Evaluation of the impact of computed high b-value diffusion-weighted imaging on prostate cancer detection

Abstract

High b-value cDWI using ME, IVIM, and SE diffusion models provide better image quality, lesion conspicuity, and increased LBCR than high b-value aDWI. Using cDWI can potentially provide comparable sensitivity and specificity for detecting significant PCa as high b-value aDWI without increased scan times and image degradation artifacts.

Computed Diffusion-Weighted Imaging in Prostate Cancer: Basics, Advantages, Cautions, and Future Prospects

“…The mono-exponential model is simpler to perform, and evidence indicates that it performs as well or almost as well as the bi-exponential model for computed DWI ( 30 ). The study performed by Verma et al ( 31 ) showed that high b-value (2000 s/mm 2 ) computed DWI using mono-exponential model, intra-voxel incoherent motion model, and stretched exponential diffusion model provided better image quality and lesion conspicuity, and increased lesion-to-background contrast ratios, as compared with acquired DWI. However, there were no significant differences in the detectability of prostate cancer among the computed DWIs and acquired DWI.…”

Comparison of the Diagnostic Performance of Synthetic Versus Acquired High b‐Value (1500 s/mm2) Diffusion‐Weighted MRI in Women With Breast Cancers

“…However, their study included only single breast cancer patients, and there was no direct comparison between the same b values of computed and acquired DWIs. Recently, two studies that directly compared acquired and synthetic high b‐value DWI in prostate cancer patients reported that synthetic high b‐value DWI yielded a higher lesion detection rate, better image quality, higher lesion conspicuity, and increased lesion‐to‐background contrast ratios . However, prostate MRI has a significantly smaller field of view, and prostate gland background tissue is relatively more homogeneous than that of the breast.…”

“…This result is consistent with those of previous studies comparing the diagnostic accuracy of synthetic and acquired high b-value DWI. Blackledge et al 29 31,32 However, prostate MRI has a significantly smaller field of view, and prostate gland background tissue is relatively more homogeneous than that of the breast. Moreover, the prostate gland is less prone to motion artifact.…”

“…Previous studies have reported that a synthetic high b-value DWI is feasible with good SNR, and results in less image distortion, which leads to improved lesion detection in patients with metastatic disease involving bone and soft tissues, primary prostate cancers, and breast cancers. [29][30][31][32][33][34] Thus, the present study aimed to compare the diagnostic performances of synthetic b = 1500 s/mm 2 (S-b1500) and acquired b = 1500 s/mm 2 (A-b1500) DWI in women with known breast cancers.…”

Evaluation of Exponential ADC (eADC) and Computed DWI (cDWI) for the Detection of Prostate Cancer

“…cDWI images compared to original DWI images at the same b-value featured a reduced artifact level with similar or better CR and CNR values without additional acquisition time on top of the scan time used to obtain DWI with standard b-values [10,12,15,17,21].…”