Evaluation of the mean platelet volume in children with familial Mediterranean fever

Abstract

To evaluate the Mean Platelet Volume (MPV) levels in children diagnosed with familial Mediterranean fever (FMF), during attack and attack-free periods. The records of a total of 117 children with FMF, diagnosed using the Tel-Hashomer criteria, have been scanned. The study consisted of 53 patients during an attack (group 1), 64 patients in attack-free period (group 2), and 57 healthy controls (group 3). Erythrocyte sedimentation rate, C-reactive protein, white blood cell count, platelet count, and MPV levels were retrospectively recorded. The MPV and platelet values in FMF patients during attack (group 1) and FMF patients during attack-free periods (group 2) have been found to be significantly higher than those of the health control group (group 3). Positive correlation has been found between the MPV and platelet values in Group 1 and the disease's severity score (r = 0.224, and r = 0.268, respectively). Positive correlation (r = 0.528, and r = 0.485, respectively) has been also identified between MPV and blood platelet count in patients in Group 1 and 2. No correlation was found between the Colchicine treatment period and MPV (r = -0.005). The MPV values in the complete group of FMF diagnosed children have been found to be much higher compared to those in healthy children. As a consequence, we consider the MPV value as a useful marker that demonstrates the risk of early stage atherosclerosis in children with FMF.

Assessment of epicardial adipose tissue thickness and the mean platelet volume in children with familial Mediterranean fever

“…Usefulness of MPV in assessment of atherosclerotic risk in cases with FMF was also investigated. In accordance with our results, most of the studies found significantly higher MPV values in FMF patients and stated that FMF is associated with increased risk of atherosclerosis [6,9,10]. MPV values were found higher even in attack-free FMF cases.…”

“…Mean platelet volume (MPV) and epicardial adipose tissue (EAT) thickness are novel parameters used in prediction of the risk of atherosclerosis [3,6-8]. Albeit contradictory results have been reported, there are some studies investigating the usefulness of MPV in assessment of atherosclerotic risk in cases with FMF [6,9,10]. However, no study evaluating EAT thicknesses of FMF patients was reported so far.…”

Usefulness of Mean Platelet Volume and Neutrophil-to-Lymphocyte Ratio for Evaluation of Children with Familial Mediterranean Fever

“…Outcomes of clinical and subclinical inflammation are unclear during FMF attack and in the attack-free period. As in other clinical entities accompanied by inflammation, FMF patients are at an increased risk of atherosclerosis development [6,12,13]. …”

Neutrophil to Lymphocyte Ratio and Mean Platelet Volume as Inflammatory Indicators in Systemic Lupus Erythematosus Nephritis

“…22,23 Moreover, NLR and MPV had higher levels at the attack periods in familial Mediterranean fever patients. 24,25 High levels of MPV and NLR have been found as a predictor for gastrointestinal bleeding in the Henoch-Schonlein purpura. 26,27 Decreased MPV and NLR have been shown with the treatment of rheumatoid arthritis and ankylosing spondylitis.…”