Evaluation of the effects of electrical stimulation on cartilage repair in adult male rats

Zuzzi, Denise Cristina; Ciccone, Carla; Neves, Lia Mara Grosso; Mendonça, Josué Sampaio; Joazeiro, Paulo Pinto; Esquisatto, Marcelo Augusto Marretto

doi:10.1016/j.tice.2013.02.003

Cited by 23 publications

(21 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The literature has demonstrated important effects of the microcurrent in increasing the synthesis and organization of collagen fibers during the healing of different tissues, such as the skin, 9‐11 bone, 13,14 and cartilage, 15,16 although there is no detailed description of the mechanisms involved. Our data demonstrate that the microcurrent increased the expression of genes related to the synthesis and organization of collagen, such as FMDO .…”

Section: Discussionmentioning

confidence: 99%

Microcurrent and adipose‐derived stem cells modulate genes expression involved in the structural recovery of transected tendon of rats

et al. 2020

View full text Add to dashboard Cite

Tendon injuries are common and have a high incidence of re-rupture that can cause loss of functionality. Therapies with adipose-derived stem cells (ASC) and the microcurrent (low-intensity electrical stimulation) application present promising effects on the tissue repair. We analyzed the expression of genes and the participation of some molecules potentially involved in the structural recovery of the Achilles tendon of rats, in response to the application of both therapies, isolated and combined. The tendons were distributed in five groups: normal (N), transected (T), transected and ASC (C) or microcurrent (M) or with ASC, and microcurrent (MC). Microcurrent therapy was beneficial for tendon repair, as it was observed a statistically significant increase in the organization of the collagen fibers, with involvement of the TNC, CTGF, FN, FMDO, and COL3A1 genes as well as PCNA, IL-10, and TNF-α. ASC therapy significantly increased the TNC and FMDO genes expression with no changes in the molecular organization of collagen. With the association of therapies, a significant greater collagen fibers organization was observed with involvement of the FMOD gene. The therapies did not affect the expression of COL1A1, SMAD2, SMAD3, MKX, and EGR1 genes, nor did they influence the amount of collagen I and III, caspase-3, tenomodulin (Tnmd), and hydroxyproline. In conclusion, the application of the microcurrent isolated or associated with ASC increased the organization of the collagen fibers, which can result in a greater biomechanical resistance in relation to the tendons treated only with ASC. Future studies will be needed to demonstrate the biological effects of these therapies on the functional recovery of injured tendons.

show abstract

Section: Discussionmentioning

confidence: 99%

Microcurrent and adipose‐derived stem cells modulate genes expression involved in the structural recovery of transected tendon of rats

et al. 2020

View full text Add to dashboard Cite

show abstract

“…Mechanoelectrical transduction phenomena occurring naturally within the cartilage due to the FCD have prompted the development of experimental electrical stimulation protocols for therapeutic cartilage repair [ 35 , 36 ]. Therapeutic devices involving electrical stimulation are increasingly entering the clinical market [ 37 ], despite rather discouraging early results [ 38 , 39 ].…”

Section: Regenerative Approachesmentioning

confidence: 99%

Physicochemical and Biomechanical Stimuli in Cell-Based Articular Cartilage Repair

2015

View full text Add to dashboard Cite

Articular cartilage is a unique load-bearing connective tissue with a low intrinsic capacity for repair and regeneration. Its avascularity makes it relatively hypoxic and its unique extracellular matrix is enriched with cations, which increases the interstitial fluid osmolarity. Several physicochemical and biomechanical stimuli are reported to influence chondrocyte metabolism and may be utilized for regenerative medical approaches. In this review article, we summarize the most relevant stimuli and describe how ion channels may contribute to cartilage homeostasis, with special emphasis on intracellular signaling pathways. We specifically focus on the role of calcium signaling as an essential mechanotransduction component and highlight the role of phosphatase signaling in this context.

show abstract

“…Ein positiver Effekt wird bei der Mikrostrom-Behandlung der Periodontitis beschrieben [20], bei der Heilung von Sehenverletzungen [21] und Wundheilung [22]. Mikroströme unterstützen auch die Knochenheilung [23] und haben einen Einfluss auf den Knorpelstoffwechsel [24].…”

Section: Abstract ▼unclassified

Prozessmodulierte Mikrostromtherapie (ZYTOENERGESE®) im Rahmen der stationären Frührehabilitation nach Knie- bzw. Hüftoperationen

Bochdansky

Ammer

2016

Phys Med Rehab Kuror

View full text Add to dashboard Cite

Zusammenfassung Obwohl die positiven Effekte der Elektrotherapie empirisch schon seit mehreren Jahrhunderten bekannt sind, gibt es trotz neuester Forschungsergebnisse (inkl. Nobelpreis) noch immer viele offene physiologische Fragen ?ber die Wirkmechanismen, vor allem im molekular- und membranphysiologischen Bereich. Unklar ist auch, welche elektrischen Parameter f?r welche therapeutischen Ziele am optimalsten sind. In einer pragmatischen, randomisierten und plazebokontrollierten Studie wurde die zus?tzliche Effektivit?t einer neuen Form der Elektrotherapie, die prozessmodulierte Mikrostromtherapie (PMMST, Zytoenergese?), klinisch im Rahmen einer 14-t?gigen station?ren Fr?hmobilisation nach Knie- und H?ftgelenksoperationen (Totalendoprothesen) getestet. Die Ergebnisse von 114 der 120 teilnehmenden Patienten wurden ausgewertet. Ungef?hr 1 Woche postoperativ wurden bei Aufnahme, bei Entlassung und bei einer Kontrolle nach 1 Monat (=ca. 50 Tage post OP) neben klinischen Tests auch die Balancef?higkeit apparativ getestet. S?mtliche klinische Parameter zeigten eine deutliche Verbesserung am Ende des station?ren Aufenthaltes, deren Zunahme bei der Nachkontrolle geringer ausgepr?gt war als nach der Phase der Fr?hmobilisation. Nach Anwendung tats?chlicher Mikrostr?me konnte bei Patienten nach H?ftoperationen eine deutlichere Verbesserung der symmetrischen Beinbelastung als bei Patienten nach Knieoperationen festgestellt werden. Die Mechanismen, ?ber die PMMST zur Wiederherstellung der Mobilit?t von Patienten nach H?ft- oder Kniegelenksoperationen beitragen kann, bleiben vorerst unklar. Denkbar sind eine Verbesserung der Muskelfunktion und die F?rderung der Integration in den Alltagsgebrauch. Weitere Untersuchungen dazu sind gerechtfertigt, ebenso weitere Studien zur Anwendung bei der Schmerzbehandlung und Wundheilung.

show abstract

Evaluation of the effects of electrical stimulation on cartilage repair in adult male rats

Cited by 23 publications

References 20 publications

Microcurrent and adipose‐derived stem cells modulate genes expression involved in the structural recovery of transected tendon of rats

Microcurrent and adipose‐derived stem cells modulate genes expression involved in the structural recovery of transected tendon of rats

Physicochemical and Biomechanical Stimuli in Cell-Based Articular Cartilage Repair

Prozessmodulierte Mikrostromtherapie (ZYTOENERGESE®) im Rahmen der stationären Frührehabilitation nach Knie- bzw. Hüftoperationen

Contact Info

Product

Resources

About