Evaluation of the Inhibitory Activities of the Extracts of Indonesian Traditional Medicinal Plants against Plasmodium falciparum and Babesia gibsoni

Murnigsih, Tri; subeki, subeki; Matsuura, Hideyuki; Takahashi, Kosaku; Yamasaki, Masahiro; Yamato, Osamu; Maede, Yoshimitsu; Katakura, Ken; Suzuki, Mamoru; Kobayashi, Shogo; Chairul,; Yoshihara, Toshio

doi:10.1292/jvms.67.829

Cited by 62 publications

(50 citation statements)

References 11 publications

(13 reference statements)

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“…; García Barriga 1975. ) The species was also dispersed to the Pacific, and is now used as an antimalarial in Indonesia (Murnigsih et al 2005). It is also reportedly in use in South Africa and Botswana, where it is naturalized (Arnold 2002;Eloff, pers.…”

Section: Ethnobotany and History Of Usementioning

confidence: 99%

Yarrow (Achillea millefolium L.): A Neglected Panacea? A Review of Ethnobotany, Bioactivity, and Biomedical Research1

2011

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Yarrow (Achillea millefolium L.): A Neglected Panacea? A Review of Ethnobotany, Bioactivity, and Biomedical Research. Yarrow (Achillea millefolium L.) is one of the most widely used medicinal plants in the world, primarily for wounds, digestive problems, respiratory infections, and skin conditions, and secondarily, among other uses, for liver disease and as a mild sedative. Preclinical studies indicate that it may have anti-inflammatory, anti-ulcer, hepatoprotective, anxiolytic, and perhaps antipathogenic activities. Animal studies have also shown that yarrow is generally safe and well tolerated. The claim that yarrow has been shown to be specifically contraindicated during pregnancy is based on a single low-quality rat study the results of which were incorrectly interpreted. The combination of human use data from multiple cultures, independently reporting similar activities for yarrow, and the discovery of potentially relevant bioactivities by in vitro and animal studies represent meaningful evidence of the plant's efficacy. We therefore argue that human clinical trials should be funded and conducted.

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Section: Ethnobotany and History Of Usementioning

confidence: 99%

Yarrow (Achillea millefolium L.): A Neglected Panacea? A Review of Ethnobotany, Bioactivity, and Biomedical Research1

2011

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“…Plants produce phytochemicals which have protective or preventive properties against human diseases. Antimalarial activities of many medicinal plants have been reported [33][34][35] . In this study anti-malarial activity of the extract and fractions of B. ocymoides were tested using in vivo anti-plasmodial effect against chloroquinesensitive Plasmodium berghei NK 65-infected mice.…”

Section: Discussionmentioning

confidence: 99%

Antimalarial and Antioxidant Potentials of Extract and Fractions of Aerial part of Borreria ocymoides DC (Rubiaceae).

Adesegun¹,

Orabueze²,

Coker³

2017

Phcog J

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Introduction: Borreria ocymoides (Burm F) DC is a weak, erect and decumbent herb that has several folkloric, ethno medicinal uses and is included in antimalarial preparations by some traditional healers. It is also used in treatment of ring worm, eczema and microbial infections. Objectives: To evaluate antimalarial activity of extract and fractions of Borreria ocymoides in Plasmodium berghei infected mice and to investigate their antioxidant activity using 1, 1-diphenyl-2-picryl-hydrazile (DPPH). Methods: The methanol extract of aerial part of B. ocymoides and the solvent fractions obtained from partition between organic solvents were assessed for antimalarial activity against chloroquine sensitive Plasmodium berghei NK65 infected mice using the suppressive and curative test procedures. Chloroquine (10 mg/ml) was used as positive control. The antioxidant activity was evaluated using DPPH radical scavenging ability and determination of total phenolic content. Results: The crude extract (250 and 500 mg kg-1) produced a dose dependent anti-plasmodial activity in the suppressive and curative tests. The chemo suppression activity was best in the ethyl acetate fraction (87.31%) and in the order ethyl acetate >dichloromethane > hexane > aqueous fraction. The DPPH radical scavenging activity of the extract increased with concentration. The antioxidant activity was less than ascorbic acid used as positive control. Oral administration up to 5 g/kg produced no noticeable deleterious effect 24 hours after dosing and up to 7 days afterwards. Conclusion:The results indicated that the extract has a potent anti-plasmodial activity against Plasmodium berghei and the activity seems to reside in the mid-polar fractions. Thus, the plant is a potential source of new antimalarial agents.

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“…So far, the antibacterial activity of S. lucida has not been reported in literature. However, the extracts of S. lucida had been documented to exhibit strong antimalarial activity against Plasmodium falciparum and Babesia gibsoni (Murnigsih et al, 2005). Other Strychnos species have however been shown to display antimicrobial activity.…”

Section: Discussionmentioning

confidence: 99%

Antimicrobial, antioxidant and anticancer activities of <i>Strychnos lucida</i> R. Br.

Sarmento¹,

Worachartcheewan²,

Pingaew³

et al. 2015

Afr. J. Trad. Compl. Alt. Med.

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Backgroud: Strychnos lucida R. Br. (Loganiaceae), a well-known indigenous medicine in Timor Leste, has been used for the treatment of ailments such as malaria, diarrhoea, fever, hypertension, cancer, diabetes mellitus and skin infections. Its pharmacological activity has never been reported. The aim of this study was to determine the biological activities of S. lucida, including antimicrobial, antioxidant and anticancer activities. Materials and methods:The stem, stem bark, twig and leaves of S. lucida were extracted by non-polar (hexane) and polar (ethyl acetate and methanol) solvents. Antimicrobial activity of the plant extracts against 29 microorganisms was evaluated using the agar dilution method and antioxidant properties were determined using DPPH and SOD assays. Anticancer activity was investigated against HepG2, HuCCA-1, A549 and MOLT-3 cell lines using the MTT and XTT assays. Results: It was found that the hexane and ethyl acetate extracts of S. lucida selectively inhibited the growth of Gram positive bacteria (Bacillus subtilis ATCC 6633, Bacillus cereus and Streptococcus pyogenes) with MICs range of 32-128 g/mL. Antioxidant activities, radical and superoxide scavenging properties, were observed for ethyl acetate and methanol extracts of S. lucida. Particularly, the ethyl acetate extracts selectively showed inhibitory activity against MOLT-3 cells. Notably, the plant extracts showed the relationship between antimicrobial, antioxidant and anticancer activities. Conclusion:The findings support the medicinal usage of S. lucida.

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Evaluation of the Inhibitory Activities of the Extracts of Indonesian Traditional Medicinal Plants against Plasmodium falciparum and Babesia gibsoni

Cited by 62 publications

References 11 publications

Yarrow (Achillea millefolium L.): A Neglected Panacea? A Review of Ethnobotany, Bioactivity, and Biomedical Research1

Yarrow (Achillea millefolium L.): A Neglected Panacea? A Review of Ethnobotany, Bioactivity, and Biomedical Research1

Antimalarial and Antioxidant Potentials of Extract and Fractions of Aerial part of Borreria ocymoides DC (Rubiaceae).

Antimicrobial, antioxidant and anticancer activities of <i>Strychnos lucida</i> R. Br.

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