Evaluation of the effects of Vitamin C on Epithelialization of Burn Wounds: A Randomized Clinical Trial

Abstract

Objectives The purpose of this study is to determine the effect of topical vitamin C on second-degree burn wounds restoration. This was a clinical trial. The sample size was determined as 30. Participants were selected from patients suffering from second-degree burns who visited the Burn Center of Vaseei Hospital in Sabzevar. Both intervention and control groups targeted one patient.Dressing was changed in a daily manner after cleansing. A topical vitamin C solution was administered on the wounds. The Bates-Jensen Wound Assessment Tool was used to evaluate burn wound parameters in the 1 st , 3 rd , 7 th , and 14 th days of treatment. Data was analyzed using SPSS v.16 and ‘’repeated measures ANOVA. Results The average age of participants was 43.33 ± 11.9 years and 60% of the participants were males and 40% of them were females. The results of repeated measures ANOVA showed a statistically significant difference in mean scores of the wound between the two treatments (P = 0.047), wound healing significantly differed in the two groups and topical vitamin C solution had a significant effect on the acceleration of wound Epithelialization. The administration of topical vitamin C is recommended for epithelialization of second-degree burns.