Short total sleep duration and poor sleep quality might be associated with asthenozoospermia risk: A case-control study

Li, Xiaoying; Wang, Xiaobin; Wu, Qi‐Jun; Guo, Renhao; Leng, Xu; Du, Qiang; Pan, Bochen; Zhao, Yuhong

doi:10.3389/fphys.2022.959009

Cited by 8 publications

(11 citation statements)

References 43 publications

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“…Based on previous literatures, we considered age, sex, marital status, multimorbidity, anxiety symptoms and depression symptoms as potential confounders. But education level, tea drinking, and napping duration were significant ( p < 0.05) in comparisons of intergroup differences, which meant these three variables might be related to SCC, and previous studies indicated that they also be linked with sleep 33–36 . Thus, eventually, we included age, sex, residence, education level, marital status, smoking, tea drinking, multimorbidity, napping duration, anxiety symptoms, and depression symptoms in our final model.…”

Section: Methodsmentioning

confidence: 93%

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Association of subjective cognitive complaints with poor sleep quality: A cross‐sectional study among Chinese elderly

Song

Wang

et al. 2023

Int J Geriat Psychiatry

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Objectives: Subjective cognitive complaints (SCC) are the earliest symptom of Alzheimer's disease (AD) progression. Increasing evidence shows an association between poor sleep quality and SCC, but the current conclusions regarding the association between poor sleep quality and SCC in older adults are contradictory.Here, we aimed to explore the correlation of SCC with poor sleep quality among older adults without dementia living in nursing home and community in China. Methods: A cross-sectional survey on sleep and psychosomatic health of older adults was conducted in Guangdong, China, between November 2020 and March 2021. Socio-demographic, health-related information, psychological factors, sleep quality and SCC of participants were evaluated through a face-to-face interview. A 9-item Subjective Cognitive Decline Questionnaire (SCD-Q9) was used to measure SCC; SCD-Q9 > 3 was defined as SCC. The Chinese version of the Pittsburgh Sleep Quality Index (PSQI) was used to evaluate sleep quality; PSQI > 7 was defined as poor sleep quality. The relationship between SCC and sleep quality was evaluated using logistics regression analysis. Results:The study involved 730 participants (mean age 74.14 � 8.246 years). The total SCC prevalence was 59.59%. The SCC group had poor sleep quality than the reference group (p < 0.05). Adjusted multiple logistic regression analysis revealed an association of poor sleep quality with SCC (OR = 1.841; 95% CI, 1.267-2.647; p = 0.001) after controlling for age, sex, residence, education level, marital status, income, smoking, alcohol consumption, tea drinking, multimorbidity, waist circumference, napping duration, anxiety symptoms, and depression symptoms. Hierarchical logistics regression analysis showed an association between sleep quality and SCC among community older adults (OR = 2.872; 95% CI: 1.787-4.615; p < 0.001), but not in nursing home residents (OR = 0.845; 95% CI: 0.437-1.637; p = 0.619). Conclusions:Poor sleep quality is associated with SCC in community older adults.Therefore, medical staff should take measures, such as earlier cognitive intervention, to postpone cognitive decline in older adults, in the meantime, earlier management and treatment of sleep disorders should be taken into consideration.

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Section: Methodsmentioning

confidence: 93%

“…T A B L E 1iables might be related to SCC, and previous studies indicated that they also be linked with sleep [33][34][35][36]. Thus, eventually, we included age, sex, residence, education level, marital status, smoking, tea drinking, multimorbidity, napping duration, anxiety symptoms, and depression symptoms in our final model.…”

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confidence: 99%

Association of subjective cognitive complaints with poor sleep quality: A cross‐sectional study among Chinese elderly

Song

Wang

et al. 2023

Int J Geriat Psychiatry

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“…Our research center is located in a mega city of China with high talent competition and socioeconomic burden, and one notable feature that sets it apart from other cities is the high level of work pressure, which, in turn, leads to reduced sleep time, high psychosocial stress, and irregular eating. Studies reported that short sleep durations, late bedtime, and poor sleep quality were associated with impaired sperm health ( 70 , 71 ). Psychosocial stress was also negatively associated with sperm concentration, total count, and motility ( 72 – 74 ).…”

Section: Discussionmentioning

confidence: 99%

Trends in sperm quality by computer-assisted sperm analysis of 49,189 men during 2015–2021 in a fertility center from China

et al. 2023

Front. Endocrinol.

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BackgroundSperm quality, including semen volume, sperm count, concentration, and total and progressive motility (collectively, “semen parameters”), has declined in the recent decades. Computer-assisted sperm analysis (CASA) provides sperm kinematic parameters, and the temporal trends of which remain unclear. Our objective is to examine the temporal trend of both semen parameters and kinematic parameters in Shanghai, China, in the recent years.MethodsThis retrospective study analyzed semen parameters and kinematic parameters of 49,819 men attending our reproductive center by using CASA during 2015–2021. The total sample was divided into two groups: samples that surpassed the WHO guideline (2010) low reference limits (“above reference limit” group, ARL; n = 24,575) and samples that did not (“below reference limit” group, BRL; n = 24,614). One-way analysis of variance, Kruskal–Wallis test, independent samples t-test, and covariance analysis were used to assess the differences among groups. Year, age, and abstinence time were included in the multiple linear regression model of the ARL group to adjust the confounders and depict the trends in sperm quality.ResultsAmong all the total sample and the ARL and BRL groups, the age of subjects increased in recent years. Semen volume and sperm count showed declined tendency with years in the total sample, the ARL and BRL groups, and the subgroup of age or abstinence time, whereas sperm velocities showed increased tendency with years on the contrary. The multiple linear regression model of the ARL group, adjusting for age and abstinence time, confirmed these trends. Semen volume (β1= −0.162; CI: −0.172, −0.152), sperm count (β1= −9.97; CI: −10.813, −9.128), sperm concentration (β1 = −0.535; CI: −0.772, −0.299), motility (β1 = −1.751; CI: −1.830, −1.672), and progressive motility (β1 = −1.12; CI: −0.201, −0.145) decreased with year, whereas curvilinear line velocity (VCL) (β1 = 3.058; CI: 2.912, 3.203), straight line velocity (VSL) (β1 = 2.075; CI: 1.990, 2.161), and average path velocity (VAP) (β1 = 2.305; CI: 2.224, 2.386) increased over time (all p < 0.001). In addition, VCL, VSL, and VAP significantly declined with age and abstinence time.ConclusionThe semen parameters declined, whereas the kinematic parameters increased over the recent years. We propose that, although sperm count and motility declined over time, sperm motion velocity increased, suggesting a possible compensatory mechanism of male fertility.

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“…External quality control was conducted by experienced technicians through a national quality control program on semen analysis, which was organized by the Society of Reproductive Medicine, Chinese Medical Association ( Li et al , 2022 ). The test items included SC, TSC, total motility, and sperm morphology.…”

Section: Methodsmentioning

confidence: 99%

Phytochemical consumption and the risk of teratozoospermia: findings from a hospital-based case–control study in China

Zhao

Wang

et al. 2023

Human Reproduction Open

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STUDY QUESTION Are dietary phytochemicals associated with the risk of teratozoospermia? SUMMARY ANSWER Dietary intake of carotene, including total carotene, α-carotene, β-carotene as well as retinol equivalent, and lutein + zeaxanthin, were inversely correlated with the risk of teratozoospermia. WHAT IS KNOWN ALREADY Phytochemicals are natural plant derived bioactive compounds, which have been reported to be potentially associated with male reproductive health. To date, no study has investigated the association between phytochemical intake and the risk of teratozoospermia. STUDY DESIGN, SIZE, DURATION This hospital-based case-control study, which included 146 newly diagnosed teratozoospermia cases and 581 controls with normozoospermia from infertile couples, was conducted in a hospital-based infertility clinic in China, from June 2020 to December 2020. PARTICIPANTS/MATERIALS, SETTING, METHODS Dietary information was collected using a validated semi-quantitative 110-item food frequency questionnaire. Unconditional logistic regression was applied to estimate odds ratios (ORs) and 95% CIs for the associations between phytochemical (i.e., phytosterol, carotene, flavonoid, isoflavone, anthocyanidin, lutein + zeaxanthin, and resveratrol) intake and the risk of teratozoospermia. MAIN RESULTS AND THE ROLE OF CHANCE We observed a decreased risk of teratozoospermia for the highest compared with the lowest tertile consumption of total carotene (OR = 0.40, 95% CI = 0.21-0.77), α-carotene (OR = 0.53, 95% CI = 0.30-0.93), β-carotene (OR = 0.47, 95% CI = 0.25-0.88), retinol equivalent (OR = 0.47, 95% CI = 0.24-0.90), and lutein + zeaxanthin (OR = 0.35, 95% CI = 0.19-0.66), with all of the associations showing evident linear trends (all P trend < 0.05). In addition, significant dose-response associations were observed between campestanol and α-carotene consumption and the risk of teratozoospermia. Moreover, there was a significant multiplicative interaction between BMI and lutein + zeaxanthin intake (P interaction < 0.05). LIMITATIONS, REASONS FOR CAUTION The cases and controls were not a random sample of the entire target population, which could lead to admission rate bias. Nevertheless, the controls were enrolled from the same infertility clinic, which could reduce the bias caused by selection and increase the comparability. Furthermore, our study only included a Chinese population, therefore caution is required regarding generalization of our findings to other populations. WIDER IMPLICATIONS OF THE FINDINGS Dietary phytochemicals, namely carotene, lutein, and zeaxanthin, might exert a positive effect on teratozoospermia. These phytochemicals are common in the daily diet and dietary supplements, and thus may provide a preventive intervention for teratozoospermia. STUDY FUNDING/COMPETING INTEREST(S) : This study was funded by Natural Science Foundation of Liaoning Province (No. 2022-MS-219 to XB Wang), Outstanding Scientific Fund of Shengjing Hospital (No. M1150 to QJ Wu), Clinical Research Cultivation Project of Shengjing hospital (No. M0071 to BC Pan), and JieBangGuaShuai Project of Liaoning Province (No.2021JH1/1040050 to YH Zhao). All authors declare that there is no conflict of interest. TRIAL REGISTRATION NUMBER N/A. WHAT DOES THIS MEAN FOR PATIENTS? Teratozoospermia, a condition which is characterized by the majority of sperm having an abnormal structure, is a common cause of male infertility yet, at present, there is no effective treatment. Available evidence indicates that several physiological, environmental, and genetic factors may cause teratozoospermia, but these factors are difficult to modify. Therefore, the identification of factors that could be changed is important for the prevention of teratozoospermia. Previous studies also report that diet, as a potentially modifiable factor, is correlated to sperm morphology. Phytochemicals are a group of naturally bioactive compounds that exist in multiple plant foods, and they may have effects on sperm quality. However, based on only a few studies, current evidence for an association between dietary phytochemical intake and risk of teratozoospermia is inconclusive. Hence, we performed a large case-control study where we compared 146 men with teratozoospermia to 581 healthy controls with normal sperm. Our results showed that dietary intake of phytochemicals, specifically carotene and lutein + zeaxanthin, was linked to a decreased risk of teratozoospermia. These findings shed some light on the effect of phytochemicals on the development of teratozoospermia. If further studies, also in non-Chinese populations, are carried out and confirm our results, the possibility may then exist to reduce sperm abnormalities in this condition through diet.

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Short total sleep duration and poor sleep quality might be associated with asthenozoospermia risk: A case-control study

Cited by 8 publications

References 43 publications

Association of subjective cognitive complaints with poor sleep quality: A cross‐sectional study among Chinese elderly

Association of subjective cognitive complaints with poor sleep quality: A cross‐sectional study among Chinese elderly

Trends in sperm quality by computer-assisted sperm analysis of 49,189 men during 2015–2021 in a fertility center from China

Phytochemical consumption and the risk of teratozoospermia: findings from a hospital-based case–control study in China

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