Evaluation of the protective effects of<i>Ganoderma applanatum</i>against doxorubicin-induced toxicity in Dalton’s Lymphoma Ascites (DLA) bearing mice

Lalmuansangi, C; Zosangzuali, Mary; Lalremruati, Marina; Tochhawng, Lalchhandami; Siama, Zothan

doi:10.1080/01480545.2020.1812630

Cited by 5 publications

(2 citation statements)

References 52 publications

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“…Furthermore, the hepatic downregulation of the Nrf2/Keap‐1 pathway and, as a consequence, oxidative stress was correlated with alterations in the plasma biochemical parameters (triglycerides, HDL cholesterol, and the activities of LDH, ALT, and AST) in male mice fed a HCD. Regarding the LDH activity, different models of hepatic oxidative stress reported an increase in the enzyme activity, 34,47 an effect similar to that found in male mice exposed to the HCD. LDH enzyme is released from cells in response to cell damage, causing its baseline level to rise in the extracellular space and the bloodstream or other body fluids 23 .…”

Section: Discussionsupporting

confidence: 70%

Swimming training mitigates the sex‐specific hepatic disruption caused by a high‐calorie diet: The putative modulation of Nrf2/Keap‐1 pathway in male mice

Jardim

Müller

Nogueira

2021

Cell Biochemistry & Function

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This study investigated whether swimming protocol induces adaptations to sex‐specific oxidative stress and Nrf2/Keap‐1 pathway in the liver of mice fed a high‐calorie diet (HCD) during the early life period. Male and female Swiss mice were fed a standard or high‐calorie (enriched with 20% lard and 20% corn syrup) diets, and the trained mice were subjected to a swimming protocol (5 days/week) from 21st to 49th postnatal days. Males fed a HCD had more pronounced alterations in all parameters evaluated than females. Although there was no increase in body weight, the fat deposition was higher in male mice exposed to diet. The intake of HCD induced dyslipidemia mainly in males. In a sex‐dependent manner, the hepatic markers of oxidative damage, antioxidant defences, and a sensitive sulfhydryl protein were altered in mice fed a HCD. Swimming counteracted dyslipidemia, hepatic oxidative stress, and the Nrf2/Keap‐1 signalling downregulation, in a sex‐dependent manner, in mice exposed to a HCD. These findings demonstrate that a non‐pharmacological therapy, swimming protocol, contributed to adaptations of sex‐specific hepatic oxidative stress and Nrf2/Keap‐1 regulation in male mice fed a HCD.

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Section: Discussionsupporting

confidence: 70%

Swimming training mitigates the sex‐specific hepatic disruption caused by a high‐calorie diet: The putative modulation of Nrf2/Keap‐1 pathway in male mice

Jardim

Müller

Nogueira

2021

Cell Biochemistry & Function

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“…The preventive effects of numerous naturally occurring antioxidants against DOX-induced organ toxicity have been reported earlier. 60 Phenolic compounds such as oleuropein, sesamol, anthocyanins, curcumin, gingerol, and hydroxytyrosol have been used to reduce DOX-induced toxicity. 61 , 62 Similarly, flavonoids, a type of naturally occurring phenolic compounds, such as chrysin, naringenin, kaempferol, avicularin, isorhamnetin, chrysoeriol, hesperidin, apigenin, and baicalein, have been reported to possess protective effects against DOX-induced hepatoxicity, nephrotoxicity, and cardiotoxicity by increasing antioxidant enzymes.…”

Section: Resultsmentioning

confidence: 99%

Green Synthesis of Silver Nanoparticles Using Spilanthes acmella Leaf Extract and its Antioxidant-Mediated Ameliorative Activity against Doxorubicin-Induced Toxicity in Dalton’s Lymphoma Ascites (DLA)-Bearing Mice

et al. 2022

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Green synthesis of metal nanoparticles is a rapidly growing research area in the field of nanotechnology because of their biomedical applications. This study describes the synthesis of silver nanoparticles (AgNPs) using Spilanthes acmella leaf extract and its ameliorative effects against doxorubicin-induced toxicity. The formation of AgNPs was confirmed by a ultraviolet−visible (UV−vis) spectrum that revealed an absorption band at 430 nm. A shift in the absorption bands in Fourier-transform infrared spectroscopy (FT-IR) confirmed the bioactive molecules of S. acmella leaf extract that acted as a reducing and capping agent. The spherical shape of AgNPs was confirmed by scanning electron microscope (SEM) analysis, and the presence of elemental silver was indicated by energy dispersive X-ray spectroscopy (EDS) analysis. Xray diffraction (XRD) analysis revealed that the crystalline size of the synthesized AgNPs was 6.702 nm. Treatment of Dalton's lymphoma ascites (DLA) mice with 20 mg/kg of doxorubicin (DOX) significantly increased the activities of serum toxicity markers including aspartate aminotransferase (AST), alanine amino-transferase (ALT), and lactate dehydrogenase (LDH). However, compared to DOX alone treatment, the coadministration of DOX and AgNPs reduced AST, ALT, and LDH activities. DOX alone treatment reduced glutathione (GSH) contents and decreased the activities of glutathione-s-transferase (GST) and superoxide dismutase (SOD) in DLA mice. However, the administration of AgNPs to DOX-treated DLA mice increased GSH content and the activities of GST and SOD. Consistently, biosynthesized AgNPs were found to possess significantly higher free-radical scavenging activities when compared to the S. acmella leaf extract, as measured by ABTS, DPPH, and O 2•− assays. The biosynthesized AgNPs also showed significant inhibitory activities against erythrocyte hemolysis and lipid peroxidation in the liver homogenate.

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Preventive and therapeutic use of herbal compounds against doxorubicin induced hepatotoxicity: a comprehensive review

Mahmoudi

Arasteh

Elyasi

2023

Naunyn-Schmiedeberg's Arch Pharmacol

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Evaluation of the protective effects ofGanoderma applanatumagainst doxorubicin-induced toxicity in Dalton’s Lymphoma Ascites (DLA) bearing mice

Cited by 5 publications

References 52 publications

Swimming training mitigates the sex‐specific hepatic disruption caused by a high‐calorie diet: The putative modulation of Nrf2/Keap‐1 pathway in male mice

Swimming training mitigates the sex‐specific hepatic disruption caused by a high‐calorie diet: The putative modulation of Nrf2/Keap‐1 pathway in male mice

Green Synthesis of Silver Nanoparticles Using Spilanthes acmella Leaf Extract and its Antioxidant-Mediated Ameliorative Activity against Doxorubicin-Induced Toxicity in Dalton’s Lymphoma Ascites (DLA)-Bearing Mice

Preventive and therapeutic use of herbal compounds against doxorubicin induced hepatotoxicity: a comprehensive review

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