Evaluation of the overall impact of antibiotics growth promoters on broiler health and productivity during the medication and withdrawal period

Hamid, Humera; Zhao, Li Hua; Y, G; Li, W X; Shi, Huan; Zhang, J Y; Ji, Cheng; G, Q

doi:10.3382/ps/pey598

Cited by 17 publications

(12 citation statements)

References 58 publications

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“…Although some studies have shown the positive effects of antibiotic growth promoters on poultry production [15,20], this study found that short-term supplementation of antibiotic growth promoters in the early stages did not improve growth performance. That has also been reported before [21].…”

Section: Discussioncontrasting

confidence: 67%

The Effects of Flavomycin and Colistin Sulfate Pre-Treatment on Ileal Bacterial Community Composition, the Response to Salmonella typhimurium and Host Gene Expression in Broiler Chickens

Yang

Dong

et al. 2019

Microorganisms

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The composition of the bacterial community affects the intestinal health and growth performance of broiler chickens. The main purpose of this study was to explore the effects of flavomycin and colistin sulfate on the resistance to Salmonella typhimurium infection, ileal bacteria and intestinal health. In total, 396 1-day-old broiler chickens were randomly divided into six groups. Two groups were fed each one of the diets—the control diet (CON), the flavomycin at 10 mg/kg diet (AntiG+), and the colistin sulfate at 40 mg/kg diet (AntiG−), for 5 days. Then, one of each of the two groups was challenged with S. typhimurium on the 8th day; these were named CONS, AntiG+S and AntiG−S, respectively. The results showed that S. typhimurium significantly reduced the feed intake and body weight gain, and increased the feed conversion ratio (p < 0.05). It also increased the inflammatory expressions of NF-κB and MyD88 genes (p < 0.05); and reduced the expressions of claudin-1, occludin and mucin-2 (p < 0.05) tight junction genes in the intestines. S. typhimurium significantly reduced ileal bacterial diversity indexes of observed-species, chao1 and Shannon (p < 0.05). Compared with AntiG+S group, AntiG−S group increased the body weight gain of broiler chickens (p < 0.05), reduced the expression of inflammatory genes (p < 0.05) and intestinal permeability to fluorescein isothiocyanate (p < 0.05). AntiG-S group also improved the ileal bacterial diversity indexes of observed-species and Shannon (p < 0.05). There were many significant correlations between intestinal bacteria, intestinal gene expressions and intestinal morphology (p < 0.05). This study indicated that pre-constructed AntiG− bacteria could against a S. typhimurium infection by inhibiting the expressions of intestinal inflammation genes and increasing the diversity of intestinal bacteria.

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Section: Discussioncontrasting

confidence: 67%

The Effects of Flavomycin and Colistin Sulfate Pre-Treatment on Ileal Bacterial Community Composition, the Response to Salmonella typhimurium and Host Gene Expression in Broiler Chickens

Yang

Dong

et al. 2019

Microorganisms

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“…( Zhou et al., 2013a ). Therefore, antibiotic as growth promoters in animal feed has been banned by Sweden in 1986 and then by the European Union in 2006 ( Hamid et al., 2019 ). The situation in China began in 2015 and from July of 2020, enterprises will stop producing commercial feeds containing antibiotic growth promoters.…”

Section: Discussionmentioning

confidence: 99%

Systematic analysis of occurrence, density and ecological risks of 45 veterinary antibiotics: Focused on family livestock farms in Erhai Lake basin, Yunnan, China

Zhi

Shen

Zhou³

et al. 2020

Environmental Pollution

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Antibiotic pollution from family animal farms is often neglected, but the waste from these farms usually caused more harm to the surroundings because arbitrary discharge without effective disposal. The pollution status and ecological risks of 45 veterinary antibiotics on 33 family animal farms in Dali city, Erhai Lake basin of China, were firstly delivered. The results showed that antibiotic contamination was prevalent in different environmental mediums (feed, manure, wastewater and soil) on these family farms. Manure had highest antibiotic levels among all the environmental mediums. Tetracyclines (TCs) usually had higher concentrations (ND-404.95 mg/kg) than the other classes, among which chlorotetracycline (CTC) was the dominant type. Among different animal species, target 13 pig farms had the highest antibiotic concentrations, the most total types and unique types of antibiotics, which were followed by target 11 chicken farms then target 9 cattle farms. The antibiotic densities of animal waste were calculated by per animal, which showed that pig waste presented high density; and family chicken farms were characterized by quinolone antibiotics (QAs) and macrolide antibiotics (MAs) pollution. For the antibiotic ecological risks in effluent water, oxytetracycline (OTC), CTC, ofloxacin (OFL), enrofloxacin (ENR), ciprofloxacin (CIP) and sulfamethoxazole (SMX2) exhibited much more toxic effects on algae. OTC and doxycycline (DXC) posed high risk for invertebrate; while no antibiotic caused high ecological risk for fish. Some antibiotics were quantitatively detected in the soil but no antibiotic posed obvious ecological risks on soils. However, the interaction of synergistic or antagonistic effects between different antibiotics should be brought to the forefront. This study gave some information of antibiotic pollution on family livestock farms, which indicated that animal waste from family farms was indeed an important pollution source of antibiotics for the environment.

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“…Unfortunately, the ban on the use of antibiotics has caused slower growth of livestock and poultry, worsened feed efficiency and increased the incidence of disease, which in turn has increased the amount of antibiotic treatment, increased the treatment costs, and reduced the economic benefits ( Castanon, 2007 ; Zhang et al., 2017 ). Our previous study found that the withdrawal of antibiotic growth promoters (AGP) from feed induces poor growth performance, but that the supplementation of AGP has adverse effects on the meat quality of broiler chickens ( Hamid et al, 2019 ). Therefore, concerns over the increasing emergence of antibiotic resistance and the unreasonable use of antibiotics have prompted efforts to develop so-called alternatives to antibiotics ( Cheng et al., 2014 ).…”

Section: Introductionmentioning

confidence: 99%

Dietary supplementation with acidifiers improves the growth performance, meat quality and intestinal health of broiler chickens

et al. 2021

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This experiment was conducted to study the effects of dietary supplementation with acidifiers on the growth performance, meat quality, and intestinal health of broiler chickens. A total of 648 male Arbor Acres broiler chickens at 1 d old were randomly divided into 6 groups, and each group consisted of 6 replicates with 18 broilers per replicate. The dietary treatments were as follows: negative control (NC, the basal diet), NC + antibiotic (enramycin, 8 mg/kg, positive control [PC]), NC + phosphoric acid (PA, 0.1, 0.2, and 0.3 g/kg), and NC + lactic acid (LA, 0.3 g/kg). The feeding trial lasted for 42 d. The results showed that the feed-to-gain ratio of the NC + acidifier groups was lower than that of the NC and PC groups from 1 to 42 d ( P < 0.05). Compared with the values in the NC group, the pH of breast muscle was significantly higher in the NC + PA (0.2 g/kg) and LA (0.3 g/kg) groups ( P < 0.05), and the cooking loss was lower in the breast muscle of the NC + PA (0.1 g/kg) and LA (0.3 g/kg) groups ( P < 0.05). In addition, the shear force of the breast muscle and thigh muscle and the pH value in the crop, gizzard and duodenum of the antibiotic and acidifier groups were significantly decreased ( P < 0.05). Moreover, the trypsin, chymotrypsin, and lipase activities of the duodenum in the NC + PA (0.2 and 0.3 g/kg) groups, as well as the villus height-to-crypt depth (VH:CD) ratio of the duodenum in the NC + PA (0.1 g/kg) group was significantly greater ( P < 0.05) compared with those in the NC group. Meanwhile, the number of total aerobic bacteria, Escherichia coli and Salmonella in the cecum of the NC + PA (0.1 g/kg) and LA (0.3 g/kg) groups were decreased ( P < 0.05). Collectively, diet supplementation with acidifiers could improve the growth performance, meat quality, and intestinal health of broilers, in which the effects of PA (0.1 g/kg and 0.2 g/kg) are better than the other supplementations.

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Evaluation of the overall impact of antibiotics growth promoters on broiler health and productivity during the medication and withdrawal period

Cited by 17 publications

References 58 publications

The Effects of Flavomycin and Colistin Sulfate Pre-Treatment on Ileal Bacterial Community Composition, the Response to Salmonella typhimurium and Host Gene Expression in Broiler Chickens

The Effects of Flavomycin and Colistin Sulfate Pre-Treatment on Ileal Bacterial Community Composition, the Response to Salmonella typhimurium and Host Gene Expression in Broiler Chickens

Systematic analysis of occurrence, density and ecological risks of 45 veterinary antibiotics: Focused on family livestock farms in Erhai Lake basin, Yunnan, China

Dietary supplementation with acidifiers improves the growth performance, meat quality and intestinal health of broiler chickens

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