Evaluation of the efficiency and safety of and adherence to an optimized antimicrobial therapy regimen for pelvic inflammatory diseases

Сарвилина, И. В.; Kasabova, N.; Rybinskaya, N.; Paranuk, M.; Topchiy, A.; Babayan, Bella; Tuisk, L.; Baburina, E

doi:10.29296/25877305-2019-10-11

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“…В итоге 9 оригинальных исследований было включено в настоящий метаанализ (табл. 1) [16][17][18][19][20][21][22][23][24].…”

Section: результатыunclassified

“…Характеристика отобранных исследований. В итоговый анализ было включено 9 исследований (1409 пациентов: 700 -в группах с МК, 709 -в группах сравнения), выполненных в Италии (n=1) [16] и России (n=8) [17][18][19][20][21][22][23][24]. Пять работ было проведено на популяции H. pylori-инфицированных пациентов с использованием амоксициллина и кларитромицина (длительностью 7-14 дней) [16,17,19,20,24], в 3 работах назначалась АБТ пациенткам с воспалительными заболеваниями органов малого таза (длительностью от 10 дней) [21][22][23], в 1 работе назначался доксициклин для терапии пациентов с акне (длительностью 8 нед) [18].…”

Section: результатыunclassified

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Effect of adjuvant therapy with butyric acid on the safety profile of oral antibiotic therapy: a meta-analysis of controlled studies

Андреев¹,

Kucheryavy²,

Казюлин³

et al. 2021

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Aim. Systematization of data on the effect of adjuvant therapy with butyric acid (BA) on the safety profile of oral antibiotic therapy (ABT). Methods. Search of studies were carried out in MEDLINE/PubMed, EMBASE, Cochrane, Google Scholar, Russian Science Citation Index (RSCI) electronic databases until April 2021 inclusive. We analyzed titles and annotations in the named databases. The following combination of keywords was used for the search: "butyric acid" or "butyrate" + "antibiotic therapy" or "antibiotics" or "eradication" or "eradication therapy", as well as their analogs in English for searching in foreign databases. Results. The meta-analysis included 9 controlled studies (1 – Italy, 8 – Russia) involving 1409 patients (700 – in groups with BA; 709 – in comparison groups). Meta-analysis showed that the addition of BA to ABT regimens contributes to a significant reduction in the overall incidence of gastrointestinal side effects (odds ratio – OR 0.424, 95% confidence interval – CI 0.218–0.824), the incidence of diarrhea during the 1st (OR 0.228 , 95% CI 0.103–0.507) and 2nd week (OR 0.141, 95% CI 0.0732–0.271), abdominal distention during 1st (OR 0.392, 95% CI 0.180–0.854) and 2nd week ( OR 0.136, 95% CI 0.0480–0.384), bitterness in the mouth during 2nd week (OR 0.284, 95% CI 0.115–0.700). Conclusion. A meta-analysis has shown that the inclusion of BA in ABT regimens significantly reduces the incidence of side effects (diarrhea, bloating, bitterness in the mouth).

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“…В итоге 9 оригинальных исследований было включено в настоящий метаанализ (табл. 1) [16][17][18][19][20][21][22][23][24].…”

Section: результатыunclassified

Effect of adjuvant therapy with butyric acid on the safety profile of oral antibiotic therapy: a meta-analysis of controlled studies

Андреев¹,

Kucheryavy²,

Казюлин³

et al. 2021

View full text Add to dashboard Cite

show abstract

Evaluation of the efficiency and safety of and adherence to an optimized antimicrobial therapy regimen for pelvic inflammatory diseases

Cited by 1 publication

References 0 publications

Effect of adjuvant therapy with butyric acid on the safety profile of oral antibiotic therapy: a meta-analysis of controlled studies

Effect of adjuvant therapy with butyric acid on the safety profile of oral antibiotic therapy: a meta-analysis of controlled studies

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