Evaluation of the effects of two doses of alpha glycerylphosphorylcholine on physical and psychomotor performance

Abstract

BackgroundRecent studies have suggested that alpha glycerylphosphorylcholine (A-GPC) may be an effective ergogenic aid. The present study was designed to assess the efficacy of two doses of A-GPC in comparison to placebo and caffeine for increasing countermovement jump performance, isometric strength, and psychomotor function.MethodsForty-eight healthy, college aged males volunteered for the present study and underwent baseline assessment of countermovement jump (CMJ), isometric mid thigh pull (IMTP), upper body isometric strength test (UBIST), and psychomotor vigilance (PVT). Following this assessment participants were randomly assigned to groups consisting of 500 mg A-GPC, 250 mg A-GPC, 200 mg Caffeine or Placebo taken daily. Blood samples were collected 1 h and 2 h post initial dose to quantify serum free choline and thyroid stimulating hormone then subjects returned after 7 days of supplementation to repeat CMJ, IMTP, UBIST and PVT.ResultsNo differences were noted between groups for IMTP, UBIST or PVT performance. Serum free choline was found to be elevated in the two A-GPC groups as compared to placebo (132% and 59% respectively). Serum TSH was found to be significantly depressed in the 500 mg A-GPC group compared to other treatments (p < 0.04). Group differences were noted for maximum velocity and maximum mechanical power on the CMJ (p < 0.05) with the 250 mg A-GPC group demonstrating the greatest improvements in result.ConclusionsBased upon this evidence, and previous evidence regarding A-GPC, it should be considered as an emerging ergogenic supplement.

Effects of two pre-workout supplements on concentric and eccentric force production during lower body resistance exercise in males and females: a counterbalanced, double-blind, placebo-controlled trial

“…This compound has been reported to increase nitric oxide production [ 16 , 17 ] and may decrease fatigue during exercise [ 18 , 19 ], as well as increase training volume during resistance training [ 19 ]. Other ingredients with varying degrees of performance-enhancing potential (creatine [ 20 ], betaine [ 21 , 22 ], alpha-glyceryl phosphoryl choline [ 23 , 24 ] and huperzine A) were also present in both supplements. A number of specific ingredients were only present in one of the two supplements.…”

Metabolomic signatures in elite cyclists: differential characterization of a seeming normal endocrine status regarding three serum hormones

“…Here, in testosterone Normal outliers, both choline, α-glycerylphosphorylcholine and probably the related acyl-derivatives of α-glyceryl-phosphorylcholine were decreased when compared to values of subjects from the true Normal class (Figure 4A). This situation could result in this outliers' subgroup from strenuous effort training that could thereby affect endurance characteristics; indeed, as shown by Marcus et al (2017), a daily supplementation for 7 days of α-glyceryl-phosphorylcholine to young men improved maximum velocity and maximum mechanical power on the counter movement jump. This same hypothesis could be also invoked to explain the relative decrease in L-threonine and L-arginine observed in serum of this subgroup of cyclists.…”

“…choline, α-glycerylphosphorylcholine, L-threonine and L-arginine, were decreased in outliers of the Normal class of the testosterone phenotype (Table 2). α-Glycerylphosphorylcholine has been recognized recently as an emerging ergogenics (Bellar et al 2015;Marcus et al 2017) which could favour biosynthesis of choline (Kawamura et al 2012), which depletion was thought to play a possible role in fatigue (Conlay et al 1992) and which is a precursor of acetylcholine, a neurotransmitter, also involved in enhancement of muscular power and strength (Bellar et al 2015;Zeigenfuss et al 2008). An oral choline supplementation might only increase endurance performance (Penry & Manore 2008).…”

Застосування Α-Гліцерилфосфорилхоліну В Схемі Комплексного Лікування Для Функціонального Відновлення Після Мозкового Півкульового Ішемічного Інсульту

“…За даними світової літератури, рання активація після інсульту та якомога раніший початок реабілітаційних заходів знижує ризик повторних інсультів та покращує функціональний вихід, а оскільки в патогенезі постінсультних порушень важливу роль відіграють холінергічна недостатність і структурно-функціональні пошкодження нейронів, доцільним є додаткове застосування лікарських засобів, спрямованих на їх корекцію, зокрема препаратів α-гліцерилфосфорилхоліну [2,[9][10][11][12].…”