2009
DOI: 10.1590/s0102-695x2009000200005
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Evaluation of the molluscicidal and Schistosoma mansoni cercariae activity of Croton floribundus extracts and kaurenoic acid

Abstract: RESUMO: "Avaliação das atividades moluscicida e cercaricida (Schistosoma mansoni) dos extratos de Croton floribundus e do ácido caurenóico". Extratos de Croton fluribundus (Euphorbiaceae), ácido caurenóico e dois derivados do ácido caurenóico foram avaliados como moluscicida, cercaricida e também foi verificada a letalidade destas amostras frente a larvas de Artemia salina Leach. Nestes ensaios foram observadas significantes atividades moluscicida e cercaricida associadas a uma reduzida toxicidade frente ao ca… Show more

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Cited by 14 publications
(9 citation statements)
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“…The molluscicidal activity was not observed for both extracts tested on Biomphalaria glabrata snails in the evaluated concentrations (200, 100 and 50 µg/ml). Medina et al (2009) reported significant molluscicidal and cercaricidal activities against adult Biomphalaria glabrata snails and Schistosoma mansoni cercariae for alcoholic extracts of leaves and barks of C. floribundus and the isolated compound, kaurenoic acid. The lack of activity observed in our study can be related to the non-production of active metabolites in the studied plant, since the production of secondary metabolites in plants can be influenced by several factors like seasonality, type of soil, weather, rainfall, radiation or any other condition (Al-Zanbagi et al, 2000).…”
Section: Resultsmentioning
confidence: 99%
See 1 more Smart Citation
“…The molluscicidal activity was not observed for both extracts tested on Biomphalaria glabrata snails in the evaluated concentrations (200, 100 and 50 µg/ml). Medina et al (2009) reported significant molluscicidal and cercaricidal activities against adult Biomphalaria glabrata snails and Schistosoma mansoni cercariae for alcoholic extracts of leaves and barks of C. floribundus and the isolated compound, kaurenoic acid. The lack of activity observed in our study can be related to the non-production of active metabolites in the studied plant, since the production of secondary metabolites in plants can be influenced by several factors like seasonality, type of soil, weather, rainfall, radiation or any other condition (Al-Zanbagi et al, 2000).…”
Section: Resultsmentioning
confidence: 99%
“…The fruits are considered tonic. According Medina et al (2009), the alcoholic extracts of leaves and barks and the isolated compound, kaurenoic acid, showed significant molluscicidal and cercaricidal activities against adult Biomphalaria glabrata snails and Schistosoma mansoni cercariae, respectively. In other work, the ent-kaur-16-en-6α,19-diol isolated from hexane extract of root bark showed moderate effect against three cancer cell lines: MDA-MB-435 (melanoma), HCT-8 (colorectal adenocarcinoma) and HCT-116 (colorectal adenocarcinoma) (Uchoa et al, 2013).…”
Section: Introductionmentioning
confidence: 99%
“…A previous study with CUR also demonstrated high activity on S japonicum cercariae, with 100% cercariae mortality at a concentration of 8 μg mL −1 after 30 min . Other compounds, such as kaurenoic acid isolated from Croton floribundus , have also demonstrated the cercaricidal effect on S. mansoni cercariae, with 100% cercariae mortality at a concentration of 100 μg mL −1 after 1 h of exposure . Although PZQ is not used to eliminate snail breeding cercariae, this compound was used during the present study as positive control.…”
Section: Discussionmentioning
confidence: 99%
“…30 Other compounds, such as kaurenoic acid isolated from Croton floribundus, have also demonstrated the cercaricidal effect on S. mansoni cercariae, with 100% cercariae mortality at a concentration of 100 μg mL −1 after 1 h of exposure. 48 Although PZQ is not used to eliminate snail breeding cercariae, this compound was used during the present study as positive control. In agreement with other reports, PZQ causes 100% mortality of S. mansoni and S. japonicum cercariae at concentrations of 1, 8 and 12.5 μg mL −1 between 0.30 and 3 h. 30,36,49 CUR toxicity related to other environment organisms was not evaluated in this study; however, CUR showed no toxic effect and systemic abnormalities in a higher dose (1.5 mg) against Labeo rohita fish.…”
Section: Discussionmentioning
confidence: 99%
“…glabrata snails at concentrations of 50 ppm [263]. glabrata adult snails [269]. glabrata and their eggs [264,265].…”
Section: Schistosomiasismentioning
confidence: 99%