Evaluation of the impact of anaemia on quality of life among breast cancer patients undergoing chemotherapy in Malaysia

Muthanna, Fares Mohammed Saeed; Hassan, Bassam Abdul Rasool; Karuppannan, Mahmathi; Mohammed, Ali Haider

doi:10.1093/jphsr/rmaa033

Cited by 7 publications

(5 citation statements)

References 7 publications

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“…Anemia is a frequent complication in critically ill and cancer patients. It has been linked to a reduction in quality of life as well as a poor prognosis [ 4 ]. In addition, sadness, frustration, and exhaustion can all contribute to a patient's feeling that life is pointless because of the lowered quality of life associated with anemia [ 23 ].…”

Section: Discussionmentioning

confidence: 99%

“…Anemia is common in cancer patients, with incidence rates ranging from 22.7% [ 1 ] to 63% [ 2 ] and increasing to 89% following chemotherapy [ 3 ]. Increase incidence of anemia has been associated with reduced treatment response and quality of life of breast cancer patients [ 4 , 5 ] and raises the financial burden of the disease [ 6 ]. Specific subgroups of patients are more likely to develop anemia during the course of the disease, according to Seshadri et al [ 7 ] in a 6-month follow-up survey of cancer patients.…”

Section: Introductionmentioning

confidence: 99%

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Prevalence and Associated Factors of Anemia among Breast Cancer Patients Undergoing Chemotherapy: A Prospective Study

Muthanna

Karuppannan

Abdulrahman

et al. 2022

Advances in Pharmacological and Pharmaceutical Sciences

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Purpose. The purpose of this study was to ascertain the prevalence and factors associated with anemia (hemoglobin [Hb] 12 g/dL) in breast cancer patients undergoing chemotherapy. Materials and Methods. We conducted a prospective longitudinal study to collect demographic and clinical data on adult breast cancer patients with or without anemia who were admitted to HKL, UMMC, and NCI. The incidence of anemia was determined by detecting whether or not anemia developed during the course of chemotherapy. Mild, moderate, or severe anemia was defined. A chi-squared and logistic regression model were used to assess the effect of demographic and clinical factors on the incidence of anemia and multiple logistic regression analysis was used to evaluate the associations of potential risk factors with the presence of CRA. Results. The study enrolled a total of 292 breast cancer patients. Anemia occurred at a rate of 41.1% (n = 120). Our findings indicated that clinical factors such as the number of chemotherapy regimens, dose reduction, and type of chemotherapy, for example, docetaxel, as well as demographic covariates such as age and BMI, all contribute to the incidence of anemia in cancer patients. Conclusions. According to this study, the prevalence of anemia in breast cancer patients is high. Patients' age, BMI, number of chemotherapy regimens, and docetaxel were risk factors; thus, protocols are needed to identify subgroups of breast cancer likely to benefit from novel management strategies.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Prevalence and Associated Factors of Anemia among Breast Cancer Patients Undergoing Chemotherapy: A Prospective Study

Muthanna

Karuppannan

Abdulrahman

et al. 2022

Advances in Pharmacological and Pharmaceutical Sciences

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“…It has even been found that patients infected with the novel coronavirus have subsequent complications of cognitive impairment(21)(22) (23). It is thought that hypoxemia causes structural changes in the brain, or that in ammatory factors or cellular damage may play a role(24) (25). However, it may be di cult to study the mechanisms involved in breast cancer.…”

Section: Discussionmentioning

confidence: 99%

Network analysis of quality of life in older breast cancer patients: A cross-sectional research from China

Xiao

Qian

Chen

et al. 2023

Preprint

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Objective The balance between treatment effectiveness and quality of life in elderly breast cancer patients is an important issue for clinicians to consider. The purpose of this study was to investigate the quality of life of elderly breast cancer patients and to explore the most critical factors affecting the quality of life. Methods This prospective cross-sectional study was conducted in the Cancer Hospital of the Chinese Academy of Medical Sciences from June 2022 to November 2022. Frailty Screening Scale and the European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire Core 30 were assessed among breast cancer patients aged ≥65 years. Network analysis was used to identify the core symptoms in the network. Results 481 patients who met inclusion criteria were included in the final analysis. Patients were divided into early (stage I-III) and advanced (stage IV) stage groups based on AJCC Version 8. Patients with advanced disease had a higher incidence of frailty than those with early disease (29.5% vs 11.4%, P<0.001). The quality of life of the former was generally lower than the latter group (P < 0.05 for all three functional areas, seven single symptoms, and economic aspects). Network analysis showed that in both early and advanced stage patients, "fatigue" was the most important symptom in the network and was closely related to patients' social function, role function and physical function. It is also most directly related to global health/quality of life (gQoL). Conclusion There is a general decline in quality of life in older women with advanced breast cancer. Fatigue is the most prominent problem that affects the quality of life. Related interventions need to be considered when developing clinical care plans for these patients.

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“…Cancer-related anaemia (CRA) and fatigue are common side effects of cancer, negatively affecting patients' quality of life and prognosis. 12,13 Mild to moderate anaemia was not prioritized in cancer management until recently. 14,15 Anemia is frequently identified in advanced-stage cancer patients and can occur due to chronic inflammation caused by cancer even without antineoplastic treatment.…”

Section: Discussionmentioning

confidence: 99%

Study of anemia in non-luminal solid tumors

Dandavate,

Gadkari,

Rajbhoj

et al. 2023

Int J Adv Med

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Background: Anemia is particularly prevalent in India due to widespread malnutrition. Cancer related anemia affects about three-fourths of cancer patients, causing symptoms like fatigue, appetite loss, and difficulty concentrating, and can worsen cancer prognosis, lengthen treatment, and reduce survival rates. Anemia is a significant cause of tumor hypoxia, which exacerbates the side effects of radiotherapy and chemotherapy, and affects energy levels and emotional distress. Methods: The present cross-sectional study aims to assess the prevalence and types of anemia in patients with newly diagnosed non-luminal solid tumors. The study sample included all patients meeting the inclusion criteria, with a sample size of 100. Clinical evaluation and investigations were carried out to determine the presence and severity of anemia. Data was compiled and analyzed. Results: Of the 100 patients enrolled, 68% had evidence of anemia, and the majority of them were in the age group of 51-60 years. Anemia’s association with body mass index (BMI) was noted and was more common in underweight and normal-weight patients. The commonest malignancies in the study were head and neck cancers, breast cancers and female genital cancers, and the incidence of anemia in these malignancies was higher than in other tumors. When sub-classified a higher prevalence in gynecological tumors was noted. The majority of anemic patients had mild anemia, with microcytic hypochromic anemia being the most common type. Conclusions: The study provides valuable information on the incidence and severity of anemia in patients with non-luminal solid tumors, which can help clinicians in their treatment planning and management.

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Evaluation of the impact of anaemia on quality of life among breast cancer patients undergoing chemotherapy in Malaysia

Cited by 7 publications

References 7 publications

Prevalence and Associated Factors of Anemia among Breast Cancer Patients Undergoing Chemotherapy: A Prospective Study

Prevalence and Associated Factors of Anemia among Breast Cancer Patients Undergoing Chemotherapy: A Prospective Study

Network analysis of quality of life in older breast cancer patients: A cross-sectional research from China

Study of anemia in non-luminal solid tumors

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