Evaluation of the Correlation between Socioeconomic Factors and Pediatric Cleft Lip and Palate

Habibi, Mehdi; Vahdat, Shaghayegh

doi:10.30699/mmlj17.4.2.40

Cited by 2 publications

(2 citation statements)

References 48 publications

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“…Besides data confirming the role of genetics in the aetiology of OFCs, scientific studies and epidemiological data show that environmental risk factors (e.g., smoking, alcohol and malnutrition in pregnancy, viral infections, teratogenic pharmacological agents, folate deficiency, weight) intervene significantly in the complex embryological development determining malformation [ 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 ].…”

Section: Introductionmentioning

confidence: 99%

Modifiable Risk Factors of Non-Syndromic Orofacial Clefts: A Systematic Review

Inchingolo

Fatone²,

Malcangi

et al. 2022

Children

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OFCs (orofacial clefts) are among the most frequent congenital defects, but their etiology has yet to be clarified. OFCs affect different structures and functions with social, psychological and economic implications in children and their families. Identifying modifiable risk factors is mandatory to prevent the occurrence of non-syndromic OFCs (NSOFCs). PubMed, Cochrane Library, Scopus and Web of Science were searched from 1 January 2012 to 25 May 2022 and a total of 7668 publications were identified. Studies focusing on the risk factors of NSOFCs were selected, leading to 62 case-control and randomized clinical trials. Risk factors were categorized into non-modifiable and modifiable. The first group includes genetic polymorphisms, gender of the newborn, ethnicity, and familiarity. Within the second group, risk factors that can only be modified before conception (consanguinity, parental age at conception, socio-economical and educational level, area of residency and climate), and risk factors modifiable before and after conception (weight, nutritional state, acute and chronic diseases, psychophysical stress, licit and illicit drugs, alcohol, smoke, pollutants and contaminants) have been distinguished. This study provides a wide overview of the risk factors of NSOFCs, focusing on modifiable ones, to suggest new perspectives in education, prevention, medical interventions and clinical research.

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Section: Introductionmentioning

confidence: 99%

Modifiable Risk Factors of Non-Syndromic Orofacial Clefts: A Systematic Review

Inchingolo

Fatone²,

Malcangi

et al. 2022

Children

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“…Scientific and epidemiological research highlights the significant impact of environmental risk factors, including smoking, alcohol consumption, malnutrition during pregnancy, viral infections, teratogenic drugs, folate deficiency, and body mass, on the development of these congenital anomalies. These environmental influences, alongside genetic predispositions, contribute to the complex embryonic development leading to cleft formation [12][13][14]. Children with cleft lip and palate face challenges in speech, feeding, and hearing, as well as cosmetic and psychological issues, necessitating comprehensive and long-term multidisciplinary care.…”

Section: Introductionmentioning

confidence: 99%

Characteristics of Factors Influencing the Occurrence of Cleft Lip and/or Palate: A Case Analysis and Literature Review

Kulesa-Mrowiecka,

Lipowicz,

Marszałek-Kruk

et al. 2024

Children

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Introduction: Cleft lip with or without cleft palate (CL/P) stands as the most common congenital facial anomaly, stemming from multifactorial causes. Objective: Our study aimed to ascertain the prevalence and characteristics of cleft palates, identify associated risk factors to inform prevention and prenatal detection for early intervention, and assess postoperative rehabilitation protocols for cleft palates. Design: This study employs a retrospective descriptive and clinical approach. Patients: The study includes 103 children with cleft palates treated at the Department of Head and Neck Surgery Clinic for Children and Young Adults, Department of Clinical Pediatrics, University of Warmia and Mazury. Methods: We conducted a thorough evaluation of records, considering variables such as sex, cleft type, maternal occupation, parental education, and family history of clefts. Data analysis was carried out using R software version GPL-3 and ordinal logistic regression analyses. Results: Notably, children born to mothers who experienced significant stress during pregnancy exhibited a 9.4-fold increase in the odds of having bilateral cleft palates. Conversely, no substantial evidence was found to support the influence of the child’s sex, birth order, body mass, maternal exposure to workplace toxins, infections, or drug toxicity on the dependent variable. Conclusions: Our findings suggest that children with parents who have a history of clefts and those with less educated mothers are more likely to develop bilateral cleft palates. Additionally, children born to mothers experiencing stress during pregnancy face an increased risk of bilateral cleft palates. It is important to note that there is a paucity of literature on rehabilitation following various cleft palate surgical techniques in children.

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Evaluation of the Correlation between Socioeconomic Factors and Pediatric Cleft Lip and Palate

Cited by 2 publications

References 48 publications

Modifiable Risk Factors of Non-Syndromic Orofacial Clefts: A Systematic Review

Modifiable Risk Factors of Non-Syndromic Orofacial Clefts: A Systematic Review

Characteristics of Factors Influencing the Occurrence of Cleft Lip and/or Palate: A Case Analysis and Literature Review

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