Evaluation of the efficacy of a polyherbal mouthwash containing Zingiber officinale, Rosmarinus officinalis and Calendula officinalis extracts in patients with gingivitis: A randomized double-blind placebo-controlled trial

Mahyari, Saman; Mahyari, Behnam; Emami, Seyed Ahmad; Malaekeh‐Nikouei, Bizhan; Jahanbakhsh, Seyedeh Pardis; Sahebkar, Amirhossein; Mohammadpour, Amir Hooshang

doi:10.1016/j.ctcp.2015.12.001

Cited by 47 publications

(41 citation statements)

References 39 publications

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“…e clinical effects compared between herbal mouthwashes and negative placebos were evaluated in seven RCTs [17, 18, 20-22, 24, 43] with a total of 612 participants. Eight studies [20,22,41,42,[44][45][46][47] with 287 participants evaluated the effects of herbal and CHX mouthwashes. All the included studies were carried out after the year 2000, and nine [17,18,20,22,24,[42][43][44]47] were performed after the year 2010, indicating that the popularity of the herbal mouthwashes might be growing.…”

Section: Study Characteristicsmentioning

confidence: 99%

“…Eight studies [20,22,41,42,[44][45][46][47] with 287 participants evaluated the effects of herbal and CHX mouthwashes. All the included studies were carried out after the year 2000, and nine [17,18,20,22,24,[42][43][44]47] were performed after the year 2010, indicating that the popularity of the herbal mouthwashes might be growing. Six studies [22,24,42,43,45,46] had a balanced gender ratio, and five studies [18,20,[44][45][46] excluded all the smokers in their samples.…”

Section: Study Characteristicsmentioning

confidence: 99%

“…All the included studies were carried out after the year 2000, and nine [17,18,20,22,24,[42][43][44]47] were performed after the year 2010, indicating that the popularity of the herbal mouthwashes might be growing. Six studies [22,24,42,43,45,46] had a balanced gender ratio, and five studies [18,20,[44][45][46] excluded all the smokers in their samples. e details of interventions were provided in Table 1.…”

Section: Study Characteristicsmentioning

confidence: 99%

“…Numerous herbal mouthwashes have been introduced and tested; however, the results of existing literature are inconsistent regarding the clinical effects of herbal mouthwashes on both dental plaque and gingival inflammation control compared with placebo or CHX [20][21][22], and there is a scarcity of meta-analytical evidence highlighting the overall effects of herbal mouthwashes as adjuncts to the daily self-performed oral hygiene of patients with gingivitis. Without this information, it is not possible to provide comprehensive evidence-based advice to the patients and practitioners.…”

Section: Introductionmentioning

confidence: 99%

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Effects of Herbal Mouthwashes on Plaque and Inflammation Control for Patients with Gingivitis: A Systematic Review and Meta-Analysis of Randomised Controlled Trials

Cai

Chen

Perera

et al. 2020

Evidence-Based Complementary and Alternative Medicine

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Objective. The aim of this study was to evaluate the overall effects of herbal mouthwashes as supplements to daily oral hygiene on plaque and inflammation control compared with placebos and chlorhexidine (CHX) mouthwashes in the treatment of gingivitis. Methods. PubMed, EMBASE, Cochrane Database of Systematic Reviews, Cochrane Central Register of Controlled Trials, and grey literature databases were searched. Only randomised controlled trials (RCTs) comparing herbal mouthwashes with placebos or CHX in the daily oral hygiene of patient with gingivitis were included to compare the effect of different mouthwashes on plaque and inflammation control. Results. A total of 13 studies satisfied the eligibility criteria, and 11 studies were included in meta-analyses. Significant differences were observed in favour of herbal mouthwashes compared with placebos in both plaque- and inflammation-related indices (Quigley-Hein Plaque Index, QHPI: WMD = −0.61, 95% CI (−0.80, −0.42), P<0.001; Gingival Index, GI: −0.28 (−0.51, −0.06), P=0.01; Modified Gingival Index, MGI: −0.59 (−1.08, −0.11), P=0.02; Gingival Bleeding Index, GBI: −0.06 (−0.09, −0.04), P<0.001). No significant difference was found between herbal and CHX mouthwashes. Conclusions. Herbal mouthwashes have potential benefits in plaque and inflammation control as supplements to the daily oral hygiene of patients with gingivitis. Although no difference was observed between herbal and CHX mouthwashes in the selected studies, further high-quality RCTs are needed for more firm support before advising patients with gingivitis about whether they can use herbal mouthwashes to substitute for CHX mouthwashes or not (PROSPERO registration number: CRD42019122841).

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Section: Study Characteristicsmentioning

confidence: 99%

Section: Study Characteristicsmentioning

confidence: 99%

Section: Study Characteristicsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Effects of Herbal Mouthwashes on Plaque and Inflammation Control for Patients with Gingivitis: A Systematic Review and Meta-Analysis of Randomised Controlled Trials

Cai

Chen

Perera

et al. 2020

Evidence-Based Complementary and Alternative Medicine

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“…The plant is safe when ingested as proven by other studies which uses Z. officinale Roscoe extract to treat several systemic diseases such as arthritis and gastrointestinal discomfort (Ali et al, 2008). Additionally, a combination of several herbal extracts including Z. officinale Roscoe as a mouthwash has proven to be as effective as chlorhexidine mouthwash to treat gingivitis (Mahyari et al, 2016). This has also proven that these herbal extracts have an anti-inflammatory effect on inflamed tissue whilst not causing damage to the healthy tissues.…”

Section: Discussionmentioning

confidence: 90%

The Effect of Zingiber officinale Roscoe (Ginger) on Dentin Microhardness: An in vitro Study

Zaki¹,

Baharin²,

Zaman³

et al. 2017

JAS

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It has been established that conventional root canal irrigants cause detrimental effect on the physico-chemical properties of root dentin. This study aims to determine the effect of a novel root irrigant, ginger or Zingiber officinale Roscoe essential oil on root dentin microhardness. Eighty root halves of extracted human teeth were used and prepared by embedding them individually in autopolymerizing acrylic resin. These samples were then divided into four groups (n = 20 each), i.e., i) 0.5% Z. officinale Roscoe oil, ii) 2.5% sodium hypochlorite (NaOCl, positive control), iii) 17% ethylenediaminetetraacetic acid (EDTA, positive control) and iv) normal saline (negative control). Dentin microhardness was measured using Vickers Microhardness Tester with a 50 g load and a 10-second dwell time, before and after immersion in respective solutions for 5 minutes. Measurements were taken in Vickers hardness number (VHN). All samples showed reduction in the microhardness reading; with Z. officinale Roscoe: 34.24 to 25.89, NaOCl: 31.47 to 26.34, EDTA: 33.08 to 26.04 and saline: 29.82 to 27.61 VHN. Although there was significant reduction within the Z. officinale Roscoe group (p < 0.001), the change was indifferent when compared among groups (post hoc Tukey's HSD test p > 0.05). Within the limitations of this study, Zingiber officinale Roscoe essential oil does alter dentin microhardness but to a similar extent as NaOCl and EDTA.

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Ginger in Oral Care

Ganeshpurkar¹,

Thakur²,

Jaiswal³

2020

Natural Oral Care in Dental Therapy

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Evaluation of the efficacy of a polyherbal mouthwash containing Zingiber officinale, Rosmarinus officinalis and Calendula officinalis extracts in patients with gingivitis: A randomized double-blind placebo-controlled trial

Cited by 47 publications

References 39 publications

Effects of Herbal Mouthwashes on Plaque and Inflammation Control for Patients with Gingivitis: A Systematic Review and Meta-Analysis of Randomised Controlled Trials

Effects of Herbal Mouthwashes on Plaque and Inflammation Control for Patients with Gingivitis: A Systematic Review and Meta-Analysis of Randomised Controlled Trials

The Effect of Zingiber officinale Roscoe (Ginger) on Dentin Microhardness: An in vitro Study

Ginger in Oral Care

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