Evaluation of the Effects of Tributiltin (TBT) on Chromosomes of the Neotropical Fish Astyanax sp. (Pisces, Tetragonopterinae)

Cipriano, Roger Raupp; Ribeiro, Ciro Alberto de Oliveira; Cestari, Marta Margarete; Fenocchio, Alberto Sérgio

doi:10.1508/cytologia.69.187

Cited by 3 publications

(1 citation statement)

References 13 publications

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“…Ferraro et al (2004), working with sub-chronic trophic contamination (13 trophic doses in a period of 60 days) at the concentration of 21 μg Pb 2+ /g in H. malabaricus, verified an increase in the frequency of nuclear alterations, chromosomal aberrations and also a significant increase of tailed nucleoids in the erythrocytes of fishes treated with Pb 2+ , showing again that extended exposures to contaminants made of lead are capable of originating damages in the genetic material of fishes. Besides, Cipriano et al (2004), studying the frequency of chromosomal aberrations in Astyanax sp (lambaris) exposed to TBT (tributyltin) at the doses of 0.3 mg/kg for 19 and 37 days, observed different chromosomal anomalies such as breakage of one or two chromatids and acentric fragments.…”

Section: Discussionmentioning

confidence: 99%

Genotoxic evaluation of different doses of inorganic lead (PbII) in Hoplias malabaricus

Ramsdorf

Ferraro

Ribeiro

et al. 2008

Environ Monit Assess

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Different genetic biomarkers have been used to evaluate the pollution effects of mutagenic agents such as metals and also a great variety of chemicals delivered on the environment by human activities. This way, the aim of the present report was to evaluate the effects of inorganic lead in fishes through the frequency of piscine micronuclei and nuclear morphological alterations in peripheral cells, chromosomal aberration frequency and comet assays in blood and kidney cells. Specimens of Hoplias malabaricus received different doses of lead by intra-peritoneal injections at time of 96 h. There was not a significant difference between control and treated groups for the piscine micronucleus and chromosomal aberration assays. In the comet assays there was a significant difference between control and contaminated groups. However, a significant difference between the applied doses was not observed. The results obtained with the comet assays also show that blood presented a higher sensibility than the kidney tissue, possibly due to the acute contamination. Although the results showed the genotoxic potential of lead at the 21 and 63 microg Pb(2 + )/g doses for both tissues, the lowest dose is considered more appropriate for future bioassays.

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Section: Discussionmentioning

confidence: 99%