Evaluation of the dopaminergic system with positron-emission tomography in alcohol abuse: A systematic review

Alexandre, Maria Cecília Manenti; Colonetti, Tamy; Bavaresco, Daniela V.; Simon, Carla Sasso; Dondossola, Eduardo Ronconi; Uggioni, Maria Laura Rodrigues; Ferraz, Sarah Dagostin; Rico, Eduardo Pacheco; Rosa, Maria Inês da

doi:10.1016/j.psychres.2019.112542

Cited by 5 publications

(8 citation statements)

References 42 publications

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“…Therefore, simplified methods have been developed to estimate surrogates of the BP. So-called reference tissue methods 119, 127–131 do not require blood sampling but instead “compare” the time activity curve in the ROI to the time activity curve in a “reference” region in the brain [9, 10]. The reference region is assumed (i) to be void of the imaging target (e.g., the D2 receptor) and (ii) to show the same non-displaceable (by complete blocking of the target) tracer kinetics as the ROI [128, 132].…”

Section: Confounders Associated With Pet and Spect Methodologymentioning

confidence: 99%

“…NOS rates nonrandomized case-control studies using eight items categorized into the three following groups: (1) selection of study participants, (2) population comparability, and (3) verification as to whether exposure or outcome includes any risk of bias, selection bias, or bias of response rate between the groups. The NOS sum score ranges from 0 to 9, and studies with scores ≥7 are considered high quality [9]. The selection group comprises four items, with 0–1 point, respectively, leading to a maximum score of 4 points.…”

Section: Quality Assessment Of Included Studiesmentioning

confidence: 99%

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Dopamine and Alcohol: A Review of in vivo PET and SPECT Studies

Spitta,

Garbusow,

Buchert

et al. 2023

Neuropsychobiology

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Background: Alcohol-associated alterations of the dopaminergic (DA) system have been investigated via functional single-photon emission tomography (SPECT) positron emission tomography (PET) and imaging methods over many years, investigating presynaptic or postsynaptic markers, such as DA receptor and DA transporter availability, both with and without challenge. This review summarizes SPECT and PET studies on different levels of alcohol consumption to support the dimensional view of alcohol use disorder (AUD), ranging from acute consumption in social drinkers, individuals at high risk to patients with severe AUD and their association with blunted DA neurotransmission. Additionally, confounding factors of PET and SPECT studies of the DA system were discussed. Summary: The included studies provided strong evidence that acute alcohol administration in social drinkers is followed by a DA release, particularly in the ventral striatum. In participants with AUD, DA release appears to be impaired as administration of a psychostimulant is followed by a blunted striatal DA. Furthermore, in recently detoxified participants with AUD, in vivo dopamine D2 and D3 receptor availability appears to be reduced, which may be a predisposing factor or the result of a neuroadaptive process influencing drug-induced DA release. DA transporter availability is reduced in AUD, whereas findings with respect to DA synthesis capacity are controversial. Key Messages: The DA system seems to be differently impaired during the development and persistence of AUD. In total, challenge studies (acute alcohol or psychostimulant administration) seem to be more consistent in their findings and might be less prone to the effects of confounders. Long-term studies with larger samples are required to better evaluate the alterations during chronic consumption and prolonged abstinence.

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Section: Confounders Associated With Pet and Spect Methodologymentioning

confidence: 99%

Section: Quality Assessment Of Included Studiesmentioning

confidence: 99%

Dopamine and Alcohol: A Review of in vivo PET and SPECT Studies

Spitta,

Garbusow,

Buchert

et al. 2023

Neuropsychobiology

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“…Addiction-related changes in the mesolimbic dopamine (DA) system may reflect acute DA release in the nucleus accumbens after, for example, alcohol consumption, leading to reward and consequently reinforcement of addiction-related behaviors [3,4]. In chronic alcohol abuse, reductions in striatal dopamine D2/3 receptor availability have been shown in several recent positron emission tomography (PET) studies and 2 recent metaanalyses [5,6]. Specifically, reductions were observed in the nucleus accumbens, the putamen and the caudate nucleus of alcohol use disorder (AUD) compared to healthy controls (HCs) and have been associated with several alcohol-related behaviors such as craving symptoms and increased relapse probabilities in AUD [7][8][9][10].…”

Section: Introductionmentioning

confidence: 99%

Extrastriatal Dopamine D2/3 Receptor Availability in Alcohol Use Disorder and Individuals at High Risk

Spitta¹,

Gleich²,

Zacharias³

et al. 2022

Neuropsychobiology

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Introduction: Reduced striatal dopamine D2/3 receptor availability in alcohol use disorder (AUD) has been demonstrated in recent clinical studies and meta-analyses. However, only a limited number of studies investigated extrastriatal D2/3 availability in AUD or in at-risk populations. In line with a dimensional understanding of addiction, extrastriatal dopaminergic neuroadaptations have been suggested to be relevant from a pathobiological perspective. Methods: We investigated D2/3 receptor availability via 18F-fallypride positron emission tomography applying a region of interest (ROI) approach. We selected ROIs for the prefrontal cortex (PFC) and the anterior cingulate cortex (ACC). Our sample included 19 healthy controls (low risk [LR]), 19 individuals at high risk (HR) to develop addiction, and 20 recently detoxified AUD patients. Results: We found significantly higher D2/3 receptor availability of HR compared to AUD in the left and right rostral ACC (rACC), as well as in the left ventrolateral PFC (vlPFC). We did not observe a significant difference between AUD and LR. After corrections for multiple comparisons none of the ROIs reached significance throughout the group comparison. The D2/3 receptor availability in the left rACC was inversely correlated with symptom severity assessed with the Alcohol Dependency Scale. Discussion: To our knowledge, the present work is the first study investigating extrastriatal D2/3 receptor availabilities in individuals at HR and patients with AUD. The observation that D2/3 receptor availabilities are highest in HR might suggest that their pathobiology differs from subjects with AUD. Future studies are necessary to clarify the intraindividual course of this biomarker over different disease stages and its possible role as a risk or protective factor.

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“…Chronic alcohol intake is associated with lower dopamine receptor availability. In particular, reduced availability of dopamine D2 and D3 receptors (DRD2 and DRD3, respectively) in the striatum of patients with alcohol dependence compared to healthy controls (HCs) has been demonstrated by several positron emission tomography (PET) studies (Erritzoe et al, 2014;Gleich et al, 2020;Heinz et al, 2004Heinz et al, , 2005Hietala et al, 1994;Rominger et al, 2012;Volkow et al, 2002Volkow et al, , 2007 and described in recent reviews (Alexandre et al, 2019;Kamp et al, 2018). However, it is unclear whether these changes reflect neuroadaptations to excess acute striatal dopamine release during regular substance use or are the result of genetic predisposition for substance use disorder.…”

Section: Introductionmentioning

confidence: 99%

Association between DRD2/ANKK1 TaqIA allele status and striatal dopamine D2/3 receptor availability in alcohol use disorder

Spitta¹,

Fliedner²,

Gleich³

et al. 2021

Preprint

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The association between blunted dopaminergic neurotransmission and alcohol use disorder (AUD) is well-known. In particular, the impairment of postsynaptic dopamine 2 and 3 receptors (DRD2/3) in the ventral and dorsal striatum during the development and maintenance of alcohol addiction has been investigated in several positron emission tomography (PET) studies. However, it is unclear whether these changes are the result of adaptation or genetic predisposition. Here we investigated the association between DRD2/ankyrin repeat and kinase domain-containing 1 (ANKK1) TaqIA allele (rs1800497) status and striatal DRD2/3 availability measured by 18F-fallypride PET in 13 AUD patients and 17 sex-matched healthy controls. Age and smoking status were included as covariates. Contrary to our expectations, TaqIA allele status was not associated with striatal DRD2/3 availability in either group and there was no significant difference between groups, possibly due to the relatively small sample size (N=30). Nonetheless, this is the first in vivo study investigating the relationship between dopamine receptor availability and genetic factors in AUD. The pitfalls of assessing such relationships in a relatively small sample are discussed.

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Evaluation of the dopaminergic system with positron-emission tomography in alcohol abuse: A systematic review

Cited by 5 publications

References 42 publications

Dopamine and Alcohol: A Review of in vivo PET and SPECT Studies

Dopamine and Alcohol: A Review of in vivo PET and SPECT Studies

Extrastriatal Dopamine D2/3 Receptor Availability in Alcohol Use Disorder and Individuals at High Risk

Association between DRD2/ANKK1 TaqIA allele status and striatal dopamine D2/3 receptor availability in alcohol use disorder

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