Evaluation of the efficacy of a new modified live porcine reproductive and respiratory syndrome virus (PRRSV) vaccine (Fostera PRRS) against heterologous PRRSV challenge

Park, Changhoon; Seo, Hwi Won; Han, Kyu Young; Kang, Il Jun; Chae, Chanhee

doi:10.1016/j.vetmic.2014.05.030

Cited by 83 publications

(88 citation statements)

References 37 publications

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“…Park and co-workers found that simultaneous vaccination with two vaccines against PRRSV-1 and PRRSV-2 and single vaccination were equally effective in reducing PRRSV viremia and lung lesions following PRRSV-1 challenge whereas simultaneous vaccination had limited effect on viremia and lung lesions following challenge with PRRSV-2 [9]. This finding is in contrast to our findings and another study by the same group that showed protection against the same challenge strain in single vaccinated pigs [15]. The differences in outcome between the studies may be that Park et al used another PRRSV-2 vaccine (Fostera PRRSV), a different challenge strain and the duration between vaccination and challenge was 35 days compared to the 62 days used in the present study.…”

Section: Discussioncontrasting

confidence: 99%

Efficacy and safety of simultaneous vaccination with two modified live virus vaccines against porcine reproductive and respiratory syndrome virus types 1 and 2 in pigs

Kristensen

Kvisgaard

Pawłowski

et al. 2018

Vaccine

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Section: Discussioncontrasting

confidence: 99%

Efficacy and safety of simultaneous vaccination with two modified live virus vaccines against porcine reproductive and respiratory syndrome virus types 1 and 2 in pigs

Kristensen

Kvisgaard

Pawłowski

et al. 2018

Vaccine

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“…Real-time PCR for the vaccine virus was also performed to quantify PRRSV genomic cDNA copy (Park and others 2014a, Kim and others 2015). …”

Section: Methodsmentioning

confidence: 99%

Comparison of commercial type 1 and type 2 PRRSV vaccines against heterologous dual challenge

et al. 2016

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This study was to compare the effect of vaccination of pigs with either type 1 or type 2 porcine reproductive and respiratory syndrome virus (PRRSV) against heterologous dual challenge of both genotypes. Pigs were administered type 1 (UNISTRAIN PRRS) or type 2 (Fostera PRRS) PRRSV vaccine at 28 days of age and inoculated intranasally with both genotypes at 63 days of age. Vaccination of pigs with type 1 PRRSV was able to reduce the levels of type 1 but not type 2 PRRSV viraemia, whereas vaccination of pigs with type 2 PRRSV was able to reduce the levels of type 1 and type 2 PRRSV viraemia against a dual challenge. Vaccination of pigs with type 2 PRRSV significantly reduced lung lesions after dual challenge compared with vaccination of pigs with type 1 PRRSV. Vaccination of pigs with type 2 PRRSV induced higher numbers of type 1 and type 2 PRRSV-specific interferon-γ secreting cells compared with vaccination of pigs with type 1 PRRSV after dual challenge. The results of this study demonstrated that vaccination of pigs with type 2 PRRSV is efficacious in protecting growing pigs from respiratory disease after heterologous dual type 1 and type 2 PRRSV challenge compared with vaccination of pigs with type 1 PRRSV.

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“…First, the genetic diversity of PRRSV affected the efficacy of MLV, especially in humoral immunity, which offered better protection against antigenically homologous strains than against heterologous strains [8,17,18,22,24]. However, the protection of cellular immunity between homologous and heterologous strains was depended on the number of virusspecific interferon-c producing cells [3,22,23,33,47]. In Taiwan, three kinds of PRRSV vaccines have been used, including two MLV and one subunit vaccine.…”

Section: Discussionmentioning

confidence: 99%

Molecular epidemiology of porcine reproductive and respiratory syndrome viruses isolated from 1991 to 2013 in Taiwan

et al. 2015

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Porcine reproductive and respiratory syndrome virus (PRRSV) was first identified in Taiwan in 1991, but the genetic diversity and evolution of PRRSV has not been thoroughly investigated over the past 20 years. The aim of this study was to bridge the gap in understanding of its molecular epidemiology. A total of 31 PRRSV strains were collected and sequenced. The sequences were aligned using the MUSCLE program, and phylogenetic analysis were performed by the maximum-likelihood method and the neighbor-joining method using MEGA 5.2 software. In the early 1990s, two prototype strains, WSV and MD001 of the North American genotype, were first identified. Over the years, both viruses evolved separately. The population dynamics of PRRSV revealed that the strains of the MD001 group were predominant in Taiwan. Evolution was manifested in changes in the nsp2 and ORF5 genes. In addition, a suspected newly invading exotic strain was recovered in 2013, suggesting that international spread is still taking place and that it is affecting the population dynamics. Overall, the results provide an important basis for vaccine development for the control and prevention of PRRS.

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Evaluation of the efficacy of a new modified live porcine reproductive and respiratory syndrome virus (PRRSV) vaccine (Fostera PRRS) against heterologous PRRSV challenge

Cited by 83 publications

References 37 publications

Efficacy and safety of simultaneous vaccination with two modified live virus vaccines against porcine reproductive and respiratory syndrome virus types 1 and 2 in pigs

Efficacy and safety of simultaneous vaccination with two modified live virus vaccines against porcine reproductive and respiratory syndrome virus types 1 and 2 in pigs

Comparison of commercial type 1 and type 2 PRRSV vaccines against heterologous dual challenge

Molecular epidemiology of porcine reproductive and respiratory syndrome viruses isolated from 1991 to 2013 in Taiwan

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