Evaluation of the protective role of vitamin C in imidacloprid-induced hepatotoxicity in male Albino rats

Soujanya, S.; Lakshman, Mekala; Kumar, A Anand; Reddy, A Gopala

doi:10.4103/0976-9668.107262

Cited by 36 publications

(9 citation statements)

References 11 publications

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“…It is of interest to know that there was a significant reduction in the body weight of high dose exposed mice. The decrease in body weight is inconsistent with the previous studies [11] , [25] . Badgujar et al stated that the high exposure of imidacloprid resulted in decreased body weight and other pathological changes in BALB/c mice [26] .…”

Section: Discussioncontrasting

confidence: 99%

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Effect of imidacloprid on hepatotoxicity and nephrotoxicity in male albino mice

Arfat

Mahmood

Tahir³

et al. 2014

Toxicology Reports

101

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Imidacloprid (IC) is a systemic insecticide related to the tobacco toxin nicotine. IC is a toxic substance frequently used into combat insects, rodents and plants pests and other creatures that can pose problems for agriculture. We, therefore, planned this study to assess risk factors, biochemical and histological alterations associated with hepatotoxicity and nephrotoxicity. Forty-eight adult male albino mice were divided into four groups of 12 animals each. All the animals were given standard synthetic pellet diet. One group served as control, and the other three were served as experimental groups. Decrease in the body weight of the high dose group was observed at 15 mg/kg/day, and no mortality occurred during the treatment period. High dose of imidacloprid caused a significant elevation of serum clinical chemistry parameters, serum glutamic oxaloacetic transaminase (SGOT), serum glutamic pyruvate kinase (SGPT), alkaline phosphatase (ALP) and total bilirubin (TBIL). Histology of liver and kidney indicates hepatotoxicity and nephrotoxicity at a high dose of imidacloprid. Based on the morphological, biochemical and histopathological analysis, it is evident that imidacloprid induced toxicological effects at 15 mg/kg/day to mice. The results of the present study demonstrate that IC had significant effects on body weight, liver functions and kidney (p < 0.05) at a dose of 15 mg/kg body weight. IC treatment 5 and 10 mg/kg/day may be considered as no observed adverse effect level (NOAEL) for mice. It was concluded that IC can cause hepatotoxicity and nephrotoxicity at a dose much lower than the LD50 (131 mg/kg body weight) in mice.

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Section: Discussioncontrasting

confidence: 99%

“…These findings are in agreement with Kammon and colleagues [16] . The hepatotoxic effects noted here are in agreement with the findings of soujanya et al [25] .…”

Section: Discussionsupporting

confidence: 93%

Effect of imidacloprid on hepatotoxicity and nephrotoxicity in male albino mice

Arfat

Mahmood

Tahir³

et al. 2014

Toxicology Reports

101

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“…Atasayar et al [79] demonstrated that combined treatment of vitamin C and E with single acute dose (toxic dose) of cisplatin is able to normalize the histopathological alteration induced by cisplatin on kidney when compared with cisplatin alone treated group. The mechanisms by which ascorbic acid decreases the hepatotoxicity induced by cisplatin, is embodied in the fact that ascorbic acid might ameliorate the oxidative damage by decreasing LPO and altering antioxidant defense system [80] , [81] .…”

Section: Discussionmentioning

confidence: 99%

Biochemical changes associated with ascorbic acid–cisplatin combination therapeutic efficacy and protective effect on cisplatin-induced toxicity in tumor-bearing mice

Amenla

Prasad

2015

Toxicology Reports

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Cisplatin is one of the well-established anticancer drugs being used against a wide spectrum of cancers. However, full therapeutic efficacy of the drug is limited due to development of various toxicities in the host. This study examines the comparative therapeutic effectiveness and toxicities of cisplatin alone and in combination of dietary ascorbic acid (AA) in ascites Dalton's lymphoma-bearing mice. The findings show that the combination treatment of mice with ascorbic acid plus cisplatin has much better therapeutic efficacy against murine ascites Dalton's lymphoma (DL) in comparison to cisplatin alone and this may involve a decrease in reduced glutathione (GSH), catalase activity and increased lipid peroxidation (LPO) in Dalton's lymphoma tumor cells. At the same time, combination treatment indicates a protective role of ascorbic acid against cisplatin-induced tissue toxicities (side effects) in the hosts. Cisplatin-induced histopathological changes in liver, kidney and testes were decreased after combination treatment. The analysis of renal function test (RFT), liver function test (LFT) and sperm abnormalities also suggest an improvement in these parameters after combination treatment. Therefore, it may be concluded that the increased GSH level, catalase activity and decreased LPO in the tissues, i.e., liver, kidney and testes after combination treatment may be involved in its protective ability against cisplatin-induced tissue toxicities in the host.

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“…It was reported that, brain sections of rats treated with 80 mg/kg body weight revealed marked congestion in cerebellum, degeneration of Purkinje cells with loss of dendrites, vacuolation around neurons, and shrunken neurons on 14 th day of experiment. [ 26 ]…”

Section: Discussionmentioning

confidence: 99%

A three generation study with effect of imidacloprid in rats: Biochemical and histopathological investigation

Vohra

Khera

2015

Toxicol Int

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Objectives:This study was designed to evaluate the dose-dependent toxic effects of imidacloprid on the female ratsthat were treated through three generations (F0, F1, and F2). F2 female rats were sacrificed at the end of the experiment to see the long-term effect of imidacloprid.Materials and Methods:Rats were divided into three groups of 6 each. Group I served as control. Group II served as treated I and given 1/45th LD50 (10 mg/kg/day) of imidacloprid. Group III served as treated II and given 1/22th LD50 (20 mg/kg/day) of imidacloprid. After 60 days, oral administration of imidacloprid females were mated with normal males to get F1 and F2 generation. F2 generation female rats were sacrificed at the end of the experiment. Biochemical and a histopathological investigation was done for three groups of F2 generation and statistically analyzed by ANOVA.Results:Average feed intake of F2 female rats was significantly reduced (P < 0.01) at 20 mg/kg/day dose of imidacloprid. There was a significant increase in the activity of alanine aminotransferase, AKP, and glucose 6-phosphate dehydrogenase in Group III rats of F2 generation. There was a significant decrease in acetylcholine esterase activity in plasma and brain of both the imidacloprid treated groups. Tissue samples of liver, kidney, and brain of females of F2 generation showed histopathological condition.Conclusion:The results indicated that imidacloprid at a dose of 20 mg/kg bw/day exerts significant toxicological effects on biochemical and histological studies of F2 generation females as compare to 10 mg/kg bw/day.

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Evaluation of the protective role of vitamin C in imidacloprid-induced hepatotoxicity in male Albino rats

Cited by 36 publications

References 11 publications

Effect of imidacloprid on hepatotoxicity and nephrotoxicity in male albino mice

Effect of imidacloprid on hepatotoxicity and nephrotoxicity in male albino mice

Biochemical changes associated with ascorbic acid–cisplatin combination therapeutic efficacy and protective effect on cisplatin-induced toxicity in tumor-bearing mice

A three generation study with effect of imidacloprid in rats: Biochemical and histopathological investigation

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