Evaluation of the efficacy of two potassium nitrate bioadhesive gels (5% and 10%) in the treatment of dentine hypersensitivity. A randomised clinical trial

Frechoso, Susana Cuesta; Menéndez, Manuel; Guisasola, Cristina; Arregui, Ignacio; Tejerina, José María Rodríguez; Sicilia, Alberto

doi:10.1034/j.1600-051x.2003.20077.x

Cited by 50 publications

(46 citation statements)

References 16 publications

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“…Chemical agents that have been suggested included strontium chloride, sodium fluoride, formalin solution 9) , ferric oxalate 10) , calcium hydroxide, stannous hydroxide, calcium oxalate, ferric phosphate 11) , potassium nitrate 12) , visible light-cured materials 13) , and fluoride varnishes 14) , while physical agents included Nd:YAG laser 15) and GaAlAs laser 16) . Although these materials yielded promising results, their therapeutic effects were relatively short-lived or decreased with time because these agents could be gradually removed by daily toothbrushing or acidic beverage drinking.…”

Section: Introductionmentioning

confidence: 99%

In Vitro Study of Dentinal Tubule Occlusion with Sol-gel DP-bioglass for Treatment of Dentin Hypersensitivity

et al. 2007

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DP-bioglass paste has been demonstrated to produce 60 μm of sealing depth on exposed dentinal tubules. However, the occlusive effect depended on a continuous placement of DP-bioglass paste on dentinal surface for three days. In a bid to fabricate highly reactive DP-bioglass particles, a sol-gel method was used together with HNO3, NaOH, and H3PO4 as catalysts. As a result, the application time of DP-bioglass paste was significantly reduced to 10 minutes. Percentage of tubular occlusion with DP-bioglass was 53.2-65.4％, while One Coat Bond and Seal & Protect yielded 51.3％ and 41.2％ respectively. Further, the average depth of tubular occlusion with DP-bioglass was 55.8-62.7 μm, while One Coat Bond and Seal & Protect produced 40.8 μm and 32.5 μm respectively. In conclusion, the best sealing performance of tubular occlusion was rendered by DP-bioglass catalyzed with HNO3. Its performance was significantly better than Seal & Protect, and was considered to exhibit the greatest potential in treating dentin hypersensitivity.

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Section: Introductionmentioning

confidence: 99%

In Vitro Study of Dentinal Tubule Occlusion with Sol-gel DP-bioglass for Treatment of Dentin Hypersensitivity

et al. 2007

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“…A clinical study using 5% potassium nitrate solution also found no DH reduction 13) . However, a study using 10% potassium nitrate gel reported a 35% reduction in DH within 48-96 h 14) and another study using 35% potassium nitrate gel reported a 91% reduction in DH immediately after application 15) . A wide range of agents have been shown to relieve DH by occluding the dentinal tubules, thus reducing stimulus-evoked fluid flow 10) .…”

Section: Introductionmentioning

confidence: 99%

The synthesis and characterization of a novel potassium chloride-fluoridated hydroxyapatite varnish for treating dentin hypersensitivity

Lochaiwatana

Poolthong

Hirata

et al. 2015

Dental Materials Journal

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Dentin hypersensitivity is treated using materials that occlude the dentinal tubules or release potassium ions that induce nerve desensitization. In this study we formulated a novel varnish containing potassium chloride and fluoridated hydroxyapatite and evaluated its physical properties and cytotoxicity. Potassium ion release from the varnish was measured. Dentin permeability was evaluated by measuring the hydraulic conductance of etched dentin discs treated with the varnish. The direct contact test and MTT assay were performed to evaluate the varnish's cytotoxicity. We found that the varnish released potassium ions over 6 h, and demonstrated a statistically higher reduction in dentin permeability compared to commercial fluoride varnish or control. Dentin disc scanning electron microscopy images demonstrated occluded dentinal tubules in the novel varnish group after brushing. The cytotoxicity tests indicated the varnish was biocompatible with gingival and pulpal fibroblasts. We propose the novel varnish is a potential material for use in hypersensitivity management.

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“…Subjects who had undertaken treatment with any product that could influence the DH of the patient in the 30 days prior to baseline were excluded. 26 In addition, subjects were also excluded if they were allergic to ingredients used in the study or exhibited any gross oral pathology, eating disorders, chronic disease, pregnancy and lactation, acute myocardial infarction within the past six months, use of pacemaker, uncontrolled metabolic disease, major psychiatric disorder, heavy smoking or alcohol abuse, any systemic disease or any disease requiring repeated or regular analgesia, anti-inflammatory drugs, or antihistamines. 25 …”

Section: Inclusion-exclusion Criteriamentioning

confidence: 99%

Clinical efficacy of a herbal dentifrice on dentinal hypersensitivity: a randomized controlled clinical trial

et al. 2013

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Background: Dentinal hypersensitivity is a common problem and there is a growing interest in herbal based formulations for the treatment of oral diseases. This study was conducted to assess the efficacy of a commercially available novel herbal dentifrice in reduction of dentinal hypersensitivity. Methods: A total of 73 subjects (38 males and 35 females; aged 25-60 years) were randomly divided into two groups: Group 1 -a placebo dentifrice (The Himalaya Drug Company Research and Development, Makali, Bangalore) and Group 2 -(test group), a commercially available herbal dentifrice (Hi Ora K, The Himalaya Drug Company Research and Development, Makali, Bangalore). Sensitivity scores for controlled air stimulus and cold water were recorded at baseline, 6 weeks and 12 weeks. Results: The test group was found to be significantly better compared to the placebo group at the end of 6 and 12 weeks in reduction of dentinal hypersensitivity. Conclusions: The novel herbal dentifrice can be recommended for treatment of dentinal hypersensitivity.

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Evaluation of the efficacy of two potassium nitrate bioadhesive gels (5% and 10%) in the treatment of dentine hypersensitivity. A randomised clinical trial

Cited by 50 publications

References 16 publications

In Vitro Study of Dentinal Tubule Occlusion with Sol-gel DP-bioglass for Treatment of Dentin Hypersensitivity

In Vitro Study of Dentinal Tubule Occlusion with Sol-gel DP-bioglass for Treatment of Dentin Hypersensitivity

The synthesis and characterization of a novel potassium chloride-fluoridated hydroxyapatite varnish for treating dentin hypersensitivity

Clinical efficacy of a herbal dentifrice on dentinal hypersensitivity: a randomized controlled clinical trial

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