Evaluation of the &lt;i&gt;in vitro&lt;/i&gt; combined antibacterial effect of the leaf extracts of &lt;i&gt;Bryophyllum pinnatum&lt;/i&gt; (Fam: crassulaceae) and &lt;i&gt;Ocimum gratissimum&lt;/i&gt; (Fam: labiatae)

Ofokansi, KC; Esimone, CO; Anele, C R

doi:10.4314/pprj.v9i1.35242

Cited by 33 publications

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“…The presence of phenolic compounds in the plant indicates the antimicrobial properties. In the present research, the author also observed the antibacterial assay, which agrees with the findings of Ofokansi et al (2005). The phytochemicals are Known to have antimicrobial properties (Gupta et al, 2010).…”

Section: Resultssupporting

confidence: 81%

Phytochemical analysis and antimicrobial evaluation of Andrographis lineata Nees leaves and stem extracts

Alagesaboopathi¹

2011

Afr. J. Pharm. Pharmacol.

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The present investigation was designed to evaluate the antibacterial, antifungal properties and physiochemical screening of the various leaves and stem extracts of Andrographis lineata. Acetone, ethanol, methanol, petroleum ether and chloroform extracts of shade dried plant leaf and stem of A. lineata were tested for antibacterial, antifungal and phytochemical analysis. The antibacterial properties of various extracts of leaves and stem of A. lineata were assayed using the standard disc diffusion method, against five strains of bacterial species, namely, Proteus vulgaris, Escherichia coli, Klebsiela pneumoniae, Staphylococcus aureus and Pseudomonas aeruginosa. Among different solvent extracts studied, the methanol leaf extract showed highest antibacterial activity against staphylococcus aureus (19.41 mm); followed by petroleum ether extract (18.30 mm). The highest inhibition zone observed for acetone extract of A. lineata leaves against P. vulgaris was 17.40 mm followed by ethanol extract (16.10 mm). The highest activity of chloroform extract against K. pneumoniae was 14.07 mm. Phytochemical investigation confirmed the presence of flavonoids, saponins, gums and mucilages, triterpenoids, steroids, glycosides, phenolic compounds and tannins. The acetone leaf extracts of A. lineata showed highest antifungal activity against Penicillium pinophilum (13.40 mm). The methanol leaf extracts showed maximum activity against Aspergillus niger (12.15 mm). The petroleum ether leaf extracts showed highest activity against P. pinophilum (12.11 mm). The ethanol leaf extracts showed significant activity against Aspergillus flavus (11.24 mm). The chloroform leaf extracts showed higher activity against A. niger (9.75 mm). The leaf extract showed more inhibitory effect than the stem extracts. The present research justifies the claimed uses of this herb in the traditional system of medicine to treat different diseases.

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Section: Resultssupporting

confidence: 81%

Phytochemical analysis and antimicrobial evaluation of Andrographis lineata Nees leaves and stem extracts

Alagesaboopathi¹

2011

Afr. J. Pharm. Pharmacol.

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“…In vitro experiments using the agar-well diffusion method demonstrated the sensitivity of several bacteria and fungi to hot water and methanolic extracts as well as to flavonoids of B. pinnatum [81,82]. Several compounds, including a phenanthrene [46], α-rhamnoisorobin (23), and further kaempferol rhamnosides (17,(19)(20)(21)(22) [28], showed antimicrobial activity.…”

Section: Antimicrobial Activitymentioning

confidence: 99%

Bryophyllum pinnatum and Related Species Used in Anthroposophic Medicine: Constituents, Pharmacological Activities, and Clinical Efficacy

et al. 2016

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ReviewsThis document was downloaded for personal use only. Unauthorized distribution is strictly prohibited.Bryophyllum (see below) [4]. While these reviews describe various compounds and bioactivities, none of them addresses the pharmacological and clinical data that support the therapeutic use of Bryophyllum preparations in European countries. The present review focuses on B. pinnatum, but the few data available on Bryophyllum daigremontianum, Bryophyllum delagoense, and the hybrid Bryophyllum daigremontianum x tubiflorum have also been included. The German homeopathic pharmacopeia (HAB) 2014 [5] lists the two species B. pinnatum and B. daigremontianum as officinal in its monography "Bryophyllum Rh", and both have been used in AM. B. delagoense was introduced in the 1980s as an anthroposophic medicinal product in Germany, primarily for sedative purposes (Personal communication, Dr. med. Siegward-M. Elsas, see Acknowledgments). Botany

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“…With respect to pharmacological properties of B. pinnatum, antileishmanial [12], antiulcer [13], antibacterial [14,15], antitumor promoting [16], immunosuppressive [17], and antihypertensive effects [18] have been reported. Compounds identified in the plant include flavonoids, triterpenes, phytosterols, bufadienolides, fatty acids, and minerals [19].…”

Section: Introductionmentioning

confidence: 99%

Two New Flavonol Glycosides and a Metabolite Profile of Bryophyllum pinnatum, a Phytotherapeutic Used in Obstetrics and Gynaecology

et al. 2013

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Bryophyllum pinnatum is a succulent perennial plant native to Madagascar which is used in anthroposophical medicine to treat psychiatric disorders and as a tocolytic agent to prevent premature labour. We performed a metabolite profiling study in order to obtain a comprehensive picture of the constituents in B. pinnatum leaves and to identify chromatographic markers for quality control and safety assessment of medicinal preparations. Preliminary HPLC-PDA-ESIMS analyses revealed that flavonoid glycosides were the main UV-absorbing constituents in the MeOH extract of B. pinnatum. Two phenolic glucosides, syringic acid -D-glucopyranosyl ester (1) and 4'-O--D-glucopyranosyl-cis-p-coumaric acid (2), as well as nine flavonoids (3-11) including kaempferol, quercetin, myricetin, acacetin, and diosmetin glycosides were unambiguously identified by 1H and 2D NMR analysis after isolation from a MeOH extract. The flavonol glycosides quercetin 3-O--L-arabinopyranosyl-(1 → 2)--L-rhamnopyranoside 7-O--D-glucopyranoside (3) and myricetin 3-O--L-arabinopyranosyl-(1 → 2)--L-rhamnopyranoside (4) were new natural products. With the aid of HPLC-PDA-APCIMS and authentic references isolated from the related species B. daigremontianum, the presence of four bufadienolides, bersaldegenin-1-acetate (12), bryophyllin A (13), bersaldegenin-3-acetate (14), and bersaldegenin-1,3,5-orthoacetate (15) AbstractBryophyllum pinnatum is a succulent perennial plant native to Madagascar which is used in anthroposophical medicine to treat psychiatric disorders, and as a tocolytic agent to prevent premature labour. We performed a metabolite profiling study in order to obtain a comprehensive picture of the constituents in B. pinnatum leaves, and to identify chromatographic markers for quality control and safety

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Evaluation of the <i>in vitro</i> combined antibacterial effect of the leaf extracts of <i>Bryophyllum pinnatum</i> (Fam: crassulaceae) and <i>Ocimum gratissimum</i> (Fam: labiatae)

Cited by 33 publications

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Phytochemical analysis and antimicrobial evaluation of Andrographis lineata Nees leaves and stem extracts

Phytochemical analysis and antimicrobial evaluation of Andrographis lineata Nees leaves and stem extracts

Bryophyllum pinnatum and Related Species Used in Anthroposophic Medicine: Constituents, Pharmacological Activities, and Clinical Efficacy

Two New Flavonol Glycosides and a Metabolite Profile of Bryophyllum pinnatum, a Phytotherapeutic Used in Obstetrics and Gynaecology

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