Evaluation of the influence of metabolic processes and body composition on cognitive functions: Nutrition and Dementia Project (NutrDem Project)

Magierski, Radosław; Kłoszewska, Iwona; Sobów, Tomasz

doi:10.1038/ejcn.2014.171

Cited by 5 publications

(2 citation statements)

References 38 publications

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“… 36 Kobayashi et al 37 found that diastolic blood pressure is an independent risk factor affecting the extent of decreased regional cerebral blood flow and is considered an indicator of cognitive impairment. 38 In general, hypertension does not exist alone; it is always accompanied by other risk factors, such as metabolic risks 39 , 40 or stroke-related factors. 41 , 42 Future research should focus on the interaction of multiple risk factors with a longer follow-up period.…”

Section: Discussionmentioning

confidence: 99%

The association between the prevalence, treatment and control of hypertension and the risk of mild cognitive impairment in an elderly urban population in China

Jiang

et al. 2016

Hypertens Res

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It remains unclear whether lowering the blood pressure effectively prevents cognitive impairment. The aim of the current study was to explore the association between the prevalence, treatment and control of hypertension and the risk of mild cognitive impairment (MCI) among elderly Chinese people. This is a cross-sectional study conducted in Beijing, China. A two-stage stratified clustering sampling method was used, and 2065 participants, aged ⩾60 years, were included in the analysis. The Mini-Mental State Examination was used to assess participants' cognitive function. The prevalence of MCI was higher in hypertensive (16.5%) than in normotensive individuals (13.1% P=0.043). Furthermore, in those hypertensive patients, the prevalence of MCI was lower in those treated (14.9%) than in those not treated (19.9% P=0.019) and lower in those controlled (13.4%) than in those uncontrolled (17.9% P=0.042). The adjusted odds ratio (OR; 95% confidence interval (CI)) of having MCI was 1.59 (1.07–2.35) in those with hypertension compared with those normotensive individuals. The assessment of the hypertensive patients revealed the adjusted OR (95% CI) of having MCI in those with treated hypertension was 0.60 (0.42–0.86) compared with those untreated hypertension, and in those with controlled hypertension was 0.64 (0.43–0.93) compared with those non-controlled hypertension (regardless of treatment). However, among the treated hypertensive patients, there was no difference in the prevalence of MCI between the patients who reached and those who did not reach their treatment goal. We suggest that improved diagnoses and optimal therapeutics are needed to achieve the aim of cognitive decline prevention.

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Section: Discussionmentioning

confidence: 99%

The association between the prevalence, treatment and control of hypertension and the risk of mild cognitive impairment in an elderly urban population in China

Jiang

et al. 2016

Hypertens Res

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“…impairments, amnesia, behavioral and neuropsychiatric disorders (10,11) dysphagia, side effects of pharmacotherapy (12), among others, lead to reduced dietary intake and malnutrition. Malnutrition is related to modification of many epigenetic markers, resulting in the development of complex systemic disorders such as diabetes, obesity and hypertension: all related to higher cardiovascular risk and greater progression of AD (13)(14)(15). Malnutrition increases mortality rates in adults with dementia, causes reduced muscle mass, loss of autonomy, increased falls, decubitus ulcers, systemic infections (11) and rapid cognitive decline (16).…”

Section: Nutritional Assessment In Patients With Early-onset Autosomal Dominant Alzheimer's Disease Due To Psen1-e280a Genetic Variant: Amentioning

confidence: 99%

Nutritional assessment in patients with early-onset Autosomal Dominant Alzheimer’s Disease due to PSEN1- E280A genetic variant: a cross-sectional study

Gómez-Vega¹,

García-Cifuentes²,

Aguillón³

et al. 2021

J Aging Res & Lifestyle

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Background: Weight loss and malnutrition are frequent findings in late-onset and sporadic presentations of Alzheimer’s Disease (AD). However, less is known about nutritional status in Early-Onset Autosomal Dominant AD (EO-ADAD). Objective: To analyze the association between nutritional status and other clinical and sociodemographic characteristics in individuals with a genetic form of EO-ADAD. Design, settings, and participants: Cross-sectional study with 75 non-institutionalized participants from a cohort of Autosomal Dominant AD (13 with mild cognitive impairment and 61 with dementia, ages from 38 to 67 years) underwent a structured clinical assessment with emphasis on nutritional status. Measurements: Primary outcome was nutritional status and it was measured using the Mini Nutritional Assessment (MNA). Patients were categorized according to MNA total score, as undernourished (MNA ≤23.5) and well-nourished (MNA ≥ 24). Sociodemographic and clinical variables identified as potential predictors or confounders of nutritional status were also collected. Results: Undernourishment by MNA was present in 57.3% of the sample. Forty-two percent of participants had abnormal BMI values considered lower than 18.5 or higher than 24.9 kg/m2. Total BMI values were similar in well and undernourished patients (median 24.2 IQR 3.59 and median 23.9 IQR 4.42, respectively, p=0.476). When comparing well and undernourished groups, we found statistically significant differences for variables: severity of dementia (p=0.034), frailty (p=0.001), multimorbidity (p=0.035) and, polymedication (p=0.045). Neither adjusted logistic regression nor the Poisson regression showed that any clinical or sociodemographic variables explained undernourishment. Conclusions: Undernourishment was a frequent finding in our sample of EO-ADAD, especially in later stages of the disease. Patients with polymedication, multimorbidity, frailty and severe dementia show differences in their nutritional status with a tendency to be more frequently undernourished. Further studies with larger sample sizes are needed to establish this association.

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Changes of nutritional habits in patients with Alzheimer's disease

Ciszewska-Czarnecka¹,

Kłoszewska

2016

Postępy Psychiatrii i Neurologii

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Evaluation of the influence of metabolic processes and body composition on cognitive functions: Nutrition and Dementia Project (NutrDem Project)

Cited by 5 publications

References 38 publications

The association between the prevalence, treatment and control of hypertension and the risk of mild cognitive impairment in an elderly urban population in China

The association between the prevalence, treatment and control of hypertension and the risk of mild cognitive impairment in an elderly urban population in China

Nutritional assessment in patients with early-onset Autosomal Dominant Alzheimer’s Disease due to PSEN1- E280A genetic variant: a cross-sectional study

Changes of nutritional habits in patients with Alzheimer's disease

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