Evaluation of the effect of hyoscine-N-butyl bromide on the cardiovascular actions of detomidine in the horse

Comparative study between atropine and hyoscine-N-butylbromide for reversal of detomidine induced bradycardia in horses

“…Routine use of anticholinergics in combination with detomidine and other α 2 agonists in horses is not recommended because it may result in substantial increases in myocardium oxygen consumption and has the potential for causing myocardial hypoxia as a consequence of a mismatch between myocardial oxygen delivery and consumption (Marques et al . 1998; Valadão et al . 2000).…”

“…Hyoscine is a nonselective muscarinic antagonist that produces minimal changes in the motility pattern of the small intestine pattern in ponies (Davies and Gerring 1983) and prevents α 2 agonist‐induced bradycardia in horses (Marques et al . 1998; Valadão et al . 2000).…”

Hyoscine-N-butylbromide premedication on cardiovascular variables of horses sedated with medetomidine

“…; Valadão et al. ; Borer & Clarke ). Use of anticholinergics in horses has been restricted because of their potential to induce Ileus (Ducharme & Fubini ; Singh et al.…”

Comparação dos efeitos da romifidina e de uma emulsão de amitraz na sedação e na atividade locomotora espontânea de eqüinos

“…Despite several authors' statements that amitraz is an alpha-2 agonist drug 12,13,14,17,18 , there are no pharmacological studies that establish its specificity to this receptor. Thus, a clinical comparison between amitraz and romifidine, which is a potent alpha-2 agonist 24,25 , is proposed as an efficient method to establish possibilities of using amitraz as an intense and long lasting sedative for horses.…”

“…9,10,11 Amitraz showed central effects of alpha-2 adrenoceptor agonist, inducing similar ataxia, intestinal stasis, behavioral, cardiovascular, muscular and diuretic effects. 12,13,14,15,16,17 These effects could provide an indication for the use of amitraz for sedation practices in veterinary medicine, and this might be particularly appealing in horses because of its low price and its potential analgesic and muscle relaxing effects. 18 Considering the well known effects of romifidine on horses, mediated by its highly specific action on alpha-2 adrenoceptors, this behavioral study proposes to compare its sedative effects with those induced by an emulsion of amitraz, in order to determine the possibility of using this drug as a sedative for horses.…”