Evaluation of the Diagnostic Efficacy of Monocyte Parameters and MCP-1 to Distinguishing Active Tuberculosis from Latent Tuberculosis

Sun, Tingting; Wu, Bin; Wang, Jing; Yuan, Tao; Huang, Hengliu; Xu, Dongsheng; Shaoli,; Deng, Deng

doi:10.7754/clin.lab.2018.181115

Cited by 9 publications

(10 citation statements)

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“…MDW is also positively correlated with disease development and can predict disease progression. At the same time, there are also morphological changes in monocytes in some other disease processes (hepatitis B, 73 hepatitis C, 19 HIV infection, 18 Mycobacterium tuberculosis infection, 10,17,74 coronary heart diseases, and 75 rheumatoid arthritis 22 ); therefore, we can speculate that MDW may also have potential application value in these diseases. In addition, peripheral blood monocytes are an important source of macrophages, and MDW can also reflect some macrophage-related functions (pathogen infection, tumor immunity, immune monitoring, etc.…”

Section: Discussionmentioning

confidence: 97%

Diagnostic and Prognostic Value of Monocyte Distribution Width in Sepsis

Wu¹,

Li²,

Luo³

2022

JIR

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Monocyte distribution width (MDW) is a blood monocyte morphological parameter that can be easily detected by an automated hemocyte analyzer and can provide clinicians with important information about cell volume variability in peripheral blood monocyte populations. The United States’ Food and Drug Administration and Conformite Europeenne have both been cleared for their clinical application in the detection of sepsis and developing sepsis in adult patients in the emergency department (ED). Recently, MDW has been found to have an early diagnosis and predictive value for sepsis in neonates and COVID-19 patients. Here, we summarize the findings of the studies investigating the clinical application of MDW in sepsis. Under different stimuli, especially in infectious diseases, the activation of innate immunity is the host’s first defense mechanism, and the change in monocyte volume is considered an early indicator reflecting the state of activation of innate immunity. Pivotal study data from a large multicenter patient cohort showed that abnormal MDW at presentation increases the odds of sepsis, considering the combination of MDW and White Blood Cell Count (WBC) as part of a standard sepsis assessment protocol for ED, which may increase the sensitivity and specificity of sepsis diagnosis. Meanwhile, MDW shares a diagnostic performance comparable to that of conventional biomarkers (C-reactive protein and procalcitonin) in sepsis. In addition, some evidence suggests that increased MDW, both in adults and neonates, may be associated with unfavorable short- and long-term outcomes, which indicates its prognostic value in sepsis. Taken together, MDW is a parameter of increased morphological variability of monocytes in response to infection, and numerous studies have shown that MDW could be used as a valuable diagnostic and prognostic index in patients with sepsis or suspected sepsis.

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Section: Discussionmentioning

confidence: 97%

Diagnostic and Prognostic Value of Monocyte Distribution Width in Sepsis

Wu¹,

Li²,

Luo³

2022

JIR

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“…In addition, the increased levels of chemokines significantly correlate with bacterial burdens and disease severity, and its levels are reduced after successful anti-tuberculous chemotherapy (39). Moreover, monocyte morphometric parameters (mean monocyte volume and conductivity) and MCP-1 show significant sensitivity and specificity on order to distinguish active pulmonary TB from latent TB (47). Taken together, although the clinical relevance should be monitored in the large population of the patient groups depending on the clinical status, these data propose that there are several kinds of chemokines that can be useful as promising disease markers of TB, Low body mass index (LBMI) is known as one of the major risk factors of TB, and associated with systemic levels of tumor necrosis factor (TNF)-α and interleukin (IL)-2.…”

Section: Numerous Chemokines Can Be Useful Tb Markersmentioning

confidence: 99%

The Roles of Chemokines in Immune Response to Mycobacterial Infection

Paik

Yang

Suh

et al. 2020

jbv

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Tuberculosis (TB), a global and deadly infectious disease caused by Mycobacterium tuberculosis (Mtb), is manifested with host immune reaction. The balanced regulation between protective immune and pathologic inflammatory responses is critical to control progression to TB. Chemokines are a large family of cytokines that play an essential role for chemotaxis of immune and inflammatory cells to the sites of infection. Numerous chemokines including CXCL10 were reported as potential biomarkers of various stages of TB infection. In addition, several chemokines and their receptors play as key players to coordinate host immune defense as innate effectors and mediators of adaptive immune responses. Accumulating evidence suggests that some chemokines, if uncontrolled, are associated with host pathological inflammation during infection. In this review, we will discuss recent advances in understanding which chemokines have potentials as diagnostic markers. In addition, we focus the roles and mechanisms by which chemokines and their receptors are involved in both host immune protection and pathology during TB infection. The controlled activation of chemokine system will determine the coordinated biological outcomes of innate immune responses during pathogenic infection.

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“…It is, therefore, necessary to distinguish disease states and to conduct rapid examination. Thus, researchers conducted studies to distinguish LTBI from active TB by using cytokines specific to the MTB antigens, by using differentially expressed genes with subsequent validation via reverse transcription polymerase chain reaction (RT-PCR), and by using monocyte chemoattractant protein-1 (MCP-1) [ 8 , 9 , 10 ].…”

Section: Introductionmentioning

confidence: 99%

High Procalcitonin, C-Reactive Protein, and α-1 Acid Glycoprotein Levels in Whole Blood Samples Could Help Rapid Discrimination of Active Tuberculosis from Latent Tuberculosis Infection and Healthy Individuals

Kang

Park

et al. 2022

Microorganisms

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Tuberculosis (TB) management is important for prompt discrimination of latent TB infection (LTBI) from active TB and proper treatment. Whole blood Interferon-gamma (IFN-γ) release assay (IGRA) is used to diagnose LTBI based on the secretion of IFN-γ by T-cells in the whole blood by using a specific antigen of Mycobacterium tuberculosis. However, the ability of IGRA to distinguish active TB from LTBI is considerably limited. Distinguishing active TB from LTBI is necessary to identify indicators that can be used to effectively manage TB and develop diagnostic methods. In the present study, we used a Luminex multiplex bead array (a bead-based antibody–antigen sandwich method). The whole blood level of acute phase proteins (APPs), such as endoglin (ENG), procalcitonin (PCT), C-reactive protein (CRP), and α1-acid glycoprotein (AGP), in active TB, LTBI, and healthy individuals were analyzed and quantified. The APP test results for the serum and whole blood samples showed that the levels of PCT, CRP, and AGP were significantly increased (p < 0.0500; area under curve = 0.955) in active TB. The level of these markers in the whole blood of active TB, LTBI, and healthy individuals could provide data for effective diagnosis and treatment of TB.

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Evaluation of the Diagnostic Efficacy of Monocyte Parameters and MCP-1 to Distinguishing Active Tuberculosis from Latent Tuberculosis

Cited by 9 publications

References 0 publications

Diagnostic and Prognostic Value of Monocyte Distribution Width in Sepsis

Diagnostic and Prognostic Value of Monocyte Distribution Width in Sepsis

The Roles of Chemokines in Immune Response to Mycobacterial Infection

High Procalcitonin, C-Reactive Protein, and α-1 Acid Glycoprotein Levels in Whole Blood Samples Could Help Rapid Discrimination of Active Tuberculosis from Latent Tuberculosis Infection and Healthy Individuals

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