Evaluation of the relation between anemia and periodontitis by estimation of blood parameters: A cross-sectional study

Anumolu, Venkata Naga Sri Harsha; Adusumilli, Srikanth; Paidi, Kusumalatha

doi:10.4103/0972-124x.176392

Cited by 18 publications

(22 citation statements)

References 15 publications

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“…Similar results in MCV were seen in other studies [37][38][39]. A decrease in MCH value is seen in microcytic anemia caused due to iron deficiency, whereas an increase in MCH value is seen in macrocytic anemia caused by vitamin deficiency.…”

Section: Discussionsupporting

confidence: 77%

Estimation and Comparison of Erythrocyte and Hemoglobin Levels in Subjects with Healthy Periodontium and Chronic Periodontitis

Mann¹,

Subramanyam²,

Verma³

et al. 2017

Pesqui. bras. odontopediatria clín. integr.

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Objective: To compare and evaluate the relationship between anemia and periodontitis by estimation of peripheral blood between healthy patients and chronic periodontitis patients. Material and Methods: Of the total of 230 outpatients approached to participate in the study, 100 eligible patients were selected as per the selection criteria. After written consent, these patients were divided into two groups according to the clinical parameters as healthy and disease (chronic periodontitis) groups. Under aseptic conditions, venous blood samples were obtained by vein-puncture in the ante-cubital fossa without excessive venous stasis and the mean value of erythrocytes (EC), hemoglobin concentration (HGB), mean corpuscular volume (MCV) and mean corpuscular hemoglobin (MCH) were measured. Paired t-test was employed to find the significance of study parameters on continuous scale within the group analysis and unpaired t-test (two tailed, dependent) was used to find the significance of study parameters on continuous scale in the inter group analysis. Results: Generally, the healthy group reported higher levels of EC, HGB, MCV and MCH than the periodontitis group. The mean hemoglobin level was significantly higher (p-value<0.05) in healthy patients (12.66 ±1.41 gm/dl) whereas a slightly lower level of 11.32±1.85 gm/dl was observed in patients with chronic periodontitis. Similarly, the range of erythrocyte count of healthy patients was significantly higher (3.69-5.29 million/µl) than chronic periodontitis patients (3.33-5.97 million/µl). Whilst MCV was higher in healthy patients but non-significant, higher mean MCH of 27.75 ± 3.25 pg/cell was reported in healthy patients compared to mean of 25.73 ± 3.22 pg/cell in patients with chronic periodontitis. Conclusion: Significant hematological differences in EC, HGB, MCV and MCH between healthy periodontium and chronic periodontitis subjects were seen indicating mild anemia.

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Section: Discussionsupporting

confidence: 77%

Estimation and Comparison of Erythrocyte and Hemoglobin Levels in Subjects with Healthy Periodontium and Chronic Periodontitis

Mann¹,

Subramanyam²,

Verma³

et al. 2017

Pesqui. bras. odontopediatria clín. integr.

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“…Hb, RBC counts, hematocrit (HCT), mean corpuscular volume (MCV), mean corpuscular Hb (MCH), mean corpuscular Hb concentration (MCHC), and erythrocyte sedimentation rate (ESR) (Hutter et al, 2001;Gokhale et al, 2010;Naik et al, 2010;Prakash et al, 2012;Chakraborty et al, 2014;Kolte et al, 2014;Patel et al, 2014;Khan et al, 2015;Latha et al, 2015;Anumolu et al, 2016;Carvalho et al, 2016;Nibal et al, 2019).…”

Section: Characteristics Of Included Studiesmentioning

confidence: 99%

Decreased Hemoglobin Concentration and Iron Metabolism Disorder in Periodontitis: Systematic Review and Meta-Analysis

Zhang

Cao

et al. 2020

Front. Physiol.

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Background: Periodontitis is a chronic inflammatory disease with a possible infectious component. Anemia of inflammation (AI) occurring in various chronic diseases alters the hemoglobin (Hb) concentration and iron status. Currently, the association between periodontitis and AI is still controversial. The aim of this study was to assess the alterations of the level of hematological parameters and iron metabolism markers in patients with or without periodontitis. Methods: Electronic databases (MEDLINE, EMBASE, and Cochrane) were searched to identify publications about anemia and periodontitis. Subgroup analyses regarding gender, extent of periodontitis, and sample size were performed using STATA 12.1. Results: Sixteen studies were included in this meta-analysis. Pooled results showed a decrease in Hb [standardized mean difference (SMD) = −0.76, 95% CI = (−1.15, −0.37)], red blood cell [SMD = −0.69, 95% CI = (−1.09, −0.29)], hematocrit [SMD = −1.13, 95% CI = (−1.69, −0.57)], mean corpuscular volume [SMD = −0.16, 95% CI = (−0.32, −0.01)], and mean corpuscular Hb [SMD = −0.16, 95% CI = (−0.28, −0.04)], but upregulation in erythrocyte sedimentation rate [SMD = 0.63, 95% CI = (0.06, 1.19)]. In addition, patients with periodontitis had a higher level of hepcidin [SMD = 0.59, CI = (0.05, 1.12)] and decreased level of transferrin [SMD = −4.6, CI = (−13.1, −3.90)], with high heterogeneity. Conclusion: This meta-analysis indicates that periodontitis decreases Hb concentration and disturbs the balance of iron metabolism, which confirms strength of association between periodontitis and the development tendency of AI, especially for severe periodontitis. More unbiased cohort studies with larger sample sizes are still warranted to make a definitive judgment in the future.

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“…Furthermore, a study by Anumolu et al . () found reduced haemoglobin and erythrocyte counts and concluded that periodontitis encourages anaemia (Anumolu et al, ). Similar results were found in the previous investigation by this working group (Ziebolz et al, ).…”

Section: Discussionmentioning

confidence: 99%

High prevalence of periodontitis in blood donors and the possibility of questionnaire‐based screening – results of a cross‐sectional study

Schmalz

Hübscher

Angermann

et al. 2019

Transfusion Medicine

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Background:Periodontitis is an inflammatory disease of high prevalence and, thus, of potential relevance to the management of blood donation. Objectives:The aim of this cross-sectional study was to assess periodontal health and its associations to common blood parameters, as well as questionnaire-based periodontitis screening in blood donors. Methods:Generally healthy blood donors were recruited and underwent oral examination. Thereby, the decayed-, missingand filled-teeth index (DMF-T) and periodontal status, including periodontal probing depth and clinical attachment loss, were assessed. Based on periodontal status, periodontitis severity was classified into no/mild, moderate or severe. Six yes/no questions regarding periodontal complaints and history were asked. Furthermore, common blood parameters were analysed.Results: A total of 148 participants (mean age 53·33 years) were included. The DMF-T was 15·28 ± 6·44. Nearly three quarters of participants suffered from a periodontitis (moderate 59·5% and severe 14·8%, total periodontitis 74·3%). Periodontitis severity was associated with the history of dental visits caused by periodontal complaints (P < 0·01) and previous periodontal therapy (P < 0·01). Only procalcitonin was initially found to be associated with blood periodontitis severity (P = 0·02). This observation was not confirmed by post-hoc testing between subgroups (P i > 0·2). No further association between periodontitis severity and blood parameters was found (P i > 0·05). bacteria in peripheral blood are required in order to determine the relevance of this result for the safety of blood components.

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Evaluation of the relation between anemia and periodontitis by estimation of blood parameters: A cross-sectional study

Cited by 18 publications

References 15 publications

Estimation and Comparison of Erythrocyte and Hemoglobin Levels in Subjects with Healthy Periodontium and Chronic Periodontitis

Estimation and Comparison of Erythrocyte and Hemoglobin Levels in Subjects with Healthy Periodontium and Chronic Periodontitis

Decreased Hemoglobin Concentration and Iron Metabolism Disorder in Periodontitis: Systematic Review and Meta-Analysis

High prevalence of periodontitis in blood donors and the possibility of questionnaire‐based screening – results of a cross‐sectional study

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