Evaluation of the Effects of Sennosides on Uterine Motility in the Pregnant Ewe

Garcia‐Villar, R.

doi:10.1159/000138441

Cited by 7 publications

(4 citation statements)

References 11 publications

(17 reference statements)

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“…After pretreating rats with sennosides we registered a decrease in contractility of the isolated uterus which resembles the outcome of experiments in pregnant ewes [8], On the contrary, the studies in isolated rat uterus showed no change in contractions unless the bath solution of rhein-Na was augmented to extreme concentrations of 3 X 10~4 mol/1 or higher. In spite of the difficulties known for calculating the unstable patterns of more or less rhythmic contractions in isolated uter ine tissue, the impression prevails that it was an unspecific irritation of the tissue by rheinNa which enhanced contractility.…”

Section: Discussionsupporting

confidence: 73%

In vitro Effects of Anthraquinones on Rat Intestine and Uterus

Odenthal¹,

Ziegler²

1988

Pharmacology

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Isolated uterus and colon segments were taken from sennoside-pretreated female rats. They indicate a possible decrease in spontaneous contractility of both organ segments. Addition of rhein-Na, as one of the probable active metabolites of sennosides, into the bath medium of isolated colon and ileum segments of untreated rats showed a reduction in contractility at concentrations of more than 10^–5 and 10^–4 mol/l, respectively. Though rhein-Na in concentrations of more than 10^–4 mol/l impaired acetylcholine-mediated contractures of isolated colon, the antagonism was obviously partial and noncompetitive. Isolated uteri from previously estrogen-treated rats did not show a change in the contractile behaviour up to concentrations of 10^–4 mol/l rhein-Na, whereas higher concentrations induced an increase in contractions. The importance of this finding is not clear.

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Section: Discussionsupporting

confidence: 73%

In vitro Effects of Anthraquinones on Rat Intestine and Uterus

Odenthal¹,

Ziegler²

1988

Pharmacology

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“…Der Übertritt von Sennosiden in die Muttermilch ist minimal, die kindlichen Stühle werden nicht weicher [242][243][244]. Aborte werden nicht begünstigt [245,246]. Die oft behauptete Gewöhnung an Sennoside scheint sehr selten zu sein, systematische Untersuchungen hierzu fehlen jedoch.…”

Section: Kommentarunclassified

Aktualisierte S2k-Leitlinie chronische Obstipation der Deutschen Gesellschaft für Gastroenterologie, Verdauungs- und Stoffwechselkrankheiten (DGVS) und der Deutschen Gesellschaft für Neurogastroenterologie & Motilität (DGNM) – April 2022 – AWMF-Registriernummer: 021–019

Andresen

Pehl²,

Becker³

et al. 2022

Z Gastroenterol

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“…The abortifacient effects related to the use of medicinal plants in pregnancy, are also reported in the literature [4,[21][22][23][28][29][30][31][32]. As example of the abortifacient plants are: Senna alexandrina Mill (Fabaceae) (sene) [4,30,33,[35][36][37], Rhamnus purshiana DC (Rhamnaceae) and Rhamnus catharticus (Rhamnaceae) (cáscara-sagrada) [4,30,31,37], Mentha pulegium L. (Lamiaceae) (poejo) [4,[38][39][40], Mentha arvensis L. (Lamiaceae) (hortelã-japonesa) [4,41], Chenopodium ambrosioides L.…”

Section: Perception Of Health Risksmentioning

confidence: 99%

Medicinal Plants in Pregnancy and Lactation: Perception of the Health Risk and Practical Educational Group in Araraquara, São Paulo State, Brazil

Moreira¹

2014

J Gen Pract

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The use of medicinal plants among pregnant women and lactating is a common practice in diverse countries. However, many medicinal plants are contraindicated during pregnancy and lactating, due to various adverse effects, such as teratogenic, embryotoxic and abortive effects, exposing these women, their fetus and babies to health unknown risks. Thus, the purpose of this commentary, was to analyze the perception about the use of medicinal plants by pregnant women and lactating registered in the "baby on board" NGO, Araraquara, São Paulo state, Brazil, between 2010 at 2013. The group was constituted by 48 women, between the first and last trimester of pregnancy or whilst breastfeeding. Information was collected during group meetings by oral interview, using a questionnaire, as script. The nature of the study was a qualitative analysis. The results were based on reports about the use of medicinal plants by pregnant women during group meetings: use, indication of use, knowledge about risks. All participants received written and oral information about the study and they gave a written informed consent. The use of medicinal plants is a reality among pregnant and lactating women of the "baby on board" NGO. They reported that they feel that "natural" products are not harmful for their health. The primary information sources for the majority of women about medicinal plants during pregnancy are family, neighbors and herbalists. The plants most cited were: senna, chamomile, boldo, lemon balm, lemon grass. They were used mainly for: nausea, heartburn, indigestion, flatulence, intestinal and abdominal pain, anxiety, intestinal constipation and low milk production. The pregnant and lactating women lacked knowledge about the health risks of the use of medicinal plants and herbal medicines in pregnancy and lactation. They also reported difficulties in clarifying some questions about the use of medicinal plants with their doctors. The results of the present study showed that educative actions about the rational use of medicinal plants in pregnancy and breastfeeding could be part of the operating protocols to promote the maternal and child health programs in Araraquara. Thus, our results also suggest the importance of creating institutionalized places, to the implementation of continued education programs about rational use of medicinal plants in pregnancy and lactation. These targeted programs are not only for health professionals, but also for community members, pregnant women and breastfeeding. Our results pointed out the importance of guidance of doctors and healthcare professionals on the scientific studies about medicinal plants and herbal medicines and the risk/benefit of using herbs during pregnancy. Finally, it is noted the importance of the health professionals to inform women of childbearing on risks to their health, as well as on possibilities of utilization of herbs during fertile period, giving special attention to the potential risk of self-medication.

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Evaluation of the Effects of Sennosides on Uterine Motility in the Pregnant Ewe

Cited by 7 publications

References 11 publications

In vitro Effects of Anthraquinones on Rat Intestine and Uterus

In vitro Effects of Anthraquinones on Rat Intestine and Uterus

Aktualisierte S2k-Leitlinie chronische Obstipation der Deutschen Gesellschaft für Gastroenterologie, Verdauungs- und Stoffwechselkrankheiten (DGVS) und der Deutschen Gesellschaft für Neurogastroenterologie & Motilität (DGNM) – April 2022 – AWMF-Registriernummer: 021–019

Medicinal Plants in Pregnancy and Lactation: Perception of the Health Risk and Practical Educational Group in Araraquara, São Paulo State, Brazil

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