Evaluation of the Effects of Intravitreal Aflibercept and Ranibizumab on Systemic Inflammatory and Cardiovascular Biomarkers in Patients with Neovascular Age-related Macular Degeneration

Erdem, Burak; Gök, Mustafa

doi:10.1080/02713683.2021.1879868

Cited by 2 publications

(3 citation statements)

References 33 publications

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“…On the other hand, we found that the biochemical parameter cholesterol was reduced over time, being this reduction bigger in the poor responders group, probably due to having a bigger population on statin treatment. Despite non-responders being on more statins, they have a similar basal cholesterol value between both groups and the lowering of cholesterol occurs in both groups, so it could be a good candidate to monitor response as this reduction was also observed other studies, although it did not reach significance [35,36]. These studies also measured lipoproteins such as HDL and LDL.…”

Section: Discussionmentioning

confidence: 95%

“…We did not find similar results with other studies that used ranibizumab as anti-VEGF treatment [ 45 ]. Erdem et al found significance in the reduction of these parameters when intravitreal aflibercept was used, but not when intravitreal ranibizumab was administered [ 36 ]. Moreover, we also found that poor responders had a significant change over time compared with good responders, but, since all fluctuations of these parameters remained within the stablished therapeutic range after the loading phase, it does not seem likely that these differences would have any clinical effect.…”

Section: Discussionmentioning

confidence: 99%

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The Effect of Systemic Parameters and Baseline Characteristics in Short-Term Response Analysis with Intravitreal Ranibizumab in Treatment-Naive Patients with Neovascular Age-Related Macular Degeneration

García-Quintanilla,

Almuiña-Varela,

Rodríguez-Cid

et al. 2024

Pharmaceutics

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Anti-vascular endothelial growth factor drugs keep being the main therapy for neovascular age-related macular degeneration (AMD). Possible predictive parameters (demographic, biochemical and/or inflammatory) could anticipate short-term treatment response with ranibizumab. 46 treatment-naive patients were included in a prospective observational study. They underwent three monthly injections of intravitreal ranibizumab for neovascular AMD and the clinical examination was made at baseline and one month after the third injection. Demographic characteristics, co-morbidities and concomitant treatments were recorded at the baseline visit. Biochemical parameters, complete blood count and inflammation biomarkers were also measured at these times. Uric Acid was found to be statistically significant with a one-point difference between good and poor responders in both basal and treated patients, but only in basal parameters was statistical significance reached (p = 0.007 vs. p = 0.071 in treated patients). Cholesterol and inflammatory parameters such as white blood cell count and neutrophils were significantly reduced over time when treated with intravitreal ranibizumab. On the other hand, women seemed to have a worse prognosis for short-term response to intravitreal ranibizumab treatment. Uric acid may help identify possible non-responders before initial treatment with ranibizumab, and cholesterol and white blood cells could be good candidates to monitor short-term response to ranibizumab treatment.

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Section: Discussionmentioning

confidence: 95%

Section: Discussionmentioning

confidence: 99%

The Effect of Systemic Parameters and Baseline Characteristics in Short-Term Response Analysis with Intravitreal Ranibizumab in Treatment-Naive Patients with Neovascular Age-Related Macular Degeneration

García-Quintanilla,

Almuiña-Varela,

Rodríguez-Cid

et al. 2024

Pharmaceutics

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“…CAR serves as a valuable clinical indicator, offering insights into both the inflammatory response and nutritional status in patients with a comprehensive range of conditions. It has been widely employed to forecast the prognosis of various infectious diseases due to the convenience of obtaining test results [27][28][29][30][31][32][33][34][35]. CAR encompass two key components: CRP and ALB.…”

Section: Discussionmentioning

confidence: 99%

The Development and Evaluation of a Prediction Model for Kidney Transplant-Based Pneumocystis carinii Pneumonia Patients Based on Hematological Indicators

Zhang,

Liu,

Zou

et al. 2024

Biomedicines

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Background: This study aimed to develop a simple predictive model for early identification of the risk of adverse outcomes in kidney transplant-associated Pneumocystis carinii pneumonia (PCP) patients. Methods: This study encompassed 103 patients diagnosed with PCP, who received treatment at our hospital between 2018 and 2023. Among these participants, 20 were categorized as suffering from severe PCP, and, regrettably, 13 among them succumbed. Through the application of machine learning techniques and multivariate logistic regression analysis, two pivotal variables were discerned and subsequently integrated into a nomogram. The efficacy of the model was assessed via receiver operating characteristic (ROC) curves and calibration curves. Additionally, decision curve analysis (DCA) and a clinical impact curve (CIC) were employed to evaluate the clinical utility of the model. The Kaplan–Meier (KM) survival curves were utilized to ascertain the model’s aptitude for risk stratification. Results: Hematological markers, namely Procalcitonin (PCT) and C-reactive protein (CRP)-to-albumin ratio (CAR), were identified through machine learning and multivariate logistic regression. These variables were subsequently utilized to formulate a predictive model, presented in the form of a nomogram. The ROC curve exhibited commendable predictive accuracy in both internal validation (AUC = 0.861) and external validation (AUC = 0.896). Within a specific threshold probability range, both DCA and CIC demonstrated notable performance. Moreover, the KM survival curve further substantiated the nomogram’s efficacy in risk stratification. Conclusions: Based on hematological parameters, especially CAR and PCT, a simple nomogram was established to stratify prognostic risk in patients with renal transplant-related PCP.

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Evaluation of the Effects of Intravitreal Aflibercept and Ranibizumab on Systemic Inflammatory and Cardiovascular Biomarkers in Patients with Neovascular Age-related Macular Degeneration

Cited by 2 publications

References 33 publications

The Effect of Systemic Parameters and Baseline Characteristics in Short-Term Response Analysis with Intravitreal Ranibizumab in Treatment-Naive Patients with Neovascular Age-Related Macular Degeneration

The Effect of Systemic Parameters and Baseline Characteristics in Short-Term Response Analysis with Intravitreal Ranibizumab in Treatment-Naive Patients with Neovascular Age-Related Macular Degeneration

The Development and Evaluation of a Prediction Model for Kidney Transplant-Based Pneumocystis carinii Pneumonia Patients Based on Hematological Indicators

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