Changes of nutritional habits in patients with Alzheimer's disease

Ciszewska-Czarnecka, Katarzyna; Kłoszewska, Iwona

doi:10.1016/j.pin.2016.02.001

Cited by 2 publications

(2 citation statements)

References 41 publications

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“…While obesity is an unquestioned risk factor for VaD, as confirmed here by BMI being an independent predictor of VaD, the association between BMI and AD remains controversial 43 . Nonetheless, dementia is frequently accompanied by a change of nutritional habits and weight loss as well as nutritional deficits are common in dementia and parallel the severity of cognitive impairment 44 . Our patients, however, were well nourished as indicated by BMI, slightly elevated, and relatively high MNA score, similar in all patients.…”

Section: Discussionmentioning

confidence: 99%

Targeted metabolomic analysis of nitric oxide/L-arginine pathway metabolites in dementia: association with pathology, severity, and structural brain changes

Fleszar

Wiśniewski

Zboch

et al. 2019

Sci Rep

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L-Arginine/NO pathway is altered in Alzheimer disease (AD). Its clinical relevance and pathway status in vascular dementia (VaD) are unknown. Using targeted metabolomics (a liquid chromatography-mass spectrometry) we assessed L-arginine, L-citrulline, dimethylamine (DMA), asymmetric dimethyl arginine (ADMA) and symmetric dimethylarginine (SDMA) in AD (n = 48), mixed-type dementia (MD; n = 34), VaD (n = 40) and non-demented individuals (n = 140) and determined their clinical relevance (the association with dementia pathology, cognitive impairment, and structural brain damage). L-Arginine, ADMA, L-arginine/ADMA, and L-citrulline levels were decreased in dementia and L-arginine, L-citrulline, age and sex were its independent predictors correctly classifying 91% of cases. L-Arginine and L-arginine/ADMA were differentiating between VaD and AD with moderate accuracy. L-Arginine, L-arginine/ADMA, SDMA, and DMA reflected structural brain changes. DMA and L-citrulline were elevated in patients with strategic infarcts and SDMA, L-arginine/ADMA, and DMA were independent predictors of Hachinski ischemic score. ADMA and SDMA accumulation reflected severity of cognitive impairment. In summary, L-Arginine/NO pathway is altered in neurodegenerative and vascular dementia in association with neurodegenerative and vascular markers of brain damage and severity of cognitive impairment.

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Section: Discussionmentioning

confidence: 99%

Targeted metabolomic analysis of nitric oxide/L-arginine pathway metabolites in dementia: association with pathology, severity, and structural brain changes

Fleszar

Wiśniewski

Zboch

et al. 2019

Sci Rep

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“…Some studies have correlated dysphagia to the individual's general nutritional status. For instance, studies [28][29][30][31][32][33][34] found the correlations between nutritional aspects and dysphagia. Ultimately, the studies converge on the following results: the more severe the dysphagia, the worse the individual's nutritional condition.…”

Section: Dysphagia Characteristics and Symptom Progressionmentioning

confidence: 99%

Dysphagia in Alzheimer’s disease: a systematic review

Mira

Gonçalves

Rodrigues

2022

Dement. neuropsychol.

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Dysphagia is described as a highly relevant comorbidity of Alzheimer’s disease (AD). However, there is a scarcity of studies aiming at the characteristics and progression of dysphagia. Objective: The objective of this study was to identify the specific characteristics, progression, and prevalence of dysphagia in AD. Methods: Publications were searched in the PubMed (MEDLINE), EBSCO, ScienceDirect, and BASE databases. Critical appraisal and evidence-level analysis were conducted using the Joanna Briggs Institute and Effective Public Health Practice Project’s (EPHPP) tools. Results: A total of 26 studies were reviewed. Symptoms begin in the early stage of AD, as oral phase impairments, and progress to pharyngeal symptoms and swallowing apraxia in the later stages of AD. Dysphagia progresses, as AD, along a continuum, with severity depending on individual variability. There were no studies found on prevalence. Conclusions: Dysphagia is a complex and important comorbidity in AD that impacts the quality of life. No recent publications on prevalence may imply that is not being coded as a potential cause for pneumonia deaths in AD.

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Changes of nutritional habits in patients with Alzheimer's disease

Cited by 2 publications

References 41 publications

Targeted metabolomic analysis of nitric oxide/L-arginine pathway metabolites in dementia: association with pathology, severity, and structural brain changes

Targeted metabolomic analysis of nitric oxide/L-arginine pathway metabolites in dementia: association with pathology, severity, and structural brain changes

Dysphagia in Alzheimer’s disease: a systematic review

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