Evaluation of the effect of shift working and sleep quality on semen parameters in men attending infertility clinic

Demirkol, Mehmet; Yıldırım, Abdullah; Gıca, Şakir; Doğan, Neslihan; Resim, Sefa

doi:10.1111/and.14116

Cited by 17 publications

(15 citation statements)

References 27 publications

(39 reference statements)

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“…Sleep is a repetitive behavior that synchronizes with daily circadian rhythms, and a regular wake/sleep cycle is essential for human health ( 29 ). Shiftwork refers to working beyond the traditional daytime (08:00 to 16:00), which covers rotating or non-rotating (fixed) shift models ( 29 , 58 ). The European Working Condition Survey in 2005 estimated that more than 17% of staff in the European Union performed shiftwork ( 29 ).…”

Section: Shiftwork and Male Fertilitymentioning

confidence: 99%

“…Shiftwork refers to working beyond the traditional daytime (08:00 to 16:00), which covers rotating or non-rotating (fixed) shift models ( 29 , 58 ). The European Working Condition Survey in 2005 estimated that more than 17% of staff in the European Union performed shiftwork ( 29 ). Several studies have shown that shiftwork disturbed the wake/sleep cycle and impaired circadian rhythms, which contributed to cardiovascular disorders, metabolic diseases, and male infertility ( 29 , 59 ) ( Figure 2 ).…”

Section: Shiftwork and Male Fertilitymentioning

confidence: 99%

“…Although humans are not seasonal breeders, their sexual activity ( 24 , 25 ) and reproductive function are still influenced by the peripheral environment ( 24 , 26 ), although relatively less ( 27 , 28 ). Infertility is defined as the inability to successfully spontaneously conceive for at least 2 years of unprotected sexual intercourse and is influenced by occupational and lifestyle factors such as smoking, obesity, alcohol consumption, psychological stress, and lack of exercise ( 29 , 30 ). Currently, infertility affects nearly 15–20% of all couples worldwide ( 24 , 30 ) and contributes to various psychological, medical, and financial consequences ( 30 ).…”

Section: Introductionmentioning

confidence: 99%

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The potential impacts of circadian rhythm disturbances on male fertility

Bai

Jiang³

et al. 2022

Front. Endocrinol.

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A circadian rhythm is an internalized timing system that synchronizes the cellular, behavioral, and physiological processes of organisms to the Earth’s rotation. Because all physiological activities occur at a specific time, circadian rhythm disturbances can lead to various pathological disorders and diseases. Growing evidence has shown that the circadian clock is tightly connected to male fertility, and circadian perturbations contribute to infertility. The night shiftwork, insufficient sleep, and poor sleep quality are common causes of circadian disturbances, and many studies have reported that they impair sperm quality and increase the risk of male infertility. However, research on the impacts of light, body temperature, and circadian/circannual rhythms is relatively lacking, although some correlations have been demonstrated. Moreover, as the index of sperm quality was diverse and study designs were non-uniform, the conclusions were temporarily inconsistent and underlying mechanisms remain unclear. A better understanding of whether and how circadian disturbances regulate male fertility will be meaningful, as more scientific work schedules and rational lifestyles might help improve infertility.

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Section: Shiftwork and Male Fertilitymentioning

confidence: 99%

Section: Shiftwork and Male Fertilitymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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The potential impacts of circadian rhythm disturbances on male fertility

Bai

Jiang³

et al. 2022

Front. Endocrinol.

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“…Poor sleep quality was related to the risk of asthenozoospermia but only among participants who drank tea and those with rotating night shift work. The exact reason is unclear, but underlying mechanisms might be that tea polyphenols (Qi et al, 2017) and rotating night shift work Frontiers in Physiology frontiersin.org (Demirkol et al, 2021) have an influence on circadian rhythms that can affect male reproduction (Peterlin et al, 2019). Potential mechanisms underlying the association between sleep and male infertility might involve many aspects, such as endocrinology, metabolism, and stress.…”

Section: Discussionmentioning

confidence: 99%

Short total sleep duration and poor sleep quality might be associated with asthenozoospermia risk: A case-control study

Wang²,

Wu³

et al. 2022

Front. Physiol.

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Sleep has been related to a variety of health outcomes. However, no association between sleep and asthenozoospermia has been reported. The aim of this study is to first investigate the relationship between sleep status and asthenozoospermia risk. A case-control study, including 540 asthenozoospermia cases and 579 controls, was performed from June 2020 to December 2020 in the infertility clinic from Shengjing Hospital of China Medical University. Data on sleep status were collected by Pittsburgh sleep quality index questionnaires and asthenozoospermia was diagnosed based on the World Health Organization guidelines. Odds ratio (OR) with 95% confidence interval (95% CI) was calculated by logistic regression analysis to assess the aforementioned association. Results of this study demonstrated that compared with total sleep duration of 8–9 h/day, < 8 h/day was related to asthenozoospermia risk (OR: 1.44, 95% CI: 1.05–1.99); compared to good sleep quality, poor sleep quality was associated with asthenozoospermia risk (OR: 1.35; 95% CI: 1.04–1.77). There were multiplicative model interaction effects between sleep quality and tea drinking (p = 0.04), rotating night shift work (p < 0.01) on asthenozoospermia risk. However, we failed to detect any associations between night sleep duration, daytime napping duration, night bedtime, wake-up time, sleep pattern and asthenozoospermia risk. In conclusion, short total sleep duration and poor sleep quality might be related to asthenozoospermia risk. Further well-designed prospective studies are warranted to confirm our findings.

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“…No equivalent studies are available to examine the effect of circadian misalignment on testosterone rhythms. Such studies would be valuable because symptoms consistent with hypogonadism are common in night shiftworkers, particularly those with shiftwork sleep disorder [ 99 – 101 ], and understanding whether circadian misalignment per se can directly alter testosterone levels and induce hypogonadism would inform treatment strategies.…”

Section: Effect Of Circadian Misalignment On Testosterone and Cortisolmentioning

confidence: 99%

Sleep, testosterone and cortisol balance, and ageing men

Liu

Reddy

2022

Rev Endocr Metab Disord

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Sleep serves important biological functions, and influences health and longevity through endocrine and metabolic related systems. Sleep debt, circadian misalignment and sleep disruption from obstructive sleep apnea is widespread in modern society and accumulates with life because recovery sleep is not completely restorative. Accumulated disordered sleep throughout life impacts the ageing process and the development of age-related diseases. When epidemiological and interventional studies are considered collectively, sleep loss and lower sleep duration are associated with lower morning, afternoon and 24-h testosterone; as well as higher afternoon, but not morning or 24-h cortisol. These reciprocal changes imbalances anabolic-catabolic signaling because testosterone and cortisol are respectively the main anabolic and catabolic signals in man. Fixing testosterone-cortisol balance by means of a novel dual-hormone clamp mitigates the induction of insulin resistance by sleep restriction and provided the first proof-of-concept that the metabolic harm from sleep loss can be ameliorated by approaches that do not require sleeping more. Obstructive sleep apnea is associated with lower testosterone, even after controlling for age and obesity whereas the conclusion that continuous positive airway pressure therapy has no effect on testosterone is premature because available studies are underpowered and better-quality studies suggest otherwise. High dose testosterone therapy induces OSA, but more physiological dosing may not; and this effect may be transient or may dissipate with longer term therapy. Studies investigating the origin of the diurnal testosterone rhythm, the effect of circadian misalignment on testosterone-cortisol balance, and methods to mitigate metabolic harm, are required.

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Evaluation of the effect of shift working and sleep quality on semen parameters in men attending infertility clinic

Cited by 17 publications

References 27 publications

The potential impacts of circadian rhythm disturbances on male fertility

The potential impacts of circadian rhythm disturbances on male fertility

Short total sleep duration and poor sleep quality might be associated with asthenozoospermia risk: A case-control study

Sleep, testosterone and cortisol balance, and ageing men

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