Evaluation of the leishmanicidal activity of plants used by Peruvian Chayahuita ethnic group

Estevez, Yannick; Castillo, Denis; Pisango, M. Tangoa; Arévalo, Jorge; Rojas, Rosario; Albán, Joaquina; Deharo, Eric; Bourdy, Geneviève; Sauvain, Michel

doi:10.1016/j.jep.2007.08.007

Cited by 82 publications

(67 citation statements)

References 29 publications

(30 reference statements)

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“…Estevez et al (2007) studying the leishmanicidal activity in vitro of 27 plant extracts from the Amazon region, obtained results in only two species against the amastigote form of L. amazonensis, and in only one specie against the promastigote form. Ahua et al (2007) studying 64 extracts of 21 plants used in traditional medicine in Africa, obtained significant activity in only seven extracts of six different plants, against both amastigotes and promastigotes of L. major.…”

Section: Discussionmentioning

confidence: 99%

“…Some natural compounds with antileishmanial activity are being investigated (Lamidi et al, 2005;Estevez et al, 2007) corresponding to the following groups: alkaloids, terpens, quinones, lactones, cumarins, chalcones, tetralones, lignins and Effect of ethyl acetate extract from husk fiber water of Cocos nucifera in Leishmania braziliensis infected hamsters José C. C. Freitas et al infected with L. braziliensis and showed inhibitory activity in the two development stages, promastigotes and amastigotes forms, of L. amazonensis.…”

Section: Discussionmentioning

confidence: 99%

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Effect of ethyl acetate extract from husk fiber water of Cocos nucifera in Leishmania braziliensis infected hamsters

Freitas¹,

Nunes-Pinheiro²,

Pessoa³

et al. 2011

Rev. bras. farmacogn.

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Abstract:The objective of this study was to evaluate the treatment with ethyl acetate extract (EAE) from husk fiber water of Cocos nucifera L., Arecaceae, in L. braziliensis (Lb) infected hamsters. Twelve male hamsters were randomly allocated in three groups (n=4): G1 received only EAE; G2 was infected with Lb only and G3 received EAE after Lb infection. The infection was carried 28 days prior to the treatment with EAE, which was administrated (0.2 mL, 300 mg.kg -1 ) for 21 consecutive days. Infection was evaluated through skin lesions and infected footpad edema. Haematological evaluation was done on -28 th , 0 and 21 st days. Imprint footpad and lymph node weight were evaluated on 21 st day. Lb infection significantly inhibited the peripheral leukocytes blood. However, neutrophils and lymphocytes values did not have significant alterations. G3 presented eosinophilia in relation to G2. The treatment with EAE did not reduce edema of infected footpad neither weight of drainage lymph node. Infected footpad imprints revealed amastigotes forms and cellular infiltration. Animals from G3 presented skin lesions on 7 th day, shown a reduction of these lesions in day 14. Therefore, the treatment with EAE did not alter the etiological agent elimination in these conditions. However, EAE presents a healing activity in this experimental model.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Effect of ethyl acetate extract from husk fiber water of Cocos nucifera in Leishmania braziliensis infected hamsters

Freitas¹,

Nunes-Pinheiro²,

Pessoa³

et al. 2011

Rev. bras. farmacogn.

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show abstract

“…This would create a positive cycle of community consultations, thus shortening the time it takes for people to consult a doctor. As well as this, there has been research that analysed herbal remedies in the treatment of leishmaniasis in Peru [20]. Data such as this could be considered when informing patients of more attractive alternatives than the herbal remedies that currently seem to be used.…”

Section: Home Treatmentmentioning

confidence: 99%

The Help Seeking Behaviours of Patients with Ulcerative Skin Lesions before Consultation in Yurimaguas, Peru

Goldring

Wildt²,

Lindenmeyer³

et al. 2015

J Anc Dis Prev Rem

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Background: In a tropical setting such as Peru, skin ulcers are commonly caused by infectious diseases such as leishmaniasis. Early treatment results in improved patient outcomes. By exploring the health beliefs and behaviours of a patient it is possible to identify barriers to healthcare that prevent early treatment. These barriers could be addressed by public health schemes and also assessed quantitatively. To date there has been no research regarding this topic.

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“…Experiments were conducted on axenic amastigotes of Leishmania amazonensis (strain MHOM/BR/76/LTB-012) and on luciferaseexpressing axenic amastigotes of L. infantum kindly given by JL Lemesre (MHOM/MA/67/ITMAP-263). 14,15 Axenically grown amastigotes were maintained by weekly sub-passages in MAA/20 medium 16 at 37 1C with 5% CO 2 in 25 cm 2 tissue culture flasks. Cultures were initiated with 5 Â 10 5 amastigotes (promastigotes) ml À1 in 25 cm 2 tissue culture flasks with 5 ml of medium.…”

Section: Biological Activitiesmentioning

confidence: 99%

Antibacterial, antifungal and antileishmanial activities of indolone-N-oxide derivatives

Ibrahim¹,

Furiga²,

Najahi³

et al. 2012

J Antibiot

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Evaluation of the leishmanicidal activity of plants used by Peruvian Chayahuita ethnic group

Cited by 82 publications

References 29 publications

Effect of ethyl acetate extract from husk fiber water of Cocos nucifera in Leishmania braziliensis infected hamsters

Effect of ethyl acetate extract from husk fiber water of Cocos nucifera in Leishmania braziliensis infected hamsters

The Help Seeking Behaviours of Patients with Ulcerative Skin Lesions before Consultation in Yurimaguas, Peru

Antibacterial, antifungal and antileishmanial activities of indolone-N-oxide derivatives

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