Evaluation of the efficacy of lycopene gel compared with minocycline hydrochloride microspheres as an adjunct to nonsurgical periodontal treatment: A randomised clinical trial

Abstract

Background/purpose The prescription of antibiotics as an adjunct to mechanical periodontal therapy in patients with severe periodontitis is recommended; however, the side effects of antibiotics are a major concern. The aim of this study was to evaluate the efficacy of lycopene (Lyc) antioxidant gel versus minocycline hydrochloride microspheres (ARISTIN) as an adjunct to the nonsurgical treatment of periodontitis. Materials and methods Three identical periodontal pockets/patient received root surface debridement followed by the random application of either ARISTIN, Lyc, or placebo gel (control, Ctrl). Clinical parameters, plaque index, bleeding on probing, probing pocket depth, and clinical attachment loss, were recorded at the baseline and after 30 days. Additionally, the levels of interleukin-8 (IL-8), matrix metallopeptidase 9, and tissue inhibitor of metalloproteinases 1 (TIMP1) in gingival crevicular fluid samples were assessed at the same time points. Results Twenty-three patients with periodontitis completed the study. Both ARISTIN and Lyc treatments showed significantly greater gains in attachment (1.94 ± 1.33 and 1.72 ± 0.88, respectively) than the Ctrl treatment (1.04 ± 0.96). Compared with those in the Ctrl, only ARISTIN showed a significant reduction in IL-8 level, whereas TIMP1 levels were significantly upregulated in the Lyc gel and ARISTIN sites. The effect size estimation indicated that Lyc gel exhibited considerably greater efficacy than the Ctrl gel. Conclusion Lyc gel and ARISTIN offer almost equal improvement in both clinical and biochemical parameters of periodontitis.

A Comparative Analysis of Three Antioxidants in Addition to Scaling and Root Planing in Stage Three Grade B Periodontitis

“…The active component in unroasted green coffee beans that gives them their antibacterial qualities is called CGA. The antioxidant properties of this extract are linked to the presence of polyphenols, which are strong antioxidants that can neutralize free radicals by donating an electron or hydrogen atom [ 15 ]. The current research findings are dependable with those of Bharath et al, who, in their in vitro study, concluded that green coffee beans were effective against four periodontopathogenic bacteria at low concentrations.…”

The expression and clinical significance of miR-30b-3p and miR-125b-1-3p in patients with periodontitis

“…These findings were similar to a previous research to some extent, indicating patients with periodontitis showed lower level of miR-1226 in GCF than healthy controls, and a negative correlation was found between miR-1226 expression, PPD, CAL, and BOP [18]. Nonsurgical periodontal treatments, including quadrant-wise debridement, scaling and root planning, full-mouth scaling, full-mouth disinfection (FMD), FMD with adjuvant erythritol air-polishing, and drug therapies were applied in periodontitis patients, with the purpose to improve both clinical and microbiologic outcomes [38,39]. With regard to the therapeutic implications exerted by clinical significance of miR-30b-3p and miR-125b-1-3p in periodontitis, as previously reported [40], tetramethylpyrazine is a promising agent and its anti-inflammatory and anti-apoptotic effects achieved by targeting miR-302b confer a protection to periodontal ligament stem cells from injuries induced by periodontitis.…”

Classic vs. Novel Antibacterial Approaches for Eradicating Dental Biofilm as Adjunct to Periodontal Debridement: An Evidence-Based Overview

“…The use of local antibiotics as adjuncts to SD for treating deep periodontal pockets has been evaluated in many studies. Compared to SD alone, better clinical outcomes could be achieved when antibiotics are locally applied, as gel or microsphere, into pockets after SD [ 103 , 104 ]. However, no clinical benefit of using local antibiotics as adjuncts to SD was reported [ 105 ].…”