Evaluation of the Preventive Effect of Photobiomodulation on Orofacial Discomfort in Dental Procedures: A Randomized-Controlled, Crossover Study and Clinical Trial
“…e so-called target recognition is based on the more obvious the target color difference of the image, the more obvious the target, and the higher the recognition effect, efficiency, and accuracy; the detailed information of the image is mainly related to the contrast, edge, and texture of the image; the background color of the image is mainly affected by the color [17,18].…”
Section: Observers Of Subjective Evaluation Experimentsmentioning
With the continuous development of society and economy, diversified presentation and publicity of landscape are becoming more and more popular among the public, such as using color pictures to display multimedia publicity videos or APP, WeChat public accounts, and other new media. There are various ways of expression. Against the limitations of color image landscape, this article introduced the PFA algorithm, during the experiment of hand-painted landscape pictures, the effect of color hand-painted images is evaluated by using the coordination degree of natural target detection scene, and the corresponding image evaluation index values are obtained for effective analysis, and the prediction model is established. The simulation results show that the PFA algorithm is effective and can support the evaluation of the hand-painted effect of color landscape photos.
“…e so-called target recognition is based on the more obvious the target color difference of the image, the more obvious the target, and the higher the recognition effect, efficiency, and accuracy; the detailed information of the image is mainly related to the contrast, edge, and texture of the image; the background color of the image is mainly affected by the color [17,18].…”
Section: Observers Of Subjective Evaluation Experimentsmentioning
With the continuous development of society and economy, diversified presentation and publicity of landscape are becoming more and more popular among the public, such as using color pictures to display multimedia publicity videos or APP, WeChat public accounts, and other new media. There are various ways of expression. Against the limitations of color image landscape, this article introduced the PFA algorithm, during the experiment of hand-painted landscape pictures, the effect of color hand-painted images is evaluated by using the coordination degree of natural target detection scene, and the corresponding image evaluation index values are obtained for effective analysis, and the prediction model is established. The simulation results show that the PFA algorithm is effective and can support the evaluation of the hand-painted effect of color landscape photos.
“…The most signi cant limitation of the proposed protocol was the application time. Despite being extremely practical because it is a single application and can be performed on the day of the chemotherapy session, avoiding additional patient displacement (increased costs, discomfort, and dropout frequency), [5,8] the application lasts 15-20 min, which tires the medical professional and the patient [38,43]. And, although this was a single-center study with a single chemotherapy protocol used, this is the rst triple-blind randomized clinical trial that highlights the promising function of PBMT in preventing trans-chemotherapy taste loss.…”
Section: Discussionmentioning
confidence: 99%
“…Taste loss due to chemotherapy is strongly associated with in ammation and cytokines [42]. Because PBMT exhibits anti-in ammatory and antioxidant capacity [35,36,38,43], we consider the mechanisms involved in preventing taste loss during chemotherapy with AC observed in this study to be locally in ammatory in nature [8].…”
Purpose
To evaluate the effectiveness of photobiomodulation (PBMT) in preventing dysgeusia in breast cancer patients treated with doxorubicin-cyclophosphamide (AC).
Methods
This is a phase II, randomized, triple-blind, placebo-controlled clinical trial involving 112 breast cancer patients treated with AC. The patients were divided equally into two groups: a test group treated with 2 J red laser and 3 J infrared laser on 21 points that were symmetrically distributed on the tongue on day 0 of four cycles of AC, and an equal placebo group treated with simulated PBMT to blind the patient, evaluator, and statistician. The clinicopathological and sociodemographic data, results of the hematological tests, taste test, and subjective taste analysis, and the QoL, ECOG performance status, body mass index, and other side effects were recorded. The data were analyzed using ANOVA-RM/Bonferroni, Friedman/Dunn, and chi-square/Fisher's exact tests.
Results
PBMT patients showed less objective and subjective taste loss (p < 0.05). On the other hand, the placebo group showed a higher ECOG status (p = 0.037) and more significant weight loss (p < 0.001) after four cycles of AC. The QoL was significantly higherin the PBMT group (p < 0.05) at all assessment periods, and PBMT treatment also reduced the incidence of cachexia (p = 0.020), anorexia (p < 0.001), diarrhea (p = 0.040), oral mucositis (p = 0.020), and vomiting (p = 0.008).
Conclusion
PBMT reduced the taste loss and improved the overall health status and QoL of patients with breast cancer treated with AC.
Trial registration
: Brazilian Clinical Trials Registry (www.ensaiosclinicos.gov.br) approval numberRBR-9qnm34y, registered on 01/05/2021
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