protocol was approved by the hospital-based ethics committee. The protocol of the study was explained to all of the subjects. Informed consent was obtained before beginning the study.None of the control subjects had ovarian dysfunction, hirsutism, or hyperandrogenemia. The diagnosis of IH was based on the presence of hirsutism (modified Ferriman-Gallwey score, >8) [2], regular ovulatory menstrual cycles...