Evaluation of the cytotoxic activity of polyethers isolated from Laurencia

Fernández, JoséJ.; Souto, Marı́a L.; Norte, Manuel

doi:10.1016/s0968-0896(98)80004-7

Cited by 35 publications

(34 citation statements)

References 11 publications

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“…Moreover, the high content of phytosterols in the tested algae extracts plays an important role in their antitumor effect, since it has been reported that those phytosterols could stimulate apoptosis of cancer cells in culture (Awad et al, 2000). Regarding Laurencia obtusa, it has been reported that this macroalgae contains triterpenes with squalene carbon skeleton which have antitumor activity (Fernandez et al, 1998). Interestingly, the extract of the green alga Caulerpa prolifera (E2) was more effective in inhibiting AFB 1 -induced hepatic toxicity than the extract of the red alga Laurencia obtusa (E1).…”

Section: Discussionmentioning

confidence: 99%

Prevention of aflatoxin B1-initiated hepatotoxicity in rat by marine algae extracts

2006

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Chemoprevention by extracts of Laurencia obtusa (E1) and Caulerpa prolifera (E2) collected from the Egyptian coast of the Red Sea against aflatoxin B(1) (AFB(1))-initiated hepatotoxicity in female Sprague-Dawley rats has been studied. Animals were fed aflatoxin-contaminated diet (3 mg kg(-1) diet) for 6 days then treated orally with pure aflatoxin B(1) (AFB(1)) (200 microg kg(-1) b.w.) for 4 days either in combination with or before E1 or E2 administration (50 mg kg(-1) b.w.). AFB(1) resulted in a signicant increase in serum alpha fetoprotein, carcinoembryonic antigen, tumor necrosis factor alpha, nitric oxide, interleukin-1alpha, procollagen III and lipid peroxidation level in the liver. It caused a signicant decrease in food intake, body weight, serum leptin, the activities of glutathione peroxidase, superoxide dismutase and DNA and RNA concentrations in the liver. Cotreatment with AFB(1) and E1 or E2 resulted in an obvious improvement in all tested parameters. Noteworthy, E2 was more effective than E1 in the protection against AFB(1)-induced hepatotoxicity.

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Section: Discussionmentioning

confidence: 99%

Prevention of aflatoxin B1-initiated hepatotoxicity in rat by marine algae extracts

2006

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“…The prominent biological activity of marine terpenes is evident in their ecological role in the marine environment and makes them interesting as potential drugs. Many of these natural products are pharmacologically active and marine algae, especially those from tropical and subtropical seas, are able to produce a wide range of compounds, many of which exhibit at least some degree of bioactivity (Fernández et al, 1998(Fernández et al, , 2005da Gama et al, 2002;Cassano et al, 2008;Lhullier et al, 2009;Machado et al, 2011;Santos et al, 2010). In fact, the marine environment represents a treasure trove of useful products awaiting discovery for the treatment of infectious and parasitic diseases (Vairappan et al, 2004;Morales et al, 2006), cancer (Mohammed et al, 2004;Stein et al, 2011), cognitive diseases, inflammatory processes, and viral infections (Sakemi et al, 1986).…”

Section: Introductionmentioning

confidence: 99%

Overview of the taxonomy and of the major secondary metabolites and their biological activities related to human health of the Laurencia complex (Ceramiales, Rhodophyta) from Brazil

Fujii¹,

Cassano²,

Stein³

et al. 2011

Rev. bras. farmacogn.

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Abstract:In Brazil, the Laurencia complex is represented by twenty taxa: Laurencia s.s. with twelve species, Palisada with four species (including Chondrophycus furcatus now that the proposal of its transference to Palisada is in process), and Osmundea and Yuzurua with two species each. The majority of the Brazilian species of the Laurencia complex have been phylogenetically analyzed by 54 rbcL sequences, including five other Rhodomelacean species as outgroups. The analysis showed that the Laurencia complex is monophyletic with high posterior probability value. The complex was separated into five clades, corresponding to the genera: Chondrophycus, Laurencia, Osmundea, Palisada, and Yuzurua. A bibliographical survey of the terpenoids produced by Brazilian species showed that only six species of Laurencia and five of Palisada (including C. furcatcus) have been submitted to chemical analysis with 48 terpenoids (47 sesquiterpenes and one triterpene) isolated. No diterpenes were found. Of the total, 23 sesquiterpenes belong to the bisabolane class and eighteen to the chamigrene type, whose biochemical precursor is bisabolane, two are derived from lauranes and four are triquinols. Despite the considerable number of known terpenes and their ecological and pharmacological importance, few experimental biological studies have been performed. In this review, only bioactivities related to human health were considered.

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“…Algal samples of L. viridis collected from Canary Islands were proven to be the largest reservoir not only for the halogenated triterpene polyethers but also for the nonhalogenated ones (Wang et al 2013;Fernández et al 2000). From this species, six nonhalogenated triterpene polyethers (114-119) with a 2,7-dioxabicyclo[4,4,0]decane system were identified, and 114, 115, and 118 displayed remarkable cytotoxicity against several tumor cell lines, including P388, A549, HT29, MEL28, Jurkat, MM144, Hela, and CADO-ES1 (Norte et al 1997;Fernández et al 1998;Pacheco et al 2011;Souto et al 2002;Manríquez et al 2001). Biogenetically, the intermediates with 1,2-epoxy groups, rather than bromonium ions, might play a key role in the formation of nonhalogenated triterpene polyethers (Fernández et al 2000).…”

Section: Nonhalogenated Triterpenesmentioning

confidence: 99%

Nonhalogenated organic molecules from Laurencia algae

Wang

2013

Phytochem Rev

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The marine red algae of the genus Laurencia have produced more 700 secondary metabolites and exhibited high molecular diversity and intriguing bioactivity. Since the halogenated structures have been comprehensively reviewed previously, this review, covering up to the end of 2012, mainly focuses on the source, structure elucidation, and bioactivity of nonhalogenated organic molecules from Laurencia spp. as well as the relationship between nonhalogenated and halogenated products. Overall, 173 new or new naturally occurring compounds with 58 skeletons, mainly including sesquiterpenes, diterpenes, triterpenes, and C 15 -acetogenins, are described.

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Evaluation of the cytotoxic activity of polyethers isolated from Laurencia

Cited by 35 publications

References 11 publications

Prevention of aflatoxin B1-initiated hepatotoxicity in rat by marine algae extracts

Prevention of aflatoxin B1-initiated hepatotoxicity in rat by marine algae extracts

Overview of the taxonomy and of the major secondary metabolites and their biological activities related to human health of the Laurencia complex (Ceramiales, Rhodophyta) from Brazil

Nonhalogenated organic molecules from Laurencia algae

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