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Abstract:We performed a systematic review to map the evidence and analyze the effect of whey protein supplementation in the elderly submitted to resistance training. Methods: A comprehensive search on Medline, LILACS, EMBASE and the Cochrane Library for relevant publications was conducted until August 2015. The terms used in the search were: "Resistance Training"; "Whey protein"; "elderly". Two authors independently assessed abstracts, texts in full and made critical appraisal. Results: A total of 632 studies were screened. Five studies were included composing a sample of 391 patients. The supplement whey protein was associated with higher total protein ingestion 9.40 (95% CI 4.03 to 14.78), and with an average change in plasma leucine concentration ranging from 406µmol/L to 490µmol/L compared with the control group. The supplementation was also associated with increased mixed muscle protein synthesis 1.26 (95% CI 0.46 to 2.07) compared to control group. Just one trial compared lean body mass in the group receiving whey protein supplementation and the control group (n=80) 0.07 (95% CI -0.37 to 0.51). Conclusion: We observed an increase in total protein intake, resulting in increased concentration of leucine and mixed muscle protein synthesis rate. No significant increase related to muscle mass or strength were observed.

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Background: Non-puerperal uterine inversions are rare. The objective of the study was to investigate the frequency, causes, clinical presentations, and management of published case reports of non-puerperal uterine inversion. Material and Methods: We searched MEDLINE, EMBASE, LILACS, the Cochrane Central Register of Controlled Trials, IBECS, BIOSIS, the Web of Science, SCOPUS, Conference Abstracts, and grey literature (Google scholar; the British Library) for papers published from January 1940 through March 2017. Results: We found a total of 170 case reports. The most common cause was leyomioma (57.2%) followed by sarcoma (13.5%). The definitive treatment of most cases was hysterectomy (86.8%). The median hemoglobin levels were seven, showing the severity of the condition by previous vaginal bleeding. All reported cases had a correct management demonstrated by the prognosis until hospital discharge. All patients were discharged, most of them without serious postoperative events. Cancer cases were referred for proper treatment. Only 2 cases of death were reported in 6 weeks and 3 months, respectively, both cases of cancer in advanced stages. Conclusion: Non-puerperal uterine inversion is rare. There have been 170 cases reports in the literature since 1940.

The data suggest that NGAL levels can be an important biomarker for the early detection of AKI in children.

Background The present study aimed to assess the association of vitamin D and vitamin B12 with cognitive impairment in elderly people. Methods The data were obtained from a cross‐sectional study that included individuals aged 80 years or older living in the urban and rural areas of the cities of Siderópolis and Treviso in the state of Santa Catarina, Brazil. In total, 165 elderly people were included in the analysis. The outcome of cognitive decline was assessed by the Mini‐Mental State Examination. Vitamin D and vitamin B12 levels were measured from blood samples. The socio‐demographic, anthropometric and health variables used in the analysis were collected from a questionnaire. Crude and adjusted analyses of the relationship between vitamins D and B12 and cognitive decline were performed using a Poisson regression model. Results The prevalence of cognitive decline was 35.2%. In the adjusted model, individuals who had vitamin D levels >19 ng mL−1 showed a lower prevalence of cognitive decline (prevalence ratio = 0.59; 95% confidence interval = 0.39–0.87). Those participants who had vitamin B12 levels of ≥496 pg mL−1 had a higher prevalence of cognitive decline (prevalence ratio = 1.90; 95% confidence interval = 1.08–3.36). Conclusions The present study showed that individuals aged ≥80 years who had vitamin D levels of ≤18 ng mL−1 had a higher prevalence of cognitive decline even after adjustment for potential confounders. In addition, the study demonstrated that vitamin B12 levels of ≥496 pg mL−1 in this population were also a risk factor for cognitive decline. A cross‐sectional analysis does not enable the inference of a cause–effect relationship and additional studies are needed to understand these relationships.