Evaluation of the efficacy of casein phosphopeptide-amorphous calcium phosphate on remineralization of white spot lesions in vitro and clinical research: A systematic review and meta-analysis

Abstract

Background: This systematic review with meta-analyses sought to answer whether casein phosphopeptide-amorphous calcium phosphate (CPP-ACP) provided a remineralizing benefit superior to that of nonintervention or placebo. Methods: The Cochrane databases, PubMed, EmBase, and Ovid up to May 20th, 2019, were scanned, only published in English. Study information extraction and methodological quality assessments were accomplished independently by two reviewers. The “Criteria for judging risk of bias in the ‘Risk of bias’ assessment tool” was used for methodological quality assessment. The continuous data was analyzed by mean difference (MD) or standardized mean difference (SMD) with a 95% confidence interval (CI). Review Manager 5.3 was used for statistical analysis. Outcome variables include quantitative light-induced fluorescence in clinical research, average surface roughness and surface microhardness in vitro. Results: There were significant differences in the quantitative light-induced fluorescence (SMD = −0.43, 95% CI: [−0.79, −0.07], P = 0.02), average surface roughness (SMD = −8.21, 95% CI: [−10.37, −6.04], P < 0.01), Vickers microhardness (SMD = 1.19, 95% CI: [0.72, 1.66], P < 0.01), and Knoop microhardness (SMD = 3.52, 95% CI: [2.68, 4.36], P < 0.01) between the CPP-ACP and control groups or baseline. Conclusion: Within the limitations of this meta-analysis, CPP-ACP exhibited excellent remineralization effects evaluated in clinical research and in vitro, indicating outstanding restoration of form, aesthetics, and function in treating white spot lesions.

Experiences of oral health: before, during and after becoming a regular user of GC Tooth Mousse Plus ®

“…Previous clinical and laboratory studies focused on the effectiveness of TMP in preventing and reversing of early dental caries lesions (10)(11)(12)(13)(14). Meta-analyses of clinical studies have also been published to support the use of the product (11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22). However, no other study has addressed regular users' views about the product, how the product performs and addresses their individual needs (e.g.…”

“…There is a high-level of evidence supporting the ability of CPP-ACP to remineralise early caries lesions and prevent their progression (10)(11)(12)(13)(14). There are now twelve published systematic metaanalyses of these clinical studies to support the use of CPP-ACP to lower caries risk (11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22). In addition, CPP-ACP effectiveness has also been demonstrated in relation to the reduction of cariogenic bacteria and increased colonization of commensal microorganisms, and the reduction of dentine hypersensitivity (23)(24)(25)(26).…”

Effect of different surface treatments on the microhardness and colour change of artificial enamel lesions

“…Changes in mineral content as well is a determinant of deterioration of the enamel structure overtime. Therefore, indirect methods such as microhardness tests provide information on the physical property of the enamel as well as its mineral content 18 . Moreover, the conditions of the oral environment should be simulated, especially concerning the frequent alterations in the pH.…”