Evaluation of the Debye temperature for iron cores in human liver ferritin and its pharmaceutical analogue, Ferrum Lek, using Mössbauer spectroscopy

Abstract

An iron-polymaltose complex Ferrum Lek used as antianemic drug and considered as a ferritin analogue and human liver ferritin were investigated in the temperature range of 295-90 K by means of 57 Fe Mössbauer spectroscopy with a high velocity resolution (in 4096 channels). The Debye temperatures Ө D =50224 K for Ferrum Lek and Ө D =46116 K for human liver ferritin were determined from the temperature dependence of the center shift obtained using two different fitting procedures.

Determination of Debye temperatures and Lamb–Mössbauer factors for LnFeO3orthoferrite perovskites (Ln = La, Nd, Sm, Eu, Gd)

“…This process is not to fit the data presented against a theoretical line from Figure 7, and these lines are principally to guide the approximation procedure. Approximating the Debye temperature in this manner has been shown to reliably produce accurate values by Dubiel and colleagues previously [51,58], and here, summarised in [58] 435 (10) 437 (7) 0.80 (2) Kim CoFe 2 O 4 Site A [59] 738 (10) 734 (5) 0.92 (2) Figure 7. Theoretical trend lines of Centre Shifts for given θ D (solid lines) and experimental data for LaFeO 3 (circles)with intrinsic Isomer Shift = 0.61 mm s -1 .…”

“…The temperature dependence of Centre Shift (CS) in Mössbauer spectra can be predicted by the Debye model for a given material, allowing variable temperature Mössbauer spectroscopy studies to approximate the Debye temperature [48], and by extension, the recoil-free fraction [49][50][51]. The recoil-free fraction, f factor, or Lamb-Mössbauer factor, is the temperature-dependent ratio of the recoilless γ absorption of a material, therefore the greater the f factor, the greater the Mössbauer spectral area by comparison with a material with a smaller f factor.…”

Mössbauer spectroscopy of human liver ferritin and its analogue, Ferrum Lek, in the temperature range of 295-90 K: Comparison within the homogeneous iron core model

“…At the same temperatures, some changes in the temperature dependence of quadrupole splitting was also observed. There were no unusual temperature dependence found for the isomer shift, the Debye temperature was evaluated as 461 ± 16 K for human liver ferritin and 502 ± 24 K for Ferrum Lek (for details, see [23]). The unusual temperature dependences of the relative areas for the Mössbauer spectra of human liver ferritin and Ferrum Lek demonstrated the possible minimum of the 57 Fe mean square displacement at 115 K for human liver ferritin and at 105 K for Ferrum Lek in the temperature range of 295-90 K. The observed unusual temperature dependences of the Mössbauer parameters were considered as a result of possible low-temperature phase transition in the iron cores of human liver ferritin and its analogue, Ferrum Lek.…”

Enhanced oral bioavailability and tissue distribution of ferric citrate through liposomal encapsulation

“…Recently, different iron supplements have been researched and developed to mitigate the situation of iron deficiency. These iron supplements included Fe (II) sulfate agent (Ferrari, Nicolini, Manca, Rossi, & Anselmi, 2012), ferric citrate (FAC) formulation (Bates, Billups, & Saltman, 1967), ferrous-based combination product (Ferall) (Liu, Lin, Chang, Yang, & Chen, 2004), heme-iron fortificant (Cao, Thomas, Insogna, & O'Brien, 2014), polysaccharide iron complex (Dubiel, Cieslak, Alenkina, Oshtrakh, & Semionkin, 2014;Wang et al, 2008;Zhang, Liu, Su, Lui, & Li, 2009), iron amino acid chelate (Ding et al, 2011;Mimura, Breganó, Dichi, Gregório, & Dichi, 2008), ferric citrate-loaded liposomes (FAC-LIP) (Yuan et al, 2013) and amino acid chelated iron liposomes (Ding et al, 2011). Among these iron supplements, iron liposomes have gained considerable attention for its role in the treatment of AI.…”