Evaluation of the L'vov platform and matrix modification for the determination of aluminium in serum

Bettinelli, M.; Baroni, U.; Fontana, F; Poisetti, Piergiorgio

doi:10.1039/an9851000019

Cited by 41 publications

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“…For Cu> the situation was a little different; we tried to find an interference-free analyte line with relatively low sensitivity due to the high Cu> concentration. The analyte line at 216.953 nm seemed to be a good choice for these purposes [3][4][5]. Althought the ratio [Cu>]/[Cu>] during the electrolysis of copper might be high enough to change the emission and interference levels/patterns, due to the role of Cu> as an intermediate, the effect of Cu> can be neglected since Cu> is not very stable in sulphuric acid solutions due to its disproportioning property and the duration of sample preparation [7-8].…”

Section: Resultsmentioning

confidence: 99%

Determination of antimony, arsenic, bismuth and copper by inductively coupled plasma atomic emission spectrometry in the electrorefining of copper

Piippanen

Tummavuori

1996

Analytical and Bioanalytical Chemistry

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Inductively coupled plasma atomic emissionspectrometry (ICP-AES) has been applied as a rapid and routine method for the analysis of process electrolytes in the electrorefining of copper. Antimony, arsenic, bismuth and copper have been selected as major electrolyte constituents. For these elements profound statistical studies of spectral and interelement effects have been carried out. For As, Bi and Sb two analyte wavelengths have been selected, and for Cu one relatively insensitive analyte line has been chosen due to the high Cu concentration in samples. Best analytical lines were: As at 193.759 nm, Bi at 306.772 nm, Sb at 206.833 nm and Cu at 216.953 nm. Multiple linear regression proved to be very capable in the search of the best analytical wavelength and identifying interfering elements. Using simple acid based standards all elements investigated can be determined separately in complicated matrices with satisfactory results. Differences between true values and measured values can be partly eliminated by appropriate calculational methods.

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Section: Resultsmentioning

confidence: 99%

Determination of antimony, arsenic, bismuth and copper by inductively coupled plasma atomic emission spectrometry in the electrorefining of copper

Piippanen

Tummavuori

1996

Analytical and Bioanalytical Chemistry

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“…Em geral, a concentração salina nessas soluções é da ordem de 400 g L -1 , o que dificulta a determinação 7 . As técnicas de detecção mais utilizadas são fluorescência de raios-X 8 , cromatografia líquida 9 , polarografia 10 , análise por ativação de nêu-trons 11 e espectrometria de absorção atômica em forno de grafite [12][13] . A espectrofotometria UV-Vis também tem sido empregada, recorrendo a uma etapa de separação e pré-concentração em linha baseada no processo de análise química por injeção em fluxo (FIA) 14 .…”

Section: Introductionunclassified

Determinação espectrofotométrica de alumínio em concentrados salinos utilizados em hemodiálise empregando pré-concentração em fluxo

Pereira¹,

Reis²

2002

Quím. Nova

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Recebido em 8/8/01; aceito em 27/2/02 SPECTROPHOTOMETRIC ALUMINIUM DETERMINATION IN HIGH SALTS CONCENTRATIONS SOLUTION USED IN HEMODYALISIS EMPLOING PRECONCENTRATION IN FLOW INJECTION.An automatic flow injection procedure for spectrophotometric aluminium determination in purified water and solutions containing high salts concentrations used for hemodyalisis treatment was developed. The method was base on reaction of Al 3+ with cianine eriochrome R (ECR) after preconcentration using the AG50W-X8 cationic-exchange resin. Elution was carried out using a 1 % (m/v) calcium chloride solution. The manifold comprised an automatic proporcional injector controlled by a computer equipped with an eletronic interface and software written in QuicBASIC 4.5 with facilities to control the injector and perform data acquisition. Samples with concentration ranging from 4.96 to 19.90 µg L -1 Al were analyzed and recoveries between 88 and 113% were obtained by using the standard addition method. Other profitable analytical characteristics such as a relative standard deviation 1.3 % (n = 10) for a typical sample 14.5 µg L -1 Al, a linear response ranging up to 60.0 µg L -1 Al, and a sampling throughput of 10 determinations per hour were achieved. A detection limit of 4.2 µg L -1 Al was estimated as suggested by IUPAC.Keywords: preconcentration; aluminium; hemodyalisis. INTRODUÇÃOO alumínio é o terceiro elemento mais abundante na crosta terrestre 1 e sua presença em vegetais, utensílios domésticos, partículas de pó e na água pode ser facilmente verificada. Em vista disso, cerca de 10 a 100 mg desse elemento são ingeridos diariamente pelo ser humano. Embora essa quantidade pareça alta nem toda ela atinge a corrente sangüínea, pois apenas uma pequena parte é reabsorvida, sendo posteriormente eliminada pelos rins. Não há função bioquí-mica conhecida que seja executada pelo Al, contudo sua concentração média no sangue é em torno de 7 µg L -1 2-3 . A toxicidade do Al manifesta-se em pessoas com disfunção renal crônica, sendo que neste caso, os rins não conseguem eliminar o Al absorvido 4 . Essas pessoas são submetidas ao tratamento de hemodiálise, e a solução utilizada pode conter traços de Al como impureza. Dessa forma, o Al é inserido diretamente na corrente sangüínea, levando ao seu acúmulo nos ossos e no cérebro, causando doenças como a osteodistrofia renal e a encefalopatia dialítica 5 . Tendo em vista esses problemas, é necessário o controle deste elemento nas soluções de hemodiálise, através de um monitoramento periódico.A Comissão da Comunidade Européia de Toxicologia para controle de alumínio fixou em 15 µg L -1 o limite tolerável em soluções de hemodiálise 6 . Em geral, a concentração salina nessas soluções é da ordem de 400 g L -1 , o que dificulta a determinação 7 . As técnicas de detecção mais utilizadas são fluorescência de raios-X 8 , cromatografia líquida 9 , polarografia 10 , análise por ativação de nêu-trons 11 e espectrometria de absorção atômica em forno de grafite [12][13] . A espectrofotometria UV-Vis também tem sido e...

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“…With this method background correction was unnecessary for serum samples but was required for dialysis fluid analysis. Magnesium nitrate has also been used as a matrix modifier for aluminium analysis (22). T h e proposed method used oxygen at the char step to help provide better precision and smaller variation during the graphite tube life.…”

Section: E L I M I N a T I O N O F M A T R I X I N T E R F E R E N C mentioning

confidence: 99%

Methods for the Determination of Trace Aluminium Contamination in Dialysis Fluids

Woolfson

Gracey²

1988

J Clin Pharm Ther

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Summary The problems associated with aluminium contamination of dialysis fluids are reviewed. The major sources of such contamination are generally the water supply or salts used in the manufacture of the fluids. It is generally desirable to keep the aluminium concentration of the dialysate below 15 μg/l. This trace level of aluminium results in problems of analysis. Literature methods, notably atomic absorption spectroscopy with electrothermal atomization, neutron activation analysis and inductively coupled plasma atomic emission spectroscopy are considered. Results from these methods are not always in agreement. It is concluded that graphite furnace atomic absorption spectroscopy (GF‐AAS) is the most suitable technique. However, it is necessary to consider the effect of matrix interferences, notably chloride, on the determination of aluminium in dialysis fluids by this method. Reliable results for trace aluminium determinations by GF‐AAS can be obtained using a suitable furnace programme together with matrix adjusters such as nitric or orthophosphoric acids.

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Evaluation of the L'vov platform and matrix modification for the determination of aluminium in serum

Cited by 41 publications

References 0 publications

Determination of antimony, arsenic, bismuth and copper by inductively coupled plasma atomic emission spectrometry in the electrorefining of copper

Determination of antimony, arsenic, bismuth and copper by inductively coupled plasma atomic emission spectrometry in the electrorefining of copper

Determinação espectrofotométrica de alumínio em concentrados salinos utilizados em hemodiálise empregando pré-concentração em fluxo

Methods for the Determination of Trace Aluminium Contamination in Dialysis Fluids

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