Evaluation of the Prevalence of Human Papillomavirus and Epstein-Barr Virus in Esophageal Squamous Cell Carcinomas

Lyronis, Ioannis; Baritaki, Stavroula; Bizakis, Ioannis; Tsardi, M.; Spandidos, Demetrios Α.

doi:10.1177/172460080502000102

Cited by 20 publications

(8 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Specific anatomic locations included oral mucosa (n=7), esophagus (n=2), larynx (n=2), adenoids/tonsils (n=2), and parotids (n=1) (Aggelopoulou et al, 1999; Blioumi et al, 2014; Bouda et al, 2000; Gorgoulis et al, 1999; Kouvousi, et al, 2013; Lambropoulos et al, 1997; Laskaris et al, 2014; Lyronis I., 2005; Lyronis, et al, 2008; Mammas, et al 2012; Mammas, et al, 2006; Tsimplaki et al, 2014; Vageli, et al, 2007). Only 5 studies included asymptomatic patients (Blioumi, et al, 2014; Bouda, et al, 2000; Lambropoulos, et al, 1997; Lyronis I., 2005; Lyronis, et al, 2008). The remaining studies focused on testing patients with dysplasia, hyperplasia or cancer.…”

Section: Resultsmentioning

confidence: 99%

Human papillomavirus infection by anatomical site among Greek men and women: a systematic review

Tsikis

Hoefer²,

Charnot-Katsikas³

et al. 2016

European Journal of Cancer Prevention

View full text Add to dashboard Cite

Objectives We systematically reviewed the literature on anal, penile, cervical, and oropharyngeal HPV infection in Greece to provide a comprehensive overview of HPV prevalence and to explore the reporting of HPV in Greek men and women. Methods A total of 5 databases, including PubMed and Scopus, were searched up until January 1st, 2015 for studies looking at HPV prevalence, incidence, or risk factors by anatomical site. Results We identified 50 eligible studies for inclusion. The majority of them were cervical studies (n=26) followed by head and neck studies (n=13) with only two studies exclusively focusing on anal sites and two at penile sites. The remaining studies examined prevalence from multiple sites. Most studies looked at small, high-risk populations and HPV prevalence ranged from 2.5%–43.4% for cervical studies; 0%–91% for head and neck studies; 54.6%–78.4% for anal studies and 20.3%–66.7% for penile studies. Age, smoking, and number of sexual partners were commonly assessed risk factors. Conclusion There were significant gender and anatomic site disparities in the reporting of HPV prevalence. Given the relationship between HPV infection and the increasing incidence of anal cancer in men, more research is needed to reveal the prevalence of HPV at these sites in Greek men especially given reports of the declining health of the Greek population.

show abstract

Section: Resultsmentioning

confidence: 99%

Human papillomavirus infection by anatomical site among Greek men and women: a systematic review

Tsikis

Hoefer²,

Charnot-Katsikas³

et al. 2016

European Journal of Cancer Prevention

View full text Add to dashboard Cite

show abstract

“…Adjustment for confounding factors (11%) and statistical analysis of results (10%) both scored poorly. Only five studies [20], [21], [31], [32], [40] adjusted for confounders and odds ratios were calculated in only two studies [20], [21], contributing to the low scores allocated to these two areas of quality assessment. In addition, only 13 studies reported taking measures to ensure quality control or to prevent contamination of samples being tested for HPV [20], [21], [27], [30], [31], [33], [35], [36], [38], [39], [41], [43], [44].…”

Section: Resultsmentioning

confidence: 99%

“…There were 11 studies [20], [26], [29], [31], [33], [34], [39], [40], [42]–[44] for which ORs could be calculated using data provided in the papers. A meta-analysis of these studies alone (Figure 2) produced a pooled OR of 3.11 (95% CI 2.01 to 4.82) and an I 2 value of 33.77.…”

Section: Resultsmentioning

confidence: 99%

“…Nine studies analysed OSCC specimens from high incidence OSCC regions [20], [21], [30], [31], [33], [38], [39], [43], [44], while the remaining 12 studies recruited OSCC patients from low to medium risk OSCC populations [26]–[29], [32], [34]–[37], [40]–[42]. The HPV-OSCC association was positive and significant in both high (pooled OR 2.65, 95% CI 1.80 to 3.91) and low to medium (pooled OR 4.65, 95% CI 2.47 to 8.76) incidence regions as demonstrated in Figure 6.…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

The Aetiological Role of Human Papillomavirus in Oesophageal Squamous Cell Carcinoma: A Meta-Analysis

et al. 2013

View full text Add to dashboard Cite

BackgroundThe aetiological role of human papillomavirus (HPV) in oesophageal squamous cell carcinoma (OSCC) has been widely researched for more than three decades, with conflicting findings. In the absence of a large, adequately powered single case-control study, a meta-analysis of all available case-control studies is the most rigorous way of identifying any potential association between HPV and OSCC. We present the first global meta-analysis of case-control studies investigating the role of HPV in OSCC.MethodsCase-control studies investigating OSCC tissue for presence of HPV DNA were identified. 21 case-control studies analyzing a total of 1223 cases and 1415 controls, met our inclusion criteria. HPV detection rates were tabulated for each study and all studies were assessed for quality. The random effects method was used to pool the odds ratios (OR).ResultsFrom all OSCC specimens included in this meta-analysis, 35% (426/1223) were positive for HPV DNA. The pooled OR for an HPV-OSCC association was 3.04 (95% CI 2.20 to 4.20). Meta-regression analysis did not find a significant association between OR and any of the quality domains. Influence analysis was non-significant for the effect of individual studies on the pooled estimate. Studies conducted in countries with low to medium OSCC incidence showed a stronger relationship (OR 4.65, 95% CI 2.47 to 8.76) than regions of high OSCC incidence (OR 2.65, 95% CI 1.80 to 3.91).ConclusionsUncertainty around the aetiological role of HPV in OSCC is due largely to the small number and scale of appropriately designed studies. Our meta-analysis of these studies suggests that HPV increases the risk of OSCC three-fold. This study provides the strongest evidence to date of an HPV-OSCC association. The importance of these findings is that prophylactic vaccination could be of public health benefit in prevention of OSCC in countries with high OSCC incidence.

show abstract

“…The relation between human papillomavirus (HPV) and EC still remains controversial, 19–24 owing to the variation in environmental and geographic factors, genetic susceptibility and sensitivity of techniques used in the detection of the virus. Although the evidence is not conclusive, it is likely that HPV plays a role in the pathogenesis of ESCC in high‐incidence areas 25–27 .…”

Section: Discussionmentioning

confidence: 99%

Characterization of one newly established esophageal cancer cell line CSEC from a high-incidence area in China

Shu

Tian

et al. 2008

Dis Esophagus

View full text Add to dashboard Cite

The Chaoshan littoral is located in a high-incidence area of esophageal cancer in the south of China. In this study, a new esophageal cancer cell line CSEC was established from a 47-year-old female Chinese patient in this district. The biological characters of the cultured cells were investigated, including morphology, ultrastructure, growth kinetic features, tumorigenicity, expression of tumor-associated antigen and cytogenetic features. CSEC cell line grew continuously with a doubling time of 39.5 h and had been passaged over 80 times. The CSEC cells possessed features of squamous epithelial cells with cytokeratin indicated by immunohistochemical staining and tonofilaments and desmosomes revealed by electron microscopy. Tumorigenicity to severe combined immunodeficient mice was confirmed and the tumors developed revealed well-differentiated squamous cell carcinoma, similar to the origin tumor from which the cell line derived. The cytogenetic analysis demonstrated hypertetraploid karyotypes. Chromosome structure aberrations were common and complicated. Immunohistochemical staining showed that CSEC cells were infected with HPV and over-expressed p53. In summary, the CSEC cell line is a well-differentiated esophageal squamous cell carcinoma cell line from a high-incidence area in southern China. It may provide a useful model for the pathogenesis and therapeutic research of esophageal squamous cell carcinoma.

show abstract

Evaluation of the Prevalence of Human Papillomavirus and Epstein-Barr Virus in Esophageal Squamous Cell Carcinomas

Cited by 20 publications

References 22 publications

Human papillomavirus infection by anatomical site among Greek men and women: a systematic review

Human papillomavirus infection by anatomical site among Greek men and women: a systematic review

The Aetiological Role of Human Papillomavirus in Oesophageal Squamous Cell Carcinoma: A Meta-Analysis

Characterization of one newly established esophageal cancer cell line CSEC from a high-incidence area in China

Contact Info

Product

Resources

About