Evaluation of the protection of commercial live and inactivated NDV vaccines against Newcastle virus genotype VIId circulating in the field

Ellakany, Hany F.; El-Hamid, Hatem Abd; Nasef, Soad A.; Nasr, Sherif; Aziz, Mohamed Abdel; Gado, Ahmed R.; Zedan, Rasha

doi:10.21608/djvs.25271

Cited by 4 publications

(3 citation statements)

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“…MK984238). The intracerebral pathogenicity index of the isolated vNDV in chickens was 1.86 and the mean death time in the embryonated chicken eggs (ECEs) was 40 h [26]. The challenge virus was propagated and titrated in 10-day-old specific pathogen-free ECEs [27], and the required challenge dose was then prepared according to WOAH [28].…”

Section: Challenge Virusmentioning

confidence: 99%

Superior Efficacy of Apathogenic Genotype I (V4) over Lentogenic Genotype II (LaSota) Live Vaccines against Newcastle Disease Virus Genotype VII.1.1 in Pathogen-Associated Molecular Pattern-H9N2 Vaccinated Broiler Chickens

Elbestawy,

Ellakany,

Sedeik

et al. 2023

Vaccines

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A comparison of the efficacy of apathogenic genotype I (V4) and lentogenic genotype II (LaSota) strains of live Newcastle disease virus (NDV) vaccines was performed following vaccination with pathogen-associated molecular pattern (PAMP) H9N2 avian influenza vaccine and challenge with velogenic NDV genotype VII.1.1 (vNDV-VII.1.1). Eight groups (Gs) of day-old chicks were used (n = 25). Groups 1–4 received a single dose of PAMP-H9N2 subcutaneously, while Gs (1, 5) and (2, 6) received eye drops of V4 and LaSota, respectively, as two doses. All Gs, except for 4 and 8, were intramuscularly challenged with vNDV-VII.1.1 at 28 days of age. No signs were detected in Gs 1, 5, 4, and 8. The mortality rates were 0% in Gs 1, 4, 5, and 8; 40% in G2; 46.66% in G6; and 100% in Gs 3 and 7. Lesions were recorded as minimal in Gs 1 and 5, but mild to moderate in Gs 2 and 6. The lowest significant viral shedding was detected in Gs 1, 2, and 5. In conclusion, two successive vaccinations of broilers with a live V4 NDV vaccine provided higher protection against vNDV-VII.1.1 challenge than LaSota. PAMP-H9N2 with live NDV vaccines induced more protection than the live vaccine alone.

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Section: Challenge Virusmentioning

confidence: 99%

Superior Efficacy of Apathogenic Genotype I (V4) over Lentogenic Genotype II (LaSota) Live Vaccines against Newcastle Disease Virus Genotype VII.1.1 in Pathogen-Associated Molecular Pattern-H9N2 Vaccinated Broiler Chickens

Elbestawy,

Ellakany,

Sedeik

et al. 2023

Vaccines

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“…3 Positivity %: percentage of active virus shedder birds out of the tested samples. 4 N/A: not applicable. 5 Virus titers in the same column followed by different small letters are statistically different.…”

Section: Challenge Virus Sheddingmentioning

confidence: 99%

“…The clade VII.1.1 of the sub-genotype VII.1 of the class II NDV [1,2] is the most common clade causing several outbreaks in Africa, Asia, Europe, and South America despite extensive vaccinations using live and inactivated NDV vaccines with multiple regimes [3]. Most of the used vaccines belong to genotypes I and II NDV viruses that partially protect chickens from mortalities and clinical signs, but NDV shedding from infected birds to the environment persists [4].…”

Section: Introductionmentioning

confidence: 99%

Genotype VII.1.1-Based Newcastle Disease Virus Vaccines Afford Better Protection against Field Isolates in Commercial Broiler Chickens

Dewidar

Kilany²,

El-Sawah

et al. 2022

Animals

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This study evaluated the efficacy of live and inactivated conventional GII LaSota and recombinant GVII Newcastle disease vaccines in commercial broilers. The experimental groups (G2–G7) were vaccinated on day 7 and day 21 of age with live vaccines from the same vaccine type “GII LaSota, GVII vaccine (A), GVII vaccine (B)” via eye drop; however, G3, G5, and G7 received a single dose from inactivated counterpart vaccines subcutaneously on day 7 of age. Vaccine efficacy was evaluated based on elicited humoral immunity, clinical protection, and reduction in virus shedding after challenge with virulent GVII 1.1. strain. Results demonstrated that live and inactivated recombinant GVII vaccine based on VG/GA strain backbone elicited superior protection parameters (100% protection). Although the conventional GII LaSota live and inactivated vaccination regime protected 93.3% of vaccinated birds, the virus shedding continued until 10 DPC. The post-vaccination serological monitoring was consistent with protection results. The study concludes that conventional GII ND vaccines alone are probably insufficient due to the current epidemiology of the GVII 1.1 NDV strains. Our findings further support that protection induced by recombinant GVII 1.1. ND vaccines are superior. Interestingly, the efficacy of recombinant ND vaccines seemed to be influenced by the backbone virus since the VG/GA backbone-based vaccine provided better protection and reduced virus shedding.

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Immunogenicity and protective efficacy of an inactivated Newcastle disease virus vaccine encapsulated in poly-(lactic-co-glycolic acid) nanoparticles

Kumar¹,

Panickan²,

Bindu³

et al. 2023

Poultry Science

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Evaluation of the protection of commercial live and inactivated NDV vaccines against Newcastle virus genotype VIId circulating in the field

Cited by 4 publications

References 0 publications

Superior Efficacy of Apathogenic Genotype I (V4) over Lentogenic Genotype II (LaSota) Live Vaccines against Newcastle Disease Virus Genotype VII.1.1 in Pathogen-Associated Molecular Pattern-H9N2 Vaccinated Broiler Chickens

Superior Efficacy of Apathogenic Genotype I (V4) over Lentogenic Genotype II (LaSota) Live Vaccines against Newcastle Disease Virus Genotype VII.1.1 in Pathogen-Associated Molecular Pattern-H9N2 Vaccinated Broiler Chickens

Genotype VII.1.1-Based Newcastle Disease Virus Vaccines Afford Better Protection against Field Isolates in Commercial Broiler Chickens

Immunogenicity and protective efficacy of an inactivated Newcastle disease virus vaccine encapsulated in poly-(lactic-co-glycolic acid) nanoparticles

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