Evaluation of the physico-chemical properties of chitosan as a potential carrier for rifampicin, using voltammetric and spectrophotometric techniques

Santos, Ronaldo Oliveira dos; Santos, Neemias G.; Alves, José do Patrocínio Hora; Garcia, Carlos Alexandre Borges; Romão, Luciane C.P.; Arguelho, Maria Lara P.M.

doi:10.1016/j.bioelechem.2008.01.003

Cited by 17 publications

(7 citation statements)

References 24 publications

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“…The physical interaction of hydroquinone group of rifampicin with chitosan stabilized gold has been postulated. Santos et al have reported that the interaction of rifampicin with chitosan is strongly dependent on pH [49]. The rifampicin is strongly adsorbed by chitosan at pH less than the pKa of the drug, and hence, chitosan can be an efficient carrier for the controlled release of rifampicin in the intestinal tract.…”

confidence: 99%

Green Synthesis Of Gold Nanoparticles For controlled Delivery

Malathi¹,

Balakumaran²,

Kalaichelvan³

et al. 2013

Adv. Mater. Lett.

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Gold nanoparticles (AuNPs) have been synthesized by green method using chitosan as a reducing/capping agent. We designed a biocompatible carrier for controlled release of hydrophobic drugs. The designed carrier was prepared by using single oil-inwater (O/W) emulsion. The resulting AuNPs were characterized by UV-Vis spectroscopy (UV-Vis) and Fourier transform infrared spectroscopy (FTIR). The transmission electron microscopy (TEM) studies indicate the spherical nature of drug loaded nanoparticles with the size of 50nm while the average particle size of AuNPs is found to be 2-3nm. The chitosan capped AuNPs showed a surface plasmon resonance at 526nm. The FTIR spectra suggest that the amine group is mainly responsible for the reduction of tetrachloroauric acid and capping the AuNPs. The controlled release of rifampicin (RIF) was investigated by in vitro studies using phosphate buffer saline (PBS) at pH=7.4. The loading efficiency of drug molecule was found to be 71%. The encapsulated drugs were released at 37 °C temperature. The results have been fit into various mechanistic models and it is found that the Higuchi model fits in to the release behavior of RIF. Further, the antibacterial activity of RIF loaded nanoparticles was examined by Gram +ve (bacillus subtils) and Gram -ve (Pseudomonas aeruginosa) bacteria. The application of similar drug loaded nanocarrier for treating other diseases like cancer can also be investigated.

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confidence: 99%

Green Synthesis Of Gold Nanoparticles For controlled Delivery

Malathi¹,

Balakumaran²,

Kalaichelvan³

et al. 2013

Adv. Mater. Lett.

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“…The decrease in entrapment efficiency could be the lesser binding or incorporation of the drug into the chitosan matrix offered by the addition of TPP. Santos RHT et al reported that as the amino group of chitosan was unavailable for linking, the interaction of rifampicin with chitosan diminished [ 21 ].…”

Section: Resultsmentioning

confidence: 99%

Preparation, In Vitro Characterization, and In Vivo Pharmacokinetic Evaluation of Respirable Porous Microparticles Containing Rifampicin

Kundawala

Patel²,

Patel

et al. 2014

Sci. Pharm.

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This study aimed to prepare and evaluate rifampicin microparticles for the lung delivery of rifampicin as respirable powder. The microparticles were prepared using chitosan by the spray-drying method and evaluated for aerodynamic properties and pulmonary drug absorption. To control the drug release, tripoly-phosphate in different concentrations 0.6, 0.9, 1.2, and 1.5 was employed to get a sustained drug release profile. The microparticles were evaluated for drug loading, % entrapment efficiency, tapped density, morphological characteristics, and in vitro drug release studies. Aerosol properties were determined using the Andersen cascade impactor. Porous microparticles with particle sizes (d0.5) less than 10 μm were obtained. The entrapment of rifampicin in microparticles was up to 72%. In vitro drug release suggested that the crosslinked microparticles showed sustained release for more than 12 hrs. The drug release rate was found to be decreased as the TPP concentration was increased. The microparticles showed a fine particle fraction in the range of 55–63% with mass median aerodynamic diameter (MMAD) values below 3 μm. The in vivo pulmonary absorption of the chitosan microparticles suggested a sustained drug release profile up to 72 hrs with an elimination rate of 0.010 per hr. The studies revealed that the spray-dried porous microparticles have suitable properties to be used as respirable powder in rifampicin delivery to the lungs.

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“…All chemicals used in this work were of analytical grade and used without further purification. Solutions of pH 2.0 and 5.0, prepared by varying the percentages of an acid solution containing 0.1 mol L −1 acetic acid, 0.1 mol L −1 boric acid, and 0.1 mol L −1 phosphoric acid, and a basic solution containing 1.0 mol L −1 NaOH, according to Britton–Robinson (B–R) procedure 52, were used for pH studies. Captopril (CAP) and all chemicals were supplied by Merck.…”

Section: Methodsmentioning

confidence: 99%

Captopril Electrochemical Oxidation on Fluorine‐Doped SnO₂ Electrodes and Their Determination in Pharmaceutical Preparations

et al. 2010

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A novel application of fluorine-doped tin oxide (FTO) electrodes is reported in the present work. To this end, the captopril electrochemical oxidation mechanism on FTO electrodes at various pH and its determination in pharmaceutical preparations was investigated. Captopril oxidation on FTO proceeds at pH between 2.0 and 4.0. The study revealed that interferences for captopril determination in pharmaceutical samples was totally suppressed using these electrode materials. Voltammetric survey showed an anodic peak at about 0.375 V (Ag j AgCl) for captopril oxidation, that takes place through an EC process at pH interval 2.0-4.0. The investigation demonstrated that captopril oxidation occurs through protonated species and these electroactive species interact by adsorption on FTO electrodes, with a large heterogeneous rate constant and a mechanism involving 1H + /1e À in the global reaction. Moreover, a captopril sensor based upon FTO electrodes, with a linear range miliMolar, is proposed. These electrodes are promising candidates for the efficient electrochemical determination of captopril in pharmaceutical preparations.

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Evaluation of the physico-chemical properties of chitosan as a potential carrier for rifampicin, using voltammetric and spectrophotometric techniques

Cited by 17 publications

References 24 publications

Green Synthesis Of Gold Nanoparticles For controlled Delivery

Green Synthesis Of Gold Nanoparticles For controlled Delivery

Preparation, In Vitro Characterization, and In Vivo Pharmacokinetic Evaluation of Respirable Porous Microparticles Containing Rifampicin

Captopril Electrochemical Oxidation on Fluorine‐Doped SnO₂ Electrodes and Their Determination in Pharmaceutical Preparations

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Evaluation of the physico-chemical properties of chitosan as a potential carrier for rifampicin, using voltammetric and spectrophotometric techniques

Cited by 17 publications

References 24 publications

Green Synthesis Of Gold Nanoparticles For controlled Delivery

Green Synthesis Of Gold Nanoparticles For controlled Delivery

Preparation, In Vitro Characterization, and In Vivo Pharmacokinetic Evaluation of Respirable Porous Microparticles Containing Rifampicin

Captopril Electrochemical Oxidation on Fluorine‐Doped SnO2 Electrodes and Their Determination in Pharmaceutical Preparations

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Captopril Electrochemical Oxidation on Fluorine‐Doped SnO₂ Electrodes and Their Determination in Pharmaceutical Preparations