Evaluation of the Potential Living Kidney Donor

Pham, Phuong‐Chi T.; Wilkinson, Alan H.; Pham, Phuong‐Thu T.

doi:10.1053/j.ajkd.2007.08.022

Cited by 29 publications

(46 citation statements)

References 10 publications

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“…There are international consensus reports on the standard definition for the evaluation of LKD (5)(6)(7)(8). Medical causes such as obesity, hypertension and DM are the significant exclusion reasons for living kidney donation (9-13).…”

Section: Discussionmentioning

confidence: 99%

“…Evaluation and exclusion reasons of living donor candidates might differ among centers, although there are some international consensus reports on the standard definition for the evaluation of living donor candidates (5)(6)(7)(8). Obesity, hypertension, low estimated glomerular filtration rate (GFR) are the major contraindications for donor exclusion in the literature of several countries (9-13).…”

Section: Introductionmentioning

confidence: 99%

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Exclusion Reasons of Living Kidney Donor Candidates: A Single-Center Experience

Oruç¹,

Tandogan²,

Karadayı³

et al. 2014

Turk Neph Dial Transpl

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OBJECTIVE: Due to severe organ shortage, living kidney donors are important choices for transplantation. In Muslim countries, such as Turkey, living kidney donors are the main source of donor pool. In the literature, reasons for living donor exclusion are reported from several countries. However, there is no published study that focused on exclusion reasons of donor candidates in Turkey where living kidney transplantation rate is 73.4%. The goal of this retrospective study was to examine the exclusion reasons for donation among living kidney donor candidates at a single center in Turkey. MATErIAl and METHOds:A total 538 adults were evaluated as a living kidney donor candidate between December 1988 and January 2012. Evaluation outcome, exclusion reasons and demographic data were examined from electronic file system and immunology laboratory records. rEsulTs:In this period 451 kidney transplantations (38.6% cadaveric, 61.4% living donor) was performed. Overall 261 (48.5%) donor candidates who underwent evaluation could not donate. We were able to find the precise cause of exclusion of 86 donors (33%). Among excluded donor candidates the most common exclusion reason was medical causes (64%) such as diabetes mellitus, low glomerular filtration rate and hypertension.COnClusIOn: Our study suggests that medical causes are significant exclusion reasons for living kidney donation at our center. KEy wOrds: Kidney transplantation, Living kidney donor, Donor evaluation, Exclusion reasonÖz AMAÇ: Organ bağışının istenilen düzeyde olmaması nedeni ile canlı böbrek nakli verici adayları, böbrek nakli için önemli kaynak oluşturmaktadır. Türkiye gibi Müslüman ülkelerde bu durum daha da belirgindir. Literatürde çeşitli ülkelerden böbrek nakli için canlı verici adaylarının elenme nedenlerini bildiren çalışmalar mevcuttur. Canlı böbrek nakli oranının %73,4 olduğu ülkemizden ise verici adaylarının elenme nedenlerine yönelik bir çalışma bulunmamaktadır. Çalışmamızın amacı, retrospektif olarak canlı böbrek nakli verici adaylarının elenme nedenlerini değerlendirmektir. GErEÇ ve yÖnTEMlEr:Çalışmaya Aralık 1988 ve Ocak 2012 tarihleri arasında merkezimize böbrek nakli verici adayı olarak başvurmuş 538 kişi dahil edilmiştir. Elektronik dosyaların ve immünoloji laboratuvar kayıtlarının taranması ile adaylık değerlendirme sonuçları, elenme nedenleri ve demografik bilgileri değerlendirilmiştir.BulGulAr: Çalışma süresince merkezimizde 451 böbrek nakli (%38,6 kadaverik, %61,4 canlı) gerçekleştirilmiştir. Adaylardan 261 (%48,5) kişi verici olamamıştır. Seksen altı (%33) adayın kesin elenme nedenine ulaşabilmiştir. Diyabetes mellitus, düşük glomerüler filtrasyon hızı ve hipertansiyon gibi medikal nedenler en önemli (%64) elenme nedeni olarak belirlenmiştir. sOnuÇ: Merkezimize başvuran canlı böbrek nakli verici adaylarının, en sık elenme nedeni medikal nedenler olarak tespit edilmiştir.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Exclusion Reasons of Living Kidney Donor Candidates: A Single-Center Experience

Oruç¹,

Tandogan²,

Karadayı³

et al. 2014

Turk Neph Dial Transpl

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“…The act of donation should not preclude the donor from obtaining medical insurance or increase the cost of insurance [41]. In the USA, the organ donor leave act was created in 1999 and entitles the donor for 30 days of paid leave.…”

Section: History and Examinationmentioning

confidence: 99%

Live Donor Kidney Transplantation Pearls: A Practical Review

Matter¹,

Abbas²,

Nagib³

et al. 2017

UNOAJ

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Living donation is "a gift of extraordinary value". The use of living donors for renal transplantation was critical for the early development of the field and preceded the use of cadaveric donors. Most donors are related genetically to the recipient, but there are an increasing percentage of cases, where donors are genetically unrelated like spouses, friends, or other emotionally related individuals. Ethical guidelines mandate that the living donors should not be coerced without any evidence of financial profit for the donor. Living donation has been associated with a higher success rate than that seen with cadaveric donation. Conclusion:In view of higher demand for transplantation and the lack of a parallel increase in the number of available cadaveric organs, living donation is important solution for patients to avoid long times on waiting list, and occasionally, even the need of dialysis so, much efforts are needed to encourage living donation rates.

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“…In their donor evaluation review, Pham et al (17) suggested that IFG or IGT be considered relative contraindications for donation and evaluated on an individual basis. The Asian Pacific Society of Nephrology guidelines make similar recommendations but further suggest that all "at risk" ethnic groups receive an OGTT (18).…”

Section: Transplant Guidelines For Donor Screening and Exclusionmentioning

confidence: 99%

Should Living Kidney Donor Candidates with Impaired Fasting Glucose Donate?

Vigneault

Asch

Bia

2011

Clinical Journal of the American Society of Nephrology

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SummaryAs the kidney transplant waiting list grows, the willingness of transplant centers to accept complex donors increases. Guidelines for the evaluation of living kidney donors exist but do not provide clear guidance when evaluating the complex donor. Although few transplant centers will approve donor candidates with impaired glucose tolerance and most, if not all, will deny candidates with diabetes, many will approve candidates with impaired fasting glucose (IFG). Furthermore, the demographic of living donors has changed in the past 10 years to increasingly include more nonwhite and Hispanic individuals who are at greater risk for future diabetes and hypertension. IFG may be more of a concern in potential donors whose nonwhite and Hispanic ethnicity already places them at greater risk. We review the definition of diabetes, diabetes prediction tools, and transplant guidelines for donor screening and exclusion as it pertains to impaired glucose metabolism, and additional ethnic and nonethnic factors to consider. We offer an algorithm to aid in evaluation of potential living donors with IFG in which ethnicity, age, and features of the metabolic syndrome play a role in the decision making.

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Evaluation of the Potential Living Kidney Donor

Cited by 29 publications

References 10 publications

Exclusion Reasons of Living Kidney Donor Candidates: A Single-Center Experience

Exclusion Reasons of Living Kidney Donor Candidates: A Single-Center Experience

Live Donor Kidney Transplantation Pearls: A Practical Review

Should Living Kidney Donor Candidates with Impaired Fasting Glucose Donate?

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