Evaluation of the Potential of Marine Algae Extracts as a Source of Functional Ingredients Using Zebrafish as Animal Model for Aquaculture

Monteiro, Mariana P.; Lavrador, Ana S.; Santos, Rafaela; Rangel, Fábio; Iglesias, Paula; Tárraga, M; Couto, Ana; Serra, Cláudia R.; Tafalla, Carolina; Costa, Elisabete da; Domingues, M. Rosário; Oliva‐Teles, Aires; Carvalho, António Paulo; Enes, Paula; Díaz‐Rosales, Patricia

doi:10.1007/s10126-021-10044-5

Cited by 15 publications

(8 citation statements)

References 94 publications

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“…11 Chlorella, as a common health care product, 12,13 also has anti-oxidation and anti-aging properties. It is oen used as a dietary supplement in aquaculture 14 since the addition of chlorella to sh diets improves enteritis caused by sh meal diets and improves sh performance against pathogens. 15 At present, there are occasional reports about using chlorella to make bio-based CDs, which are oen used for detection metal ions.…”

Section: Introductionmentioning

confidence: 99%

Green synthesis of chlorella-derived carbon dots and their fluorescence imaging in zebrafish

Wang,

Gu,

Dong

et al. 2024

RSC Adv.

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Section: Introductionmentioning

confidence: 99%

Green synthesis of chlorella-derived carbon dots and their fluorescence imaging in zebrafish

Wang,

Gu,

Dong

et al. 2024

RSC Adv.

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“…Furthermore, phenolic compounds, including terpenoids, anthocyanins and phenolic rich extracts, have been reported to inhibit the nuclear translocation of nuclear factor-κB, which is involved in the activation of several pro-inflammatory genes, but further investigations are needed to unveil the exact mechanisms of action [57,58]. Thus, by preventing an excessive pro-inflammatory response, which in turn, leads to increased susceptibility to secondary infections [59], dietary supplementation of phenolicrich extracts (FV and NG) could be used as a valuable prophylactic immunotherapy strategy in aquaculture facilities, as suggested by [60].…”

Section: Discussionmentioning

confidence: 99%

Functional Feeds to Tackle Meagre (Argyrosomus regius) Stress: Physiological Responses under Acute Stressful Handling Conditions

et al. 2021

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Marine algae are recognised sources of bioactive compounds that have attracted great interest as nutritional supplements for aquaculture fish. Intensive rearing conditions often expose fish to husbandry-related stressors, rendering fish more susceptible to disease and reducing production yields. The present work evaluated the potential of two marine algae extracts (Fucus vesiculosus and Nannochloropsis gaditana) as nutritional supplements to mitigate stress effects in meagre (Argyrosomus regius) exposed to an acute handling stress (AS). A plant-based diet was used as a control, and three other diets were prepared, which were similar to the control diet but supplemented with 1% of each algal extract or a combination of the two extracts (0.5% each). The effects of supplemented diets on stress biomarkers, antioxidant enzyme activities, and immune response were analysed in fish exposed to AS after 4 weeks of feeding. Supplemented diets did not affect growth performance but the inclusion of F. vesiculosus promoted higher feed efficiency, as compared to the control group. Dietary algal extracts supplementation reduced plasma glucose levels, increased white blood cell counts, and reduced the expression of pro-inflammatory genes when compared with the control. N. gaditana supplementation led to a reduction in hepatic antioxidant enzyme activity and glutathione levels, while F. vesiculosus supplementation increased muscle glutathione reductase activity and reduced lipid peroxidation. These findings support the potential of algal extracts as nutraceuticals in aquafeeds to enhance the ability of fish to cope with husbandry-related stressful conditions and ultimately improve fish health and welfare.

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“…PUFAs and pigments) of microalga diets that were greater than in DC tested in vitro (data not shown). Therefore, the antimicrobial activity of microalgae-enriched diets must be tested both in vitro and in vivo (Monteiro et al 2021). The possibility of the diets enriched with microalga has an antibacterial activity due to no-polar molecules, which is proven to be efficient against gramnegative bacteria (Shannon & Abu-Ghannam 2016).…”

Section: Discussionmentioning

confidence: 99%

Dietary supplementation effect of three microalgae on Penaeus vannamei growth, biochemical composition, and resistance to Vibrio parahaemolyticus (AHPND)

González-Meza

Herrera-Castro

Casillas-Hernández

et al. 2022

Lat. Am. J. Aquat. Res.

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Microalgae are a promising solution in shrimp farming overexploitation. This study assessed the efficacy of microalgae as a food additive for Penaeus vannamei growth and their effect on immune system stimulation against Vibrio parahaemolyticus. Three diets were formulated with 0, 1, and 3% (DC, D1, and D3, respectively) of a mixture of three different microalga species, Tetraselmis suecica, Dunaliella salina, and Chaetoceros muelleri, and growth, survival, and post-harvest quality in shrimp culture were evaluated. Two bioassays were performed: a 60-day feeding trial and an immersion infection bioassay against V. parahaemolyticus. D1 was the best treatment and significantly different to DC (P ≤ 0.05), achieving a food conversion factor of 1.24 ± 0.11 and 1.85 ± 0.38; specific growth rate 1.58 ± 0.03% d-1 and 1.35 ± 0.11% d-1; and weight gain of 5.68 ± 0.32 g and 4.79 ± 0.33 g, respectively. Protein content in shrimp muscle was positively increased by microalgae inclusion, achieving 20.8 ± 0.2% (D1) to 21.7 ± 0.3% (D3), 19.2 ± 0.1% (DC). In the infection bioassay, D1 and D3 reached a 100% survival rate, and histological damage in the hepatopancreas was not observed, suggesting immune system stimulation. These results indicated that microalgae added to food are an excellent source of proteins, carbohydrates, lipids, and promoters of antimicrobial activity that allowed additional protection against mortality caused by V. parahaemolyticus.

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Evaluation of the Potential of Marine Algae Extracts as a Source of Functional Ingredients Using Zebrafish as Animal Model for Aquaculture

Cited by 15 publications

References 94 publications

Green synthesis of chlorella-derived carbon dots and their fluorescence imaging in zebrafish

Green synthesis of chlorella-derived carbon dots and their fluorescence imaging in zebrafish

Functional Feeds to Tackle Meagre (Argyrosomus regius) Stress: Physiological Responses under Acute Stressful Handling Conditions

Dietary supplementation effect of three microalgae on Penaeus vannamei growth, biochemical composition, and resistance to Vibrio parahaemolyticus (AHPND)

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