Metabolomic signatures in elite cyclists: differential characterization of a seeming normal endocrine status regarding three serum hormones

Paris, Alain; Labrador, Boris; Lejeune, François‐Xavier; Canlet, Cécile; Molina, Jérôme; Guinot, Michel; Mégret, Armand; Rieu, Michel; Thalabard, Jean-Christophe; Bouc, Yves Le

doi:10.1007/s11306-021-01812-4

Cited by 2 publications

(2 citation statements)

References 84 publications

(89 reference statements)

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“…The versatility of the blood metabolome has provided fruitful ground for an impressive body of work investigating rapid [18,19] and slow [20,21] changes in the body. Modern metabolomic approaches allow the identification of characteristic patterns of low molecular weight compounds and associate them with the development of pathologies [22][23][24], lifestyle [25,26], and eating habits [27][28][29] in both personalized mode [10,30,31] and large cohorts [32,33].…”

Section: Serum and Plasma Metabolome As A "Snapshot" Of A Human Biochemistrymentioning

confidence: 99%

Defining Blood Plasma and Serum Metabolome by GC-MS

et al. 2021

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Metabolomics uses advanced analytical chemistry methods to analyze metabolites in biological samples. The most intensively studied samples are blood and its liquid components: plasma and serum. Armed with advanced equipment and progressive software solutions, the scientific community has shown that small molecules’ roles in living systems are not limited to traditional “building blocks” or “just fuel” for cellular energy. As a result, the conclusions based on studying the metabolome are finding practical reflection in molecular medicine and a better understanding of fundamental biochemical processes in living systems. This review is not a detailed protocol of metabolomic analysis. However, it should support the reader with information about the achievements in the whole process of metabolic exploration of human plasma and serum using mass spectrometry combined with gas chromatography.

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Section: Serum and Plasma Metabolome As A "Snapshot" Of A Human Biochemistrymentioning

confidence: 99%

Defining Blood Plasma and Serum Metabolome by GC-MS

et al. 2021

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“…The samples were collected as part of anti-doping controls in or out of competition with a lack of information about the athletes’ age, ethnicity, body mass, or their current training status, all factors with probably considerable effects on the individual metabolome. During the past years, research focused on changes of the basal metabolome of endurance-trained athletes and athletes of different sports in response to a single sport-specific session or multiple training weeks [ 15 , 16 , 17 , 18 , 19 , 20 ]. However, none of these studies investigated the effects of perennial training on the resting metabolome.…”

Section: Introductionmentioning

confidence: 99%

Targeted Metabolomics in High Performance Sports: Differences between the Resting Metabolic Profile of Endurance- and Strength-Trained Athletes in Comparison with Sedentary Subjects over the Course of a Training Year

et al. 2023

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(1) Introduction: Little is known about the metabolic differences between endurance and strength athletes in comparison with sedentary subjects under controlled conditions and about variation of the metabolome throughout one year. We hypothesized that (1) the resting metabolic profile differs between sedentary subjects and athletes and between perennially endurance- and strength-trained athletes and (2) varies throughout one year of training; (2) Methods: We performed quantitative, targeted metabolomics (Biocrates MxP® Quant 500, Biocrates Life Sciences AG, Innsbruck, Austria) in plasma samples at rest in three groups of male adults, 12 strength-trained (weightlifters, 20 ± 3 years), 10 endurance-trained athletes (runners, 24 ± 3 years), and 12 sedentary subjects (25 ± 4 years) at the end of three training phases (regeneration, preparation, and competition) within one training year; (3) Results: Performance and anthropometric data showed significant (p < 0.05) differences between the groups. Metabolomic analysis revealed different resting metabolic profiles between the groups with acetylcarnitines, di- and triacylglycerols, and glycerophospho- and sphingolipids, as well as several amino acids as the most robust metabolites. Furthermore, we observed changes in free carnitine and 3-methylhistidine in strength-trained athletes throughout the training year; (4) Discussion: Regular endurance or strength training induces changes in the concentration of several metabolites associated with adaptations of the mitochondrial energy and glycolytic metabolism with concomitant changes in amino acid metabolism and cell signaling.

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Metabolomic signatures in elite cyclists: differential characterization of a seeming normal endocrine status regarding three serum hormones

Cited by 2 publications

References 84 publications

Defining Blood Plasma and Serum Metabolome by GC-MS

Defining Blood Plasma and Serum Metabolome by GC-MS

Targeted Metabolomics in High Performance Sports: Differences between the Resting Metabolic Profile of Endurance- and Strength-Trained Athletes in Comparison with Sedentary Subjects over the Course of a Training Year

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