Evaluation of the oral toxicity of acetaldehyde and formaldehyde in a 4-week drinking-water study in rats

Toxic effects of formaldehyde on the urinary system

“…It was found that FA administered orally to rats caused mucosal ulcers, necrosis, hemorrhage and perforation in the gastrointestinal system and, subsequently, the development of metabolic acidosis, circulatory failure, hematuria, anuria and renal papillary necrosis. [41] It was observed that exposing renal cell cultures from monkeys to FA resulted in depression of RNA synthesis and failure of DNA transcriptiontermination. [42] Sub-chronic inhalation of FA affects the main metabolic pathways, by which glucose participates in altering the activities of glucose-6-phosphate dehydrogenase (G6PD), lactate dehydrogenase (LDH), malate dehydrogenase (MDH) and hexokinase (HK) enzymes.…”

Toxicological effect of formalin as food preservative on kidney and liver tissues in mice model

“…However, we did not observe any tumor in liver, kidney or any other organ. Some work of formalin through drinking water and food stuff on stomach and other tissue of mice, dogs and rat demonstrated little effect except for mild pharyngeal and gastric discomfort, significant increase in the thickness of the stomach lining epithelium [26]and irritation in mucus membrane, but such harmful effect was also alleviated' by diluting the formaldehyde prior to ingestion [27], [28].Inflammatory lesions in digestive system following oral administration formaldehyde has been reported in claves [29] and rats [30], [31], [32].The current observation showed that nature and intensity of histological alteration exposure through oral introduction of formalin are dose and time Toxicological effect of formalin as food preservative on kidney and liver tissues in mice model.…”

Acetaldehyd [MAK Value Documentation in German language, 2008]

“…Nach 4-wöchiger Gabe an Ratten traten ab 675 mg/kg KG und Tag Erniedrigungen des Futter-und Wasserverbrauchs sowie Hyperkeratosen des Vormagens auf. Es ergab sich ein NOAEL von 125 mg/kg KG und Tag (Til et al 1988). Die 11-wöchige orale Aufnahme führte bei der gleichen Spezies ab 500 mg/kg KG und Tag zur Akkumulation von Fetten und zu entzündlichen Veränderungen in der Leber (Jokelainen et al 2000;Matysiak-Budnik et al 1996).…”