Evaluation of the effects of lactose on the surface properties of alginate coated trandolapril particles prepared by a spray-drying method

Makai, Zsolt; Bajdik, János; Erös, I.; Pintye‐Hódi, Klára

doi:10.1016/j.carbpol.2008.04.029

Cited by 10 publications

(8 citation statements)

References 23 publications

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“…It is also possible to change the melting point of an active substance by spray drying, to avoid hot spots (points of spontaneous recrystallization, which appear under the high pressure in the punches) that affect the tablets' properties. Alginate–lactose coated trandolapril particles prepared by spray drying had a higher melting point and showed no differences in solubility profile relative to the parent crystals 12…”

Section: Excipients and Cospray Dried Compositesmentioning

confidence: 97%

Spray Drying Technique: II. Current Applications in Pharmaceutical Technology

Sollohub

Cal

2010

Journal of Pharmaceutical Sciences

182

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Section: Excipients and Cospray Dried Compositesmentioning

confidence: 97%

Spray Drying Technique: II. Current Applications in Pharmaceutical Technology

Sollohub

Cal

2010

Journal of Pharmaceutical Sciences

182

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“…Makai et al (2008) have evaluated the effects of lactose on the surface properties of microparticles prepared by a spray-drying method. In this work, they compared three different formulations of untreated microcrystals, alginate-based spray-dried microparticles and alginate-based lactose containing spray-dried microparticles of trandolapril.…”

Section: Effect Of Various Formulation Additives On Product Charactermentioning

confidence: 99%

Revealing facts behind spray dried solid dispersion technology used for solubility enhancement

Patel

Patel²,

Chakraborty

et al. 2015

Saudi Pharmaceutical Journal

104

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Poor solubility and bioavailability of an existing or newly synthesized drug always pose challenge in the development of efficient pharmaceutical formulation. Numerous technologies can be used to improve the solubility and among them amorphous solid dispersion based spray drying technology can be successfully useful for development of product from lab scale to commercial scale with a wide range of powder characteristics. Current review deals with the importance of spray drying technology in drug delivery, basically for solubility and bioavailability enhancement. Role of additives, selection of polymer, effect of process and formulation parameters, scale up optimization, and IVIVC have been covered to gain the interest of readers about the technology. Design of experiment (DoE) to optimize the spray drying process has been covered in the review. A lot more research work is required to evaluate spray drying as a technology for screening the right polymer for solid dispersion, especially to overcome the issue related to drug re-crystallization and to achieve a stable product both in vitro and in vivo. Based on the recent FDA recommendation, the need of the hour is also to adopt Quality by Design approach in the manufacturing process to carefully optimize the spray drying technology for its smooth transfer from lab scale to commercial scale.

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“…Another method to produce drug-loaded ALG microparticles is to use drug microcrystals as template to produce polyelectrolyte multilayers or to directly coat them with ALG [ 97 , 98 ]. In the case of multilayered systems, ALG is combined with a polycationic polymer and both layers are deposited following an alternated pattern [ 97 ].…”

Section: Alginate Applications In Oral Drug Deliverymentioning

confidence: 99%

Alginate Particles as Platform for Drug Delivery by the Oral Route: State-of-the-Art

Sosnik

2014

ISRN Pharmaceutics

129

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Pharmaceutical research and development aims to design products with ensured safety, quality, and efficacy to treat disease. To make the process more rational, coherent, efficient, and cost-effective, the field of Pharmaceutical Materials Science has emerged as the systematic study of the physicochemical properties and behavior of materials of pharmaceutical interest in relation to product performance. The oral route is the most patient preferred for drug administration. The presence of a mucus layer that covers the entire gastrointestinal tract has been exploited to expand the use of the oral route by developing a mucoadhesive drug delivery system that showed a prolonged residence time. Alginic acid and sodium and potassium alginates have emerged as one of the most extensively explored mucoadhesive biomaterials owing to very good cytocompatibility and biocompatibility, biodegradation, sol-gel transition properties, and chemical versatility that make possible further modifications to tailor their properties. The present review overviews the most relevant applications of alginate microparticles and nanoparticles for drug administration by the oral route and discusses the perspectives of this biomaterial in the future.

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Evaluation of the effects of lactose on the surface properties of alginate coated trandolapril particles prepared by a spray-drying method

Cited by 10 publications

References 23 publications

Spray Drying Technique: II. Current Applications in Pharmaceutical Technology

Spray Drying Technique: II. Current Applications in Pharmaceutical Technology

Revealing facts behind spray dried solid dispersion technology used for solubility enhancement

Alginate Particles as Platform for Drug Delivery by the Oral Route: State-of-the-Art

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