Evaluation of the impact of orally administered carbohydrates on postprandial blood glucose levels in different pre-clinical models

Marques, Any de Castro Ruiz; Schiavon, Fabiana Percinoto Monteiro; Travassos, Patrícia Batista; Eik, Vanessa Fontana; Godoy, Guilherme; Schamber, Christiano Rodrigues; Bazotte, Roberto Barbosa

doi:10.1590/s1984-82502016000400021

Cited by 3 publications

(1 citation statement)

References 36 publications

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“…Mice were divided into 8 groups (n = 3-4 per group) which were given increasing ip doses of insulin: (0.5, 1.0, 1.5, 2.0, 3.0, 4.0, 5.0, or 10.0 U/kg). Blood samples were collected from the tail at 0, 30, 60, 90, and 120 min after insulin injection, as previously described (Marques et al, 2016). Glycemia (mmol/L) was evaluated with a home glucometer (Optium Xceed®, Abbott Laboratories, Chicago, IL, USA), which is known to show good accuracy compared with the gold standard method used to measure plasma glucose (Robinson, Sharp, 2012).…”

Section: Dose Response Curve and Seizuresmentioning

confidence: 99%

Oral lactate intensifies insulin toxicity during severe insulin-induced hypoglycemia in mice

Vilela

Antunes

Godoi

et al. 2018

Braz. J. Pharm. Sci.

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We investigated whether oral lactate could prevent seizures and deaths in mice with severe hypoglycemia induced by a high dose of insulin. For this purpose, mice were fasted for 15 h and then given an intraperitoneal injection of regular insulin (5.0 U/kg or 10.0 U/kg). Immediately after insulin injection, the mice received an oral dose of saline (control), glucose (5.5 mmol/kg), or lactate (18.0 mmol/kg). Glucose and lactate levels were measured in the blood and brain before and after the seizures began. Glucose and lactate delayed (p < 0.05) the onset of seizures associated with severe insulin-induced hypoglycemia. Elevated (p < 0.05) brain levels of lactate were associated with an absence of seizures in mice that received glucose or lactate, suggesting that lactate could prevent convulsions associated with severe insulin-induced hypoglycemia. However, the same oral dose of lactate that delayed the onset of convulsions also increased the mortality rate. In contrast, diazepam (3.0 mg/kg) prevented seizures and markedly decreased the frequency of death during severe insulin-induced hypoglycemia. The results demonstrated that in contrast to oral glucose, oral lactate intensifies insulin toxicity.

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Section: Dose Response Curve and Seizuresmentioning

confidence: 99%

Oral lactate intensifies insulin toxicity during severe insulin-induced hypoglycemia in mice

Vilela

Antunes

Godoi

et al. 2018

Braz. J. Pharm. Sci.

Self Cite

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Determining the glycaemic responses of foods: conventional and emerging approaches

2021

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A low-glycemic diet is crucial for those with diabetes and cardiovascular diseases. Information on the glycemic index (GI) of different ingredients can help in designing novel food products for such target groups. This is because of the intricate dependency of material source, composition, food structure, and processing conditions, among other factors, on the glycemic responses. Different approaches have been used to predict the GI of foods, certain discrepancies exist because of factors including the inter-individual variation among human subjects. Besides other aspects, it is important to understand the mechanism of food digestion because an approach to predict GI must essentially mimic the complex processes in the human gastrointestinal tract. The focus of this work is to review the advances in various approaches for predicting the glycemic responses of foods. This has been explained by detailing conventional approaches, their merits and limitations, and the need to focus on emerging approaches. Given the fact that no single approach can be generalized for all applications, the review emphasizes the scope of deriving insights for improvements in methodologies. Reviewing the conventional and emerging approaches for the determination of GI in foods, this detailed work is intended to serve as a state-of-the-art resource for food and nutritionists who work on developing low GI foods.

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Glycerol Potentiates the Effects of Glucose in Promoting Glucose Recovery During Hypoglycemia: From Basic to Clinical Investigations and Their Therapeutic Application

Filho

Ferrari

Antunes

et al. 2021

Journal of Medicinal Food

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Evaluation of the impact of orally administered carbohydrates on postprandial blood glucose levels in different pre-clinical models

Cited by 3 publications

References 36 publications

Oral lactate intensifies insulin toxicity during severe insulin-induced hypoglycemia in mice

Oral lactate intensifies insulin toxicity during severe insulin-induced hypoglycemia in mice

Determining the glycaemic responses of foods: conventional and emerging approaches

Glycerol Potentiates the Effects of Glucose in Promoting Glucose Recovery During Hypoglycemia: From Basic to Clinical Investigations and Their Therapeutic Application

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