1998
DOI: 10.1016/s0968-0896(98)80004-7
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Evaluation of the cytotoxic activity of polyethers isolated from Laurencia

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Cited by 35 publications
(34 citation statements)
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“…Moreover, the high content of phytosterols in the tested algae extracts plays an important role in their antitumor effect, since it has been reported that those phytosterols could stimulate apoptosis of cancer cells in culture (Awad et al, 2000). Regarding Laurencia obtusa, it has been reported that this macroalgae contains triterpenes with squalene carbon skeleton which have antitumor activity (Fernandez et al, 1998). Interestingly, the extract of the green alga Caulerpa prolifera (E2) was more effective in inhibiting AFB 1 -induced hepatic toxicity than the extract of the red alga Laurencia obtusa (E1).…”
Section: Discussionmentioning
confidence: 99%
“…Moreover, the high content of phytosterols in the tested algae extracts plays an important role in their antitumor effect, since it has been reported that those phytosterols could stimulate apoptosis of cancer cells in culture (Awad et al, 2000). Regarding Laurencia obtusa, it has been reported that this macroalgae contains triterpenes with squalene carbon skeleton which have antitumor activity (Fernandez et al, 1998). Interestingly, the extract of the green alga Caulerpa prolifera (E2) was more effective in inhibiting AFB 1 -induced hepatic toxicity than the extract of the red alga Laurencia obtusa (E1).…”
Section: Discussionmentioning
confidence: 99%
“…The prominent biological activity of marine terpenes is evident in their ecological role in the marine environment and makes them interesting as potential drugs. Many of these natural products are pharmacologically active and marine algae, especially those from tropical and subtropical seas, are able to produce a wide range of compounds, many of which exhibit at least some degree of bioactivity (Fernández et al, 1998(Fernández et al, , 2005da Gama et al, 2002;Cassano et al, 2008;Lhullier et al, 2009;Machado et al, 2011;Santos et al, 2010). In fact, the marine environment represents a treasure trove of useful products awaiting discovery for the treatment of infectious and parasitic diseases (Vairappan et al, 2004;Morales et al, 2006), cancer (Mohammed et al, 2004;Stein et al, 2011), cognitive diseases, inflammatory processes, and viral infections (Sakemi et al, 1986).…”
Section: Introductionmentioning
confidence: 99%
“…Algal samples of L. viridis collected from Canary Islands were proven to be the largest reservoir not only for the halogenated triterpene polyethers but also for the nonhalogenated ones (Wang et al 2013;Fernández et al 2000). From this species, six nonhalogenated triterpene polyethers (114-119) with a 2,7-dioxabicyclo[4,4,0]decane system were identified, and 114, 115, and 118 displayed remarkable cytotoxicity against several tumor cell lines, including P388, A549, HT29, MEL28, Jurkat, MM144, Hela, and CADO-ES1 (Norte et al 1997;Fernández et al 1998;Pacheco et al 2011;Souto et al 2002;Manríquez et al 2001). Biogenetically, the intermediates with 1,2-epoxy groups, rather than bromonium ions, might play a key role in the formation of nonhalogenated triterpene polyethers (Fernández et al 2000).…”
Section: Nonhalogenated Triterpenesmentioning
confidence: 99%