Evaluation of the presence of Helicobacter species in the biliary system of Turkish patients with cholelithiasis

Bostanoğlu, Ebru; Karahan, Zeynep Ceren; Bostanoğlu, Akın; Savaş, Berna; Erden, Esra; Kıyan, Mehmet

doi:10.4318/tjg.2010.0130

Cited by 10 publications

(11 citation statements)

References 21 publications

(17 reference statements)

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“…Firstly, most studies on this issue were observational reports without control groups. When it comes to case-control studies, many of them have involved either small sample size of lithiasis patients, or even smaller members of controls [10], [11]. Insufficient sample size may not have enough power to distinguish the differences between the two groups.…”

Section: Introductionmentioning

confidence: 99%

Are Helicobacter Pylori and Other Helicobacter Species Infection Associated with Human Biliary Lithiasis? A Meta-Analysis

et al. 2011

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BackgroundSince the isolation of Helicobacter species in biliary system, a hypothetical question was raised about the role of these agents in the development of cholelithiasis. This meta-analysis is to explore the association between the Helicobacter infection and biliary lithiasis.Methodology/Principal FindingsA systematic literature search was performed to identify all eligible articles. Meta-analysis which was carried out using odds ratio and random effect model, 95% confidence intervals for odds ratio was calculated. Quantitative assessment of heterogeneity was explored by chi-square test with significance set at P value 0.10 and was measured using I 2 statistic. Eighteen studies published between 1998 and 2011 were finally eligible for meta-analysis. H. Pylori, H. Bilis, H. Hepaticus, H. Pullorum and H. Ganmani were studied. With heterogeneity (I2 = 69.5%, P<0.0001), significantly higher pooled infection rates of H. Pylori (OR: 2.59, 35.82% versus 26.75%, P = 0.01) and H. Hepaticus (OR: 3.13, 31.30% versus 12.12%, P = 0.02) were observed in lithiasis group. Higher prevalence of H. Pylori in cholelithiasis patients were reported by studies from East Asia, South Asia and South America. Evidences supporting the higher presence of H. Pylori in cholelithiasis patients could be found by PCR for detecting 16s rRNA in bile, 26kDa protein gene in biliary tissue and immunohistochemistry. Using multiple detection tests could increase the detection rate of H. Pylori.Conclusions/SignificancesOur meta-analysis suggests a trend of higher presence of H. Pylori in cholelithiasis patients than control group and this trend was significant in the regions with higher prevalence of this agent. Evidences supporting the association between Helicobacter and cholelithiasis could be found by using different tests but the gold standard for the identification of these bacteria in biliary system has yet to be established. Considering obvious heterogeneity, a large multi-center study will facilitate us to further clarify the association between the Helicobacter infection and cholelithiasis.

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Section: Introductionmentioning

confidence: 99%

Are Helicobacter Pylori and Other Helicobacter Species Infection Associated with Human Biliary Lithiasis? A Meta-Analysis

et al. 2011

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“…Most studies suggest that women are more prone to suffer from gallstone formation and that the incidence of gallstones is increased in pregnant women and in patients taking hormone supplements (1,21). Studies on patients with liver cirrhosis also found that the prevalence is higher in females than in males (2).…”

Section: Shi Et Al Gallstones Subjected To Liver Transplantationmentioning

confidence: 99%

Gallstones in liver transplant recipients: A single-center study in China

Shi¹,

Shen²,

Teng³

et al. 2015

Turk J Gastroenterol

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Background/Aims: Liver transplant recipients include patients who present with almost all kinds of end-stage liver disease. Studying the relationship between gallstones and end-stage liver disease among liver transplant recipients is becoming important. Materials and Methods: Multiple logistic regression analysis was applied to assess 1640 liver transplant recipients. Multiple factors were involved in the analysis, including age, sex, total bilirubin and total cholesterol levels, Child score, hepatitis B virus (HBV) infection, hepatitis C virus (HCV) infection, alcoholic cirrhosis, and hepatocellular carcinoma (HCC). Results: Age and Child score are independent risk factors for the development of gallstone disease (GD). The average age of the recipients in the GD group was 49.22±9.96 years, which was significantly higher than that in the GD-free group (48.23±9.79 years). The Child score of the recipients in the GD group was 9.21±2.47, which was significantly lower than that of the recipients in the GD-free group, which was 8.79±2.48 (t=3.23, p<0.001). We also found that hepatitis B is an influential factor in GD. Conclusion: The prevalence of gallstones among liver transplant recipients is related to the Child score and patient age. The prevalence of GD is lower in patients with HCC and in those who are HBV positive and is relatively higher in HCV-positive patients and in those with alcoholic cirrhosis, although no significant differences were found.

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“…On the other hand, the results of other studies have shown that there is not any significant relationship between H. pylori infection and chronic cholecystitis, or stone formation in the gallbladder [24][25][26]. Helaly and colleagues showed that H. pylori is present in almost 40.9% of samples in patients with chronic calcular cholecystitis [23].…”

mentioning

confidence: 99%

“…In a study by Arismendi -Morillo and colleagues using Giemsa and hematoxylin -eosin staining to detect the bacteria, it was shown that only 6% of the chronic cholecystitis cases were positive for H. pylori [24]. In a similar study, Bostanoglu and colleagues showed that no samples were positive for Helicobacter species among the 47 gallstone associated cholecystitis cases [25]. Also, study of Yucebilgili and colleagues showed that despite 22% of samples were positive for bacteria, no significant association was found between H. pylori infection and cholelithiasis [27].…”

mentioning

confidence: 99%

The Relationship Between Cholecystitis and Presence of Helicobacter pylori in the Gallbladder

Motie

Rezapanah

Abbasi

et al. 2017

Zahedan J Res Med Sci

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Background: As there is an established relationship between Helicobacter pylori infection and gastric and duodenal ulcers, there might also be a relationship between this infection and other pathologies of gastrointestinal system. Objectives: Thus in this study we decided to investigate the relationship between H. pylori infection and cholecystitis. Methods: In this case-control study, patients were divided into two groups: case group with cholecystitis or cholelithiasis and controls with normal gallbladder. In both groups, after removal of the gallbladder, the samples were sent to the pathology laboratory for further evaluation. The presence of H. pylori gene in gallbladder tissue was determined by PCR (Polymerase chain reaction), and the results were compared between the groups.

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Evaluation of the presence of Helicobacter species in the biliary system of Turkish patients with cholelithiasis

Cited by 10 publications

References 21 publications

Are Helicobacter Pylori and Other Helicobacter Species Infection Associated with Human Biliary Lithiasis? A Meta-Analysis

Are Helicobacter Pylori and Other Helicobacter Species Infection Associated with Human Biliary Lithiasis? A Meta-Analysis

Gallstones in liver transplant recipients: A single-center study in China

The Relationship Between Cholecystitis and Presence of Helicobacter pylori in the Gallbladder

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