Evaluation of the pre-ejection period as an estimate of myocardial contractility in dogs

Talley, Robert C.; Meyer, Jerry F.; McNay, J. L.

doi:10.1016/0002-9149(71)90435-8

Cited by 163 publications

(62 citation statements)

References 22 publications

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“…The shortening of PEP and PEPI is interpreted as an increase in contractility. Talley, Meyer & McNay (1971) have shown that PEPI is a reliable index for estimation of changes in contractility when only small changes in preload and afterload are present as in this study. A shortening in PEPI was seen in all but two cases after dobutamine 5 gg kg-' min-' as anticipated.…”

Section: Discussionsupporting

confidence: 62%

The use of dobutamine in myocardial infarction for reversal of the cardiodepressive effect of metoprolol.

Waagstein¹,

Málek²,

Hjalmarson³

1978

Brit J Clinical Pharma

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1 Ten patients with acute myocardial infarction were infused dobutamine in increasing doses up to 15 microgram kg‐1 min‐1. 2 Metoprolol (total dose 15 mg) was then given intravenously to nine of these patients and the beta‐adrenoceptor against effects produced by dobutamine were effectively reversed. 3 Nine patients with acute myocardial infarction pretreated with metoprolol (15 mg) were infused dobutamine 15 microgram kg‐1 min‐1 for 10 min. This resulted in effective reversal of the beta‐adrenoceptor antagonist effects induced by metoprolol, without the occurrence of serious arrhythmias or other unwanted effects. 4 Dobutamine may be valuable in counteracting any undesirable cardiodepressive effects of beta‐adrenergic receptor blocking drugs (especially the cardioselective agents) in patients with acute myocardial infarction.

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Section: Discussionsupporting

confidence: 62%

The use of dobutamine in myocardial infarction for reversal of the cardiodepressive effect of metoprolol.

Waagstein¹,

Málek²,

Hjalmarson³

1978

Brit J Clinical Pharma

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“…Systolic time intervals have been widely used as a noninvasive measure of left ventricular performance (22,38). Excellent direct correlation between the PEP and the first derivative of left ventricular pressure rise (dp/dt) has been shown experimentally (39)(40)(41). However, PEP is limited as a measure of left ventricular function, particularly because it is also affected by both the left ventricular end diastolic and systemic arterial pressure (42).…”

Section: Discussionmentioning

confidence: 99%

Autonomic Mechanisms in Hemodynamic Responses to Isometric Exercise

Martin¹,

Shaver²,

Leon³

et al. 1974

J. Clin. Invest.

202

113

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A B S T R A C T Selective autonomic blockade with intravenous propranolol, practolol, atropine, and combined atropine-propranolol was utilized to elucidate the role of the autonomic nervous system in the hemodynamic responses in young adult male volunteers to handgrip sustained at 30% of maximal voluntary contraction for 3 min. The initial 30 s of the tachycardia response was found to be mediated by withdrawal of vagal dominance, as evidenced by blockade of this response by prior atropinization. The mid and late portion of the heart rate response curve was demonstrated to be sympathetic in origin, since it was unaffected by atropine, but was suppressed by combined atropine-propranolol blockade. Sympathetic stimulation appears to be a secondary mechanism for increasing the heart rate, however, as it becomes operative only after the first mechanism of vagal withdrawal has been utilized. This was confirmed by the finding that beta adrenergic receptor blockade alone had little effect on the heart rate response curve.The pressor response to handgrip was accompanied by increased cardiac output and no change in calculated systemic vascular resistance. After propranolol, handgrip resulted in increased peripheral resistance and an equivalent rise in arterial pressure, but no increase in cardiac output. It was concluded that the increase in resistance was the result of sympathetically induced vasoconstriction. This response was shown to be independent of peripheral beta adrenergic receptor blockade by the use of practolol, a cardio-selective beta adrenergic receptor-blocking drug which caused identical hemoPortions of this study were presented previously in abstract form.

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“…T alley et al [19] also demonstrated abnormal shortening of PEP in dogs when the LVEDP was increased by acute volume overloading. These in vestigators also found that acute elevation of LVEDP resulted in sig nificant increase in left ventricular dp/dt.…”

Section: Discussionmentioning

confidence: 93%

Comparison of the Invasive and Noninvasive Measurements in Coronary Artery Disease

Ishikawa

et al. 1974

Cardiology

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A comparison was made between invasive and noninvasive indices of left ventricular function in patients with and without coronary artery disease. In patients with three vessel disease, dp/dt max was lower and Δ PEP longer than in normal individuals. In patients with left ventricular dyskinesia, dp/dt max and cardiac index were significantly lower and ΔPEP was longer than in patients with normal left ventriculograms. Both dp/dt max and noninvasive indices Δ PEP and PEP/LVET) were found to be sensitive indices of left ventricular function in the recognition of patients with left ventricular dyskinesia and severe coronary artery disease.

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Evaluation of the pre-ejection period as an estimate of myocardial contractility in dogs

Cited by 163 publications

References 22 publications

The use of dobutamine in myocardial infarction for reversal of the cardiodepressive effect of metoprolol.

The use of dobutamine in myocardial infarction for reversal of the cardiodepressive effect of metoprolol.

Autonomic Mechanisms in Hemodynamic Responses to Isometric Exercise

Comparison of the Invasive and Noninvasive Measurements in Coronary Artery Disease

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