Evaluation of the rat tissue reaction to experimental new resin cement and mineral trioxide aggregate cement

Yang, Won‐Kyung; Ko, Hyun Jung; Kim, Mi Ri

doi:10.5395/rde.2012.37.4.194

Cited by 8 publications

(7 citation statements)

References 25 publications

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“…For each slide, three microscopic fields were captured at magnification 400X. The inflammation was categorized by counting visible inflammatory cells on each field, according to a previous study [ 17 ] as follows: Score 0: represented non or few inflammatory cells Score 1: represented less than 25 cells Score 2: represented 25–125 cells Score 3: represented more than 125 cells …”

Section: Biocompatibility Evaluationmentioning

confidence: 99%

Marginal adaptation, solubility and biocompatibility of TheraCal LC compared with MTA-angelus and biodentine as a furcation perforation repair material

et al. 2020

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Background This study evaluated the marginal adaptation, solubility and biocompatibility of TheraCal LC compared with mineral trioxide aggregate (MTA-Angelus) and Biodentine when used as a furcation perforation repair material. Methods The marginal adaptation was assessed by scanning electronic microscope and presence of any gap between the dentin surface and filling material in each quadrant of the sample was analyzed at 1000 X magnification. The solubility was measured after one week by the ISO standard method. Biocompatibility was evaluated by the inflammatory response and radiography after one month and three months of repair of experimental furcation perforations in dog's teeth. Results There were significant differences in the marginal adaptation, solubility and biocompatibility of the tested materials (P < 0.05). TheraCal LC showed the highest frequency distribution of gap presence that was followed by the MTA-Angelus then Biodentine. The least soluble material after one week was TheraCal LC that was followed by the MTA-Angelus and Biodentine. After one month and three months, TheraCal LC showed the highest inflammatory response and highest frequency distribution of radiolucency that was followed by the Biodentine then MTA-Angelus. Conclusion Unlike Biodentine, TheraCal LC is incapable of alternating the MTA in furcation perforation repair due to its poor biocompatibility and poor marginal adaptation.

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Section: Biocompatibility Evaluationmentioning

confidence: 99%

Marginal adaptation, solubility and biocompatibility of TheraCal LC compared with MTA-angelus and biodentine as a furcation perforation repair material

et al. 2020

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“…Assessments of the biomineralization of different bioactive materials implanted in the subcutaneous tissue of a rat animal model using the von Kossa technique have been described previously [ 3 17 22 23 24 ]. This method is used for illustrating deposits of calcium or calcium salts.…”

Section: Discussionmentioning

confidence: 99%

Biomineralization of three calcium silicate-based cements after implantation in rat subcutaneous tissue

et al. 2021

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Objectives The aim of this study was to evaluate the dystrophic mineralization deposits from 3 calcium silicate-based cements (Micro-Mega mineral trioxide aggregate [MM-MTA], Biodentine [BD], and EndoSequence Root Repair Material [ESRRM] putty) over time after subcutaneous implantation into rats. Materials and Methods Forty-five silicon tubes containing the tested materials and 15 empty tubes (serving as a control group) were subcutaneously implanted into the backs of 15 Wistar rats. At 1, 4, and 8 weeks after implantation, the animals were euthanized ( n = 5 animals/group), and the silicon tubes were removed with the surrounding tissues. Histopathological tissue sections were stained with von Kossa stain to assess mineralization. Scanning electron microscopy and energy-dispersive X-ray spectroscopy (SEM/EDX) were also used to assess the chemical components of the surface precipitates deposited on the implant and the pattern of calcium and phosphorus distribution at the material-tissue interface. The calcium-to-phosphorus ratios were compared using the non-parametric Kruskal-Wallis test at a significance level of 5%. Results The von Kossa staining showed that both BD and ESRRM putty induced mineralization starting at week 1; this mineralization increased further until the end of the study. In contrast, MM-MTA induced dystrophic calcification later, from 4 weeks onward. SEM/EDX showed no statistically significant differences in the calcium- and phosphorus-rich areas among the 3 materials at any time point ( p > 0.05). Conclusions After subcutaneous implantation, biomineralization of the 3-calcium silicate-based cements started early and increased over time, and all 3 tested cements generated calcium- and phosphorus-containing surface precipitates.

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Section: Histopathological Evaluationmentioning

confidence: 99%

Adaptability, solubility and biocompatibility of TheraCal LC compared with MTA-Angelus and Biodentine as a furcation perforation repair material

Alazrag

Abu‐Seida

El-Batouty

et al. 2020

Preprint

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Background This study evaluated the adaptability, solubility and biocompatibility of TheraCal LC compared with mineral trioxide aggregate (MTA-Angelus) and Biodentine when used as a furcation perforation repair material.Methods The adaptability was assessed by scanning electronic microscope (SEM) and presence of any gap between the dentin surface and filing material in each quadrant of the sample was analyzed at 1000 X magnification. The solubility was measured after one week by the ISO standard method. Biocompatibility was assessed by the inflammatory response and radiography after one and three months of repair of experimental furcation perforations in dog's teeth.Results There were significant differences in the adaptability, solubility and biocompatibility of the tested materials (P <0.05). TheraCal LC showed the highest frequency distribution of gap presence that was followed by MTA-Angelus then Biodentine. The least soluble material after one week was TheraCal LC that was followed by MTA-Angelus and Biodentine. After one and three months, TheraCal LC showed the highest inflammatory response and highest frequency distribution of radiolucency that was followed by Biodentine then MTA-Angelus.Conclusion Unlike Biodentine, the TheraCal LC is incapable of alternating MTA in the furcation perforation repair due to its poor biocompatibility and poor marginal adaptation.

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Evaluation of the rat tissue reaction to experimental new resin cement and mineral trioxide aggregate cement

Cited by 8 publications

References 25 publications

Marginal adaptation, solubility and biocompatibility of TheraCal LC compared with MTA-angelus and biodentine as a furcation perforation repair material

Marginal adaptation, solubility and biocompatibility of TheraCal LC compared with MTA-angelus and biodentine as a furcation perforation repair material

Biomineralization of three calcium silicate-based cements after implantation in rat subcutaneous tissue

Adaptability, solubility and biocompatibility of TheraCal LC compared with MTA-Angelus and Biodentine as a furcation perforation repair material

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